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Proteinase 3 Proteins (PRTN3)

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.. Additionally we are shipping Proteinase 3 Antibodies (186) and Proteinase 3 Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRTN3 5657 P24158
PRTN3 314615  
PRTN3 19152 Q61096
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Top Proteinase 3 Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag Proteinase 3 (PRTN3) (AA 28-248), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Human Human Un-conjugated 25 μg Log in to see 2 to 3 Days
$309.75
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$457.60
Details
HOST_Human Human Un-conjugated   200 μg Log in to see 7 to 9 Days
$707.50
Details
HOST_Human Human Un-conjugated   100 μg Log in to see 7 to 9 Days
$777.50
Details

PRTN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Proteinase 3 (PRTN3) Interaction Partners

Human Proteinase 3 (PRTN3) interaction partners

  1. miR (show MLXIP Proteins)-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 (show ADAM17 Proteins) and IL-6 (show IL6 Proteins) in Proteinase-3 ANCA-Associated Vasculitis

  2. The PR3-induced microenvironment facilitated recruitment of inflammatory cells, such as macrophages, plasmacytoid DCs (pDCs), and neutrophils, which were observed in close proximity within granulomatous lesions in the lungs of GPA patients.

  3. ACPA negative rheumatoid arthritis shares the genetic susceptibility loci with ACPA positive disease.

  4. Data suggest that targeting proteinase-3 (PR3) specific effector memory cells, to prevent relapse, and instituting anti IL-17 (show IL17A Proteins) therapy, or modulating Tregs could be newer forms of therapy for granulomatosis with polyangiitis (GPA (show GYPA Proteins)).

  5. Anti-PR3 autoantibodies not detected in sera of patients with pulmonary tuberculosis.

  6. these results highlight a potentially important role for proteinase 3 in emphysema.

  7. The data shows that the neutrophil protease PR3 is a direct modulator of human platelets and causes shape change through activation of the Rho/Rho kinase (show ROCK1 Proteins) and Ca(2 (show CA2 Proteins)+) signaling pathways.

  8. These in vivo data provide, for the first time, compelling evidence of the collateral involvement of cathepsin G (show CTSG Proteins), NE, and proteinase 3 in cigarette smoke-induced tissue damage and emphysema

  9. Proteinase 3-mediated caspase-3 (show CASP3 Proteins) activation controls neutrophil spontaneous death

  10. Elevated levels of GCF (show GUCY2F Proteins) proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response.

Mouse (Murine) Proteinase 3 (PRTN3) interaction partners

  1. In different murine models of apoptotic cell injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation.

  2. PR3-ANCA is a promising biomarker in primary sclerosing cholangitis.

  3. Proteinase 3-mediated caspase-3 (show CASP3 Proteins) activation controls neutrophil spontaneous death

  4. Increased PRTN3 activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  5. Phagocytosis of apoptotic PR3-expressing cells potentiates proinflammatory cytokines in vivo by resident murine peritoneal macrophages.

  6. the dual functions (activation/termination) of PR3 in IL-33 (show IL33 Proteins) biological activity.

  7. pathogenic effect of proteinase 3-specific antineutrophil cytoplasmic autoantibodies at local sites of inflammation.

  8. Murine and human proteinase 3 complexes have different interaction patterns with peptidic substrates.

  9. PR3 and neutrophil elastase (show ELANE Proteins) enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of progranulin (show GRN Proteins). Our results support the use of serine protease (show F2 Proteins) inhibitors as antiinflammatory agents.

  10. Neutrophil-derived PR3 can proteolyze high-molecular weight kininogen and liberate PR3-kinin, thereby initiating kallikrein (show KLK1 Proteins)-independent activation of the kinin pathway

Proteinase 3 (PRTN3) Protein Profile

Protein Summary

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Gene names and symbols associated with Proteinase 3 Proteins (PRTN3)

  • proteinase 3 (prtn3)
  • proteinase 3 (PRTN3)
  • proteinase 3 (Prtn3)
  • ACPA protein
  • AGP7 protein
  • C-ANCA protein
  • CANCA protein
  • ela2 protein
  • MBN protein
  • MBT protein
  • MGC132250 protein
  • mPR3 protein
  • NP-4 protein
  • NP4 protein
  • P29 protein
  • PR-3 protein
  • PR3 protein

Protein level used designations for Proteinase 3 Proteins (PRTN3)

proteinase 3 , C-ANCA antigen , Wegener granulomatosis autoantigen , azurophil granule protein 7 , leukocyte proteinase 3 , myeloblastin , neutrophil proteinase 4 , serine proteinase, neutrophil , wegener autoantigen , PR-3

GENE ID SPECIES
496090 Xenopus laevis
5657 Homo sapiens
314615 Rattus norvegicus
19152 Mus musculus
100298591 Bos taurus
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