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The protein encoded by PTPRH is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRH Antibodies (29) and PTPRH Kits (11) and many more products for this protein.
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PTPRH is overexpressed in non-small cell lung cancer, is regulated by DNA hypomethylation, and PTPRH DNA methylation (show HELLS Proteins) was an independent prognostic factor
SAP-1 (show ELK4 Proteins) induces apoptotic cell death by inhibition of cell survival signaling mediated by PI 3 (show PI3 Proteins)-kinase, Akt (show AKT1 Proteins), and ILK (show ILK Proteins) and activation of a caspase (show CASP3 Proteins)-dependent proapoptotic pathway.
SAP-1 expression is downregulated during the dedifferentiation of human hepatocellular carcinoma, which may play a causal role in disease progression
SAP-1 and CEACAM20 thus constitute a regulatory system through which the intestinal epithelium contributes to intestinal immunity.
These results thus suggest that SAP-1 (show ELK4 Proteins) is a microvillus-specific receptor-type protein tyrosine phosphatase (show ACP1 Proteins) that regulates intestinal tumorigenesis.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants.
, receptor-type tyrosine-protein phosphatase H
, stomach cancer-associated protein tyrosine phosphatase 1
, transmembrane-type protein-tyrosine phosphatase type H
, receptor type protein tyrosine phosphatase sap-1
, brain-enriched membrane-associated protein tyrosine BEM-2