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Protein Phosphatase 6, Catalytic Subunit Proteins (PPP6C)

PPP6C encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Additionally we are shipping Protein Phosphatase 6, Catalytic Subunit Antibodies (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPP6C 5537 O00743
PPP6C 67857 Q9CQR6
Rat PPP6C PPP6C 171121 Q64620
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Top Protein Phosphatase 6, Catalytic Subunit Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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PPP6C Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Protein Phosphatase 6, Catalytic Subunit (PPP6C) Interaction Partners

Human Protein Phosphatase 6, Catalytic Subunit (PPP6C) interaction partners

  1. findings suggest that BRCA1 is a novel modulator of PP6 signalling via its interaction with ANKRD28.

  2. Data show 408 phosphopeptides on 272 proteins that increased and 298 phosphopeptides on 220 proteins that decreased in phosphorylation upon catalytic subunit of rotein phosphatase 6 (PP6c) depletion in mitotic cells.

  3. Protein phosphatase 6 ( (show NFKB1 Proteins)ppp6c), a ne (show MLXIP Proteins)gative regulator that restricts the G1 to S phase progression, is diminished in human psoriatic epidermis and is directly targeted by miR-31.

  4. PP6 is involved in a diverse set of biological pathways.

  5. These results suggest that human PP6 interacts with and positively regulates the activity of the influenza A virus RNA-dependent RNA polymerase.

  6. PP6C mutations have distinct functional and clinical consequences in melanoma, and confer sensitivity to Aurora A kinase (show AURKA Proteins) inhibitors.

  7. PP6c associates with E-cadherin (show CDH1 Proteins) in adherens junctions and is required to oppose casein kinase-1 (show CSNK1A1 Proteins) to maintain cell surface localization of E-cadherin (show CDH1 Proteins).

  8. Findings support the view that formation of micronuclei rather than chromosome instability alone explains how loss of PPP6C, and more generally mitotic spindle and centrosome defects, can act as drivers for genome instability in melanoma.

  9. Results show that Sit4p and its mammalian orthologue, PP6, regulate traffic from the ER to the Golgi complex which is consistent with its role in coat recycling.

  10. PP2A (show PPP2R4 Proteins) holoenzyme and PP6 were found stably associated with U1 snRNP (show LSM2 Proteins); findings indicate that these phosphatases regulate splicing catalysis involving U1 snRNP (show LSM2 Proteins) and suggest an important evolutionary conserved role of PP2A (show PPP2R4 Proteins) family phosphatases in pre-mRNA splicing

Mouse (Murine) Protein Phosphatase 6, Catalytic Subunit (PPP6C) interaction partners

  1. findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility.

  2. Data identify NF-kappaB (show NFKB1 Proteins)-induced miR (show MLXIP Proteins)-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis.

  3. Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA.

  4. Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 (show TP53 Proteins)

  5. Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis

  6. PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM.

  7. alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A (show PPP2R2B Proteins) and PP6 [PP6]

Protein Phosphatase 6, Catalytic Subunit (PPP6C) Protein Profile

Protein Summary

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.

Gene names and symbols associated with PPP6C

  • Protein phosphatase V (PpV)
  • hypothetical LOC464731 (PPP6C)
  • protein phosphatase 6, catalytic subunit (PPP6C)
  • protein phosphatase V (ppp6c)
  • protein phosphatase 6, catalytic subunit (ppp6c)
  • protein phosphatase 6 catalytic subunit (ppp6C)
  • serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6c)
  • protein phosphatase 6, catalytic subunit (Ppp6c)
  • 2310003C10Rik protein
  • CG12217 protein
  • DDBDRAFT_0168786 protein
  • DDBDRAFT_0185210 protein
  • DDB_0168786 protein
  • DDB_0185210 protein
  • Dmel\\CG12217 protein
  • DmPpV-6A protein
  • dPP6 protein
  • MGC114734 protein
  • pp6 protein
  • PP6C protein
  • ppp6c protein
  • PPPV6A protein
  • Ppv protein
  • PPV 6A protein
  • zgc:56227 protein

Protein level used designations for PPP6C

CG12217-PA , CG12217-PB , CG12217-PC , CG12217-PD , PpV-PA , PpV-PB , PpV-PC , PpV-PD , protein phosphatase V , protein phosphatase 6, catalytic subunit , serine/threonine-protein phosphatase 6 catalytic subunit , serine/threonine-protein phosphatase 6 catalytic subunit-like , serine/threonine protein phosphatase catalytic subunit , PP6C , PP-V

GENE ID SPECIES
31582 Drosophila melanogaster
464731 Pan troglodytes
479534 Canis lupus familiaris
549864 Xenopus (Silurana) tropicalis
703658 Macaca mulatta
720872 Macaca mulatta
734439 Xenopus laevis
738446 Pan troglodytes
772354 Gallus gallus
8618444 Dictyostelium discoideum AX4
100015864 Monodelphis domestica
100070914 Equus caballus
100074888 Ornithorhynchus anatinus
100153256 Sus scrofa
100169448 Acyrthosiphon pisum
100479321 Ailuropoda melanoleuca
5537 Homo sapiens
67857 Mus musculus
511058 Bos taurus
171121 Rattus norvegicus
393980 Danio rerio
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