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PPP4R1 encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). Additionally we are shipping Protein Phosphatase 4, Regulatory Subunit 1 Antibodies (21) and many more products for this protein.
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PP4R1 could mediate the dephosphorylation of TRAF2 (show TRAF2 Proteins) Ser11.
PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK (show CHUK Proteins) activity, T cell hyperactivation, and aberrant NF-kappaB (show NFKB1 Proteins) signaling in NF-kappaB (show NFKB1 Proteins)-addicted T cell lymphomas
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
protein phosphatase 4, regulatory subunit 1
, serine/threonine phosphatase 4
, serine/threonine-protein phosphatase 4 regulatory subunit 1