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PPP1R1B encodes a bifunctional signal transduction molecule. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Kits (11) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Proteins (8) and many more products for this protein.
Showing 10 out of 217 products:
Human Polyclonal PPP1R1B Primary Antibody for WB - ABIN152574
Han, Han, Tiwari, Wen, Zheng: Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. in The Journal of cell biology 2007
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Mouse (Murine) Monoclonal PPP1R1B Primary Antibody for IF, WB - ABIN968572
Bibb, Snyder, Nishi, Yan, Meijer, Fienberg, Tsai, Kwon, Girault, Czernik, Huganir, Hemmings, Nairn, Greengard: Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. in Nature 2000
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Mouse (Murine) Polyclonal PPP1R1B Primary Antibody for IHC, WB - ABIN4304299
Yabuki, Ohizumi, Yokosuka, Mimaki, Fukunaga: Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice. in Neuroscience 2014
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Human Polyclonal PPP1R1B Primary Antibody for IF - ABIN401600
Alves, Régulier, Nascimento-Ferreira, Hassig, Dufour, Koeppen, Carvalho, Simões, de Lima, Brouillet, Gould, Déglon, de Almeida: Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. in Human molecular genetics 2008
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Human Monoclonal PPP1R1B Primary Antibody for FACS, ELISA - ABIN1724929
Hamel, Bouchard, Ferrario, Hassan, Aguilar-Mahecha, Buchanan, Quenneville, Miller, Basik: Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers. in Breast cancer research and treatment 2010
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Human Monoclonal PPP1R1B Primary Antibody for ELISA, WB - ABIN1724915
Kunii, Ikemoto, Wada, Yang, Kusakabe, Suzuki, Niwa: Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study. in Medical molecular morphology 2011
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Human Polyclonal PPP1R1B Primary Antibody for IHC (p), IHC - ABIN152638
Shioda, Han, Moriguchi, Fukunaga: Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia. in Journal of neurochemistry 2007
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DARPP-32 and I-1 were most frequently identified in dendritic shafts, unlike the D1R (show DRD1 Antibodies) and PP1 (show PPYR1 Antibodies) isoforms. Moreover, DARPP-32 and I-1 were only present in approximately 4% and 8% of area 9 pyramidal cell spines, respectively.
Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum.
In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth.
This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.
DARPP-32 is mainly cleaved at Thr (show TRH Antibodies)(153) by calpain and this cleavage of DARPP-32 reduces CREB (show CREB1 Antibodies) phosphorylation via loss of its inhibitory function on PP1 (show PPA1 Antibodies); results suggest a novel mechanism of DARPP-32-CREB (show CREB1 Antibodies) signalling dysregulation in Alzheimer's disease
No significant differences in mRNA expression levels of DRD2 (show DRD2 Antibodies) and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder.
Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity
Findings show that PPP1R1B-STARD3 (show STARD3 Antibodies) fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling.
Results suggest that variation in PPP1R1B affects the abundance of the splice variant t-DARPP-32 mRNA and may reflect potential molecular mechanisms implicated in schizophrenia and affective disorders
The immunostaining was more decreased for DARPP-32 than for the morphological changes of striatal neurons in multiple system atrophy.
This study showed that variations in genotypes relevant for DARPP-32 functions are associated more with aging-related impairments in the explicit than the implicit component of sequence learning.
the results suggest that by inducing dephosphorylation of DARPP-32 at Ser (show SIGLEC1 Antibodies)-97 and altering its cytonuclear distribution, glutamate (show GRIN1 Antibodies) may counteract dopamine/D1 receptor (show DRD1 Antibodies)/PKA signaling at multiple cellular levels.
Darpp32 interaction with beta-adducin (show ADD2 Antibodies) may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.
Results show that Darpp-32 was expressed in normal mouse mammary tissue and in some breast tumors, whereas t-Darpp was found exclusively in mammry tumors.
analysis of cAMP-activated DARPP-32 signalling to the nucleus
Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 (show TSC1 Antibodies) with a Darpp32-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.
Cannabinoid-stimulated G-protein activity did not differ between DARPP-32 KO and WT mice treated with vehicle or repeated THC.
In this work, the dissected postsynaptic topology of the DARPP-32 phosphoprotein provides strong evidence for a compartmentalized and confined distribution in dendritic spines.
Adenosine AA receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.
Data suggest that histone deacetylase (show HDAC1 Antibodies) inhibitors inhibit the induction of NGF1A-binding protein (show NAB1 Antibodies) Nab2 (show NAB2 Antibodies) by brain derived neurotrophic factor (BDNF (show BDNF Antibodies)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (show ARPP21 Antibodies), 32 kDa (DARPP-32).
Areas of brain and spinal cord that are densely innervated by tyrosine hydroxylase (show TH Antibodies)-immunoreactive fibers display a remarkable immunoreactivity for DARPP-32/ppp1r1b in cell bodies and neuropil.
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
, neuronal phosphoprotein DARPP-32
, protein phosphatase 1 regulatory subunit 1B
, protein phosphatase 1, regulatory (inhibitor) subunit 1B
, dopamine- and cAMP-regulated neuronal phosphoprotein
, dopamine- and cAMP-regulated phosphoprotein DARPP-32
, dopamine and cAMP-regulated neuronal phosphoprotein 32
, dopamine and cAMP regulated