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Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Proteins (PTPN5)

May regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (By similarity).. Additionally we are shipping Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Antibodies (84) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPN5 29644 P35234
PTPN5 19259 P54830
PTPN5 84867 P54829
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Top Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,010.33
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PTPN5 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , ,
,

More Proteins for Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) Interaction Partners

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) interaction partners

  1. STEP61 regulates BDNF (show BDNF Proteins) expression, with implications for cognitive functioning in CNS disorders.

  2. The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2 (show MAPK1 Proteins).

  3. These results indicate that STEP61 is a novel substrate of parkin (show PARK2 Proteins), although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD.

  4. Abeta (show APP Proteins) regulating STEP61 activity is mediated by Abeta (show APP Proteins) binding to alpha7 nAChRs

  5. Increased STEP and calpain activation contribute to altered NMDAR (show GRIN1 Proteins) localization in an Huntington's disease mouse model.

  6. genetically reducing STEP significantly diminishes seizures and restores select social and nonsocial anxiety-related behaviors in Fmr1 (show FMR1 Proteins)(KO) mice

  7. the first study to identify Pyk2 (show PTK2B Proteins) as a substrate for STEP.

  8. Increased STEP61 plays a role in (show APP Proteins)amyloid Abeta-mediated internalization of th (show GRIA1 Proteins)e (AMP (show GRIA2 Proteins)AR) subuni (show GRIN1 Proteins)ts GluA1/GluA2 (formerly GluR1/GluR2).

  9. STEP pathway is severely downregulated in the presence of mutant huntingtin (show HTT Proteins) and may participate in compensatory mechanisms activated by striatal neurons that lead to resistance to excitotoxicity.

  10. Electrical stimulation of the hippocampal-entorhinal cortex pathway in STEP knockout mice resulted in less activation of the dentate gyrus granule cell layer (GCL), but greater activation of the hilus in STEP knockouts, compared with heterozygous slices.

Human Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) interaction partners

  1. A rare missense variant in the PTPN5 gene (rs56234898; minor allele frequency 1.5%) was significantly associated with decreased severity of Post-Burn Hypertrophic Scarring(P = 1.3x10-6).

  2. The results imply a model in which PTPN5 may play a role in normal cognitive functioning and contribute to aspects of the neuropathology of schizophrenia.

  3. This study identified a novel role for PTPN5 in mediating the development of stress-related cognitive and morphological changes.

  4. STEP(61kDa) is required for Abeta (show APP Proteins) transgene-mediated internalization of GluA1 (show GRIA1 Proteins)/GluA2 (show GRIA2 Proteins) glutamate (show GRIN1 Proteins) receptors in a transgenic mousemodel.

  5. STEP contributes to aspects of the pathophysiology in Alzheimer's disease; loss of GluN1 (show GRIN1 Proteins)/GluN2B (show GRIN2B Proteins) subunits from neuronal membranes and Abeta (show APP Proteins)-mediated NMDAR (show GRIN1 Proteins) internalization are discussed

  6. determined high-resolution structures of all of the human family members of Mitogen-Activated Protein Kinase (show MAPK1 Proteins)-specific protein tyrosine phosphatases

Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) Protein Profile

Protein Summary

May regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (By similarity).

Gene names and symbols associated with PTPN5

  • protein tyrosine phosphatase, non-receptor type 5 (ptpn5)
  • protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) (PTPN5)
  • protein tyrosine phosphatase, non-receptor type 5 (Ptpn5)
  • PTPSTEP protein
  • Step protein

Protein level used designations for PTPN5

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) , tyrosine-protein phosphatase non-receptor type 5 , neural-specific protein-tyrosine phosphatase , protein-tyrosine phosphatase striatum-enriched , protein-tyrosine-phosphatase non-receptor 5 , striatum-enriched protein-tyrosine phosphatase

GENE ID SPECIES
559524 Danio rerio
423085 Gallus gallus
615850 Bos taurus
29644 Rattus norvegicus
19259 Mus musculus
84867 Homo sapiens
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