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anti-Proteolipid Protein 1 (PLP1) Antibodies

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. Additionally we are shipping Proteolipid Protein 1 Kits (21) and Proteolipid Protein 1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLP1 18823 P60202
PLP1 5354 P60201
PLP1 24943 P60203
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Top anti-Proteolipid Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-PLP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-PLP1 antibody (ARP33843_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PLP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Mouse Un-conjugated FACS, IHC (fro), IF, IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$533.50
Details
Cow Mouse Un-conjugated IHC (fro), IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PLP1 antibody ABIN364261 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with PLP1 antibody ABIN364261 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged PLP1 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Mouse Un-conjugated IHC, WB 0.05 mg Log in to see 2 to 3 Days
$481.25
Details
Human Mouse Un-conjugated ICC, IHC (fro), IHC (p), WB Anti-PLP1 antibody IHC staining of human brain cerebellum, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1103681 dilution 10 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-PLP1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959011 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB PLP1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

PLP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , ,
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Human , ,
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Rat (Rattus)
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Top referenced anti-Proteolipid Protein 1 Antibodies

  1. Cow (Bovine) Monoclonal PLP1 Primary Antibody for FACS, IHC (fro) - ABIN119026 : Grade, Agasse, Bernardino, Silva, Cortes, Malva: Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin. in Rejuvenation research 2010 (PubMed)
    Show all 11 references for ABIN119026

  2. Chicken Polyclonal PLP1 Primary Antibody for IHC, WB - ABIN2778151 : Regis, Biancheri, Bertini, Burlina, Lualdi, Bianco, Devescovi, Rossi, Uziel, Filocamo: Genotype-phenotype correlation in five Pelizaeus-Merzbacher disease patients with PLP1 gene duplications. in Clinical genetics 2008 (PubMed)

More Antibodies against Proteolipid Protein 1 Interaction Partners

Mouse (Murine) Proteolipid Protein 1 (PLP1) interaction partners

  1. In the absence of P0, thus, PLP (show C3 Antibodies) also contributes to myelination by Schwann cells and to the preservation of peripheral axons

  2. while PLP (show C3 Antibodies) can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP (show C3 Antibodies) cannot replace P0 as the major structural protein of PNS myelin.

  3. Both extracellular and intracellular epitopes of PLP (show C3 Antibodies) contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin.

  4. The insertion of native PLP (show C3 Antibodies) into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate.

  5. This study shows for the first time that Plp (show C3 Antibodies)-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior.

  6. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4 (show CD4 Antibodies)+ T cell responses in a T cell-mediated autoimmune disease.

  7. that an early reactive glia response occurs following mutations in the PLP (show C3 Antibodies) gene

  8. Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth.

  9. PLP (show C3 Antibodies) significantly suppresses both models of experimental autoimmune encephalitis (EAE)even when there is some evidence of epitope spreading in the myelin oligodendrocyte (MOG (show MOG Antibodies))38-50-induced EAE model.

  10. PLP (show C3 Antibodies) contributes to the high cholesterol content of myelin by association and co-transport in the central nervous system.

Human Proteolipid Protein 1 (PLP1) interaction partners

  1. Identification and functional study of novel PLP1 mutations in Chinese patients with Pelizaeus-Merzbacher disease. We identified PLP1 mutations in seven male patients with PMD.

  2. In major depressive disorder there was a significantly reduced expression of PLP1 mRNA.

  3. Study investigated 17 unrelated Pelizaeus-Merzbacher disease subjects with copy number gains at the PLP1 locus including triplication and quadruplication of specific genomic intervals-16/17 were found to have a duplication-inverted triplication-duplication rearrangement product.

  4. Myelin proteolipid protein is critical to regulating oligodendrocyte progenitor cell migration.

  5. PLP1 splicing mutations may result in a wide variety of disease phenotypes through a combination of multiple molecular pathogenic mechanisms.

  6. this study provides new insight into the genotype-phenotype correlations of patients with PLP1 splice-site mutations.

  7. Insertion of an extra copy of Xq22.2 into 1p36 results in functional duplication of the PLP1 gene in a girl with classical Pelizaeus-Merzbacher disease.

  8. Data strongly suggest that a secondary structure within intron 3 is important for controlling regulation of the PLP1 alternative splice and that patient mutations can cause Pelizaeus-Merzbacher disease by disrupting this structure.

  9. Mutations found in the PLP1 gene are the cause of PMD in around 20% of the patients in this series.

  10. Data suggest transmembrane segment of PLP contains multiple helix-helix interaction motifs that play role in ability of PLP to form dimers/oligomers; alteration of local hydrophobicity affects both helix-helix interaction and segment alpha-helicity.

Proteolipid Protein 1 (PLP1) Antigen Profile

Protein Summary

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene names and symbols associated with PLP1

  • proteolipid protein 1 (PLP1) antibody
  • proteolipid protein 1 (plp1) antibody
  • myelin proteolipid protein (Tsp_11640) antibody
  • myelin proteolipid protein (plp) antibody
  • proteolipid protein (myelin) 1 (Plp1) antibody
  • proteolipid protein 1 (Plp1) antibody
  • proteolipid protein 1 (plp1-a) antibody
  • DKFZp459O081 antibody
  • DKFZp459O113 antibody
  • DM20 antibody
  • GPM6C antibody
  • hld1 antibody
  • jimpy antibody
  • jp antibody
  • mmpl antibody
  • msd antibody
  • Plp antibody
  • PLP/DM20 antibody
  • plp1 antibody
  • plp1a antibody
  • pmd antibody
  • rsh antibody
  • spg2 antibody

Protein level used designations for PLP1

proteolipid protein 1 , proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , myelin proteolipid protein , lipophilin , myelin synthesis deficiency , rump shaker , major myelin proteolipid protein , Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated) , Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein (myelin) 1 , PLP , proteolipid protein, lipophilin , PLP-A , lipophilin-A , myelin proteolipid protein (PLP) , myelin proteolipid protein A , proteolipid protein 1 a

GENE ID SPECIES
465785 Pan troglodytes
613099 Xenopus (Silurana) tropicalis
752012 Taeniopygia guttata
100173486 Pongo abelii
100174736 Pongo abelii
10903177 Trichinella spiralis
100136749 Oncorhynchus mykiss
18823 Mus musculus
5354 Homo sapiens
281410 Bos taurus
24943 Rattus norvegicus
396214 Gallus gallus
481002 Canis lupus familiaris
397029 Sus scrofa
100009169 Oryctolagus cuniculus
398334 Xenopus laevis
100220245 Taeniopygia guttata
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