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Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Proteins (PCMT1)

PCMT1 encodes a member of the type II class of protein carboxyl methyltransferase enzymes. Additionally we are shipping Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies (52) and Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCMT1 5110 P22061
PCMT1 18537  
PCMT1 25604 P22062
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Top Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,570.33
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details

PCMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Interaction Partners

Human Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

  1. Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma.

  2. The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death

  3. ERK2 (show MAPK1 Proteins)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Proteins) at Ser298 augments hepatic gluconeogenesis.

  4. Overexpression of PCMT1 attentuates Mst1 (show MST1 Proteins) kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes.

  5. Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp, and is able to restore Arabidopsis PRH75's complex biochemical activity provided isoAsp formation has not led to conformational alterations.

  6. Data show six differentially expressed proteins were identified as HSP70 (show HSP70 Proteins), PPIA (show PPIA Proteins) and alpha-Enolase (show ENO1 Proteins) (up-regulated) S100-A9, PIMT and beta-5 tubulin (show TUBB Proteins) (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis.

  7. The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang.

  8. Study provides new insight into the molecular mechanisms by which PIMT suppresses the p53 (show TP53 Proteins) activity through carboxyl methylation, and suggests a therapeutic target for cancers.

  9. PIMT may act as a co-activator in ERalpha (show ESR1 Proteins)-mediated transcription of TFF1 (show TFF1 Proteins) through its recruitment to the promoter via interacting with ERalpha (show ESR1 Proteins).

  10. Control of PCMT1 expression by microRNA 15a/16-1 may thus represent a late checkpoint in apoptosis regulation

Mouse (Murine) Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

  1. Loss of normal CKB (show CHKB Proteins) structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.

  2. PIMT levels may significantly influence the course of age-related central nervous system dysfunction.

  3. ERK2 (show MAPK1 Proteins)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Proteins) at Ser298 augments hepatic gluconeogenesis.

  4. PIMT knockout mice have perturbations in glutamate (show GRIN1 Proteins) metabolism in the brain and die prematurely of epileptic seizures.

  5. synuclein is not a major target of PIMT in vivo

  6. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of PCMT1 knockout mice

  7. Recombinant adeno (show ADORA2A Proteins)-PIMT improved the symptoms of PIMT-deficient mice in vivo, but only partially repaired IsoAsp in damaged proteins.

  8. An accumulation of isoaspartyl residues in cells of mice lacking the isoaspartyl repair enzyme PCMT alters the effector function of T lymphocytes leading to autoantibody production.

  9. Pcmt1-/- mice have altered regulation of the insulin (show INS Proteins) pathway, possibly as a compensatory response to altered glucose uptake or metabolism or as an adaptive response to a general accumulation of isoaspartyl protein damage in the brain and other tissues.

  10. Protein L-isoaspartyl methyltransferase (PIMT) catalyzes in vivo racemization of Asp (show C3 Proteins)-25 in mammalian histone H2B, suggesting that PIMT functions in the repair, rather than the metabolic turnover, of isoaspartyl proteins in vivo.

Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Protein Profile

Protein Summary

This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PCMT1

  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (pcmt1)
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1)
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (Pcmt1)
  • C79501 protein
  • PCM protein
  • PCMT protein
  • PIMT protein

Protein level used designations for PCMT1

L-isoaspartyl protein carboxyl methyltransferase , PIMT , protein L-isoaspartyl/D-aspartyl methyltransferase , protein-L-isoaspartate(D-aspartate) O-methyltransferase , protein-beta-aspartate methyltransferase , protein carboxyl-o-methyltransferase , protein carboxyl methyltransferase

GENE ID SPECIES
495685 Xenopus laevis
428607 Gallus gallus
5110 Homo sapiens
476242 Canis lupus familiaris
100502562 Sus scrofa
613854 Bos taurus
100172708 Pongo abelii
18537 Mus musculus
25604 Rattus norvegicus
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