anti-Protein Kinase N1 (PKN1) Antibodies

The protein encoded by PKN1 belongs to the protein kinase C superfamily. Additionally we are shipping PKN1 Kits (27) and PKN1 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PKN1 84432 P58294
PKN1 320795 P70268
PKN1 29355 Q63433
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Top anti-PKN1 Antibodies at

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Dog Mouse Un-conjugated IF, IP, WB Western blot analysis of PRK1 on Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of PRK1. MCF7 cells (ATCC HTB-22) 150 μg Log in to see 6 to 8 Days
Dog Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of PRK1 on Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of PRK1. MCF7 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
Cow Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of PKN1 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of PKN1 expression in HEK293T (A), HepG2 (B), SP2/0 (C), NIH3T3 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Dog Rabbit Un-conjugated WB   200 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cells, using PKN1 antibody. Immunohistochemistry of paraffin-embedded mouse brain using PKN1 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB   100 μL Log in to see 8 to 11 Days
Dog Rabbit Un-conjugated IHC (fro), IHC (p), IP, WB   50 μL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated WB   100 μL Log in to see 7 to 9 Days

PKN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
Rat (Rattus)

Top referenced anti-PKN1 Antibodies

  1. Dog (Canine) Monoclonal PKN1 Primary Antibody for IF, IP - ABIN968110 : Flynn, Mellor, Casamassima, Parker: Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 Pubmed References

  2. Dog (Canine) Monoclonal PKN1 Primary Antibody for IF, IP - ABIN968111 : Hughes, Larijani, Parker: Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 Pubmed References

More Antibodies against PKN1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Protein Kinase N1 (PKN1) interaction partners

  1. polarity-induced spatiotemporal control of Rok (show ROCK1 Antibodies) and Pkn is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.

  2. The delorean phenotype, with its associated defects in wing morphology, provides evidence of a role for PKN in adult morphogenetic processes.

  3. Drosophila protein kinase N is a negative regulator of actin-myosin activity during oogenesis.

  4. identified a requirement for Pkn in wing morphogenesis, thereby revealing the first postembryonic function for Pkn

Human Protein Kinase N1 (PKN1) interaction partners

  1. PKN1 activity was up-regulated by the active RhoA (show RHOA Antibodies) mutant (G14V) and suppressed by RhoA (show RHOA Antibodies) T19N. PKN1 siRNA interrupted the ability of RhoA (show RHOA Antibodies) to promote ESC proliferation and DNA synthesis. The effect of RhoA (show RHOA Antibodies) on ESC proliferation is mediated by activation of the PKN1-cyclin D1 (show CCND1 Antibodies) pathway in vitro.

  2. These findings demonstrate a novel function of primary cilia in controlling EG-VEGF (show Prok1 Antibodies)-regulated trophoblast invasion and reveal the underlying molecular mechanism.

  3. miR (show MLXIP Antibodies)-346 and miR (show MLXIP Antibodies)-582-3p regulate EG-VEGF (show Prok1 Antibodies)-induced trophoblast invasion through repressing MMP 2 (show MMP2 Antibodies) and MMP 9 (show MMP9 Antibodies), and may become novel diagnostic biomarkers or therapeutic targets for EG-VEGF (show Prok1 Antibodies)-related obstetric disorders. (c) 2016 BioFactors, 43(2):210-219, 2017.

  4. Each follicular fluid (FF) was individually aspirated and FF/serum EG-VEGF (show Prok1 Antibodies), inhibin-a (show INHA Antibodies), and FF IGF-1 (show IGF1 Antibodies) levels were evaluated. The pregnant group was characterized by increased numbers of WVFs (p = 0.044), a WVE (p = 0.022), and increased levels of FF IGF-1 (show IGF1 Antibodies) (p = 0.001) and serum EG-VEGF (show Prok1 Antibodies) (p = 0.03).

  5. Results show the biological effects of PROK1 (show Prok1 Antibodies)-V67I on cell functions are similar to those of wild type, and the common variant of V67I may act as a modifier in the PROK1 (show Prok1 Antibodies)-PROKR system through down-regulation of PROK1 (show Prok1 Antibodies) expression.

  6. Data suggest that prokineticins (PROK1 (show Prok1 Antibodies) and PROK2 (show PROK2 Antibodies)) and prokineticin receptors (PROKR1 (show PROKR1 Antibodies) and PROKR2 (show PROKR2 Antibodies)) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]

  7. EG-VEGF (show Prok1 Antibodies) and its receptor PKR1 (show PROKR1 Antibodies) might play a role in the pathogenesis of adrenocortical tumors and could serve as prognostic markers for this rare malignant disease.

  8. The prognosis was poorer in colorectal cancers that expressed both PROK1 and VEGF relative to the cases that expressed only 1 protein, and the expression of both proteins was found to be an independent prognostic factor.

  9. TXA2 (show TBXA2R Antibodies)-mediated neoplastic responses in prostate adenocarcinoma PC-3 (show PCSK1 Antibodies) cells occur through a PRK1/PRK2 (show PKN2 Antibodies)-dependent mechanism.

  10. PROK1 (show Prok1 Antibodies) levels in follicular fluid and fertilization culture media could constitute new predictive noninvasive markers of successful embryo implantation in conventional in vitro fertilization-embryo transfer

Mouse (Murine) Protein Kinase N1 (PKN1) interaction partners

  1. Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 and PRK2 (show PKN2 Antibodies) to negatively regulate pyrin (show MEFV Antibodies) by phosphorylation.

  2. Protein kinase N1, a cell inhibitor of Akt (show AKT1 Antibodies) kinase, has a central role in quality control of germinal center formation

  3. PKN is activated by ischemia/reperfusion and inhibits apoptosis of cardiac myocytes, thereby protecting the heart from I/R injury.

  4. Leishmania mexicana infectivity is associated with differential expression of protein kinase C (show PKC Antibodies)-like triggered during a cell-cell contact

  5. Pkn1 is involved in ganglioside signals that regulate TNF-alpha (show TNF Antibodies) signaling and synthesis.

PKN1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with PKN1

  • Protein kinase related to protein kinase N (Pkn) antibody
  • protein kinase N1 (PKN1) antibody
  • zgc:162290 (zgc:162290) antibody
  • protein kinase N1 (pkn1) antibody
  • prokineticin 1 (PROK1) antibody
  • protein kinase N1 (Pkn1) antibody
  • 3-2 antibody
  • CG2049 antibody
  • CG2055 antibody
  • CT6637 antibody
  • CT6660 antibody
  • DBK antibody
  • Dmel\\CG2049 antibody
  • dPKN antibody
  • EGVEGF antibody
  • F730027O18Rik antibody
  • l(2)06736 antibody
  • l(2)45Ca antibody
  • PAK-1 antibody
  • PAK1 antibody
  • PK1 antibody
  • Pk45C antibody
  • Pk?3 antibody
  • Pkn antibody
  • PKN-ALPHA antibody
  • PKN1 antibody
  • PRK1 antibody
  • PRK2 antibody
  • Prkcl1 antibody
  • Stk3 antibody
  • v(2)rG232 antibody

Protein level used designations for PKN1

CG2049-PB , CG2049-PC , CG2049-PD , CG2049-PE , CG2049-PF , CG2049-PG , CG2049-PH , CG2049-PI , CG2049-PJ , CG2049-PK , CG2049-PL , CG2049-PM , Pkn-PB , Pkn-PC , Pkn-PD , Pkn-PE , Pkn-PF , Pkn-PG , Pkn-PH , Pkn-PI , Pkn-PJ , Pkn-PK , Pkn-PL , Pkn-PM , protein kinase N , protein kinase c related , protein kinase related to protein kinase N , protein kinase-like 45C , protein kinase N1 , serine/threonine-protein kinase N1-like , EG-VEGF , black mamba toxin-related protein , endocrine-gland-derived vascular endothelial growth factor , mambakine , prokineticin-1 , protease-activated kinase 1 , protein kinase C-like 1 , protein kinase C-like PKN , protein kinase C-related kinase 1 , protein kinase PKN-alpha , protein-kinase C-related kinase 1 , serine-threonine kinase N , serine-threonine protein kinase N , serine/threonine protein kinase N , serine/threonine-protein kinase N1 , serine/threonine kinase 3 , protein kinase PKN

35950 Drosophila melanogaster
455785 Pan troglodytes
100007897 Danio rerio
100379847 Xenopus (Silurana) tropicalis
100401855 Callithrix jacchus
84432 Homo sapiens
5585 Homo sapiens
320795 Mus musculus
29355 Rattus norvegicus
100713234 Cavia porcellus
509080 Bos taurus
101118101 Ovis aries
484903 Canis lupus familiaris
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