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anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) Antibodies

PIM2 encodes a protooncogene that acts as a serine/threonine protein kinase. Additionally we are shipping Proto-Oncogene Pim-2 (Serine Threonine Kinase) Proteins (13) and Proto-Oncogene Pim-2 (Serine Threonine Kinase) Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PIM2 11040 Q9P1W9
PIM2 317366  
PIM2 18715 Q62070
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Top anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), IP, WB Western blot analysis of anti-PIM2 Antibody (C-term) (ABIN392442) in Hela cell line lysates (35 µg/lane). PIM2 (arrow) was detected using the purified polyclonal antibody. PIM proteins were immunoprecipitated from MV4.11 cells and the agarose-protein A-immunoprecipitate complex was tested for its ability to phosphorylate BAD in vitro in the presence or absence of K00135. Phosphorylation of BAD (both on Ser112 and Ser136, detected by WB with phospho-specific antibodies) was abrogated on addition of the compound. Asterisks, strong bands corresponding to the heavy chain of the anti-PIM2 rabbit antibody recognized by the antirabbit immunoglobulin G secondary antibody. Beads alone (without anti-PIM antibodies) were incubated with the MV4.11 extract and used for the same in vitro phosphorylation reaction as a negative control. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PIM2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate WB Suggested Anti-PIM2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 6 to 8 Days
$599.50
Details
Human Goat Un-conjugated ELISA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tag probed with ABIN1590033 (0.1 µg/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with ABIN1590033 (0.1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated ELISA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tag probed with ABIN1590101 (0.1 µg/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with ABIN1590101 (0.1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB Immunohistochemical staining of paraffin-embedded Human colon tissue using anti-PIM2 mouse monoclonal antibody. (ABIN2453464, Dilution 1:50) Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-PIM2 mouse monoclonal antibody. (ABIN2453464, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, IP, IHC, WB Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-RC201933 mouse monoclonal antibody. (ABIN2453466, Dilution 1:50) Immunohistochemical staining of paraffin-embedded liver tissue using anti-RC201933 mouse monoclonal antibody. (ABIN2453466, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IHC, WB Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-RC201933 mouse monoclonal antibody. (ABIN2453470, Dilution 1:50) Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-RC201933 mouse monoclonal antibody. (ABIN2453470, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), IP, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details

PIM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) Antibodies

  1. Human Polyclonal PIM2 Primary Antibody for EIA, IHC (p) - ABIN360329 : Sato, Torigoe, Hirohashi, Kitamura, Tanaka, Honma, Asanuma, Harada, Takasu, Masumori, Ito, Hasegawa, Tsukamoto, Sato: Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)

  2. Human Polyclonal PIM2 Primary Antibody for IHC (p), IP - ABIN392442 : Pogacic, Bullock, Fedorov, Filippakopoulos, Gasser, Biondi, Meyer-Monard, Knapp, Schwaller: Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. in Cancer research 2007 (PubMed)

More Antibodies against Proto-Oncogene Pim-2 (Serine Threonine Kinase) Interaction Partners

Zebrafish Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. Inhibition of the Pim1 (show PIM1 Antibodies) oncogene (show RAB1A Antibodies) results in diminished visual function.

Human Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. We show that Pim2 inhibitors and proteasome inhibitors, such as bortezomib, have additive effects to inhibit the growth of myeloma cells, suggesting that Pim2 could be an interesting target for the treatment of multiple myeloma.

  2. PIM2 gene knockdown enhances the anti-proliferative effect of AZD1208 in non-Hodgkin lymphoma cell line.

  3. A high percentage of urothelial carcinomas express Pim (show PIM1 Antibodies) kinases. Pim (show PIM1 Antibodies) expression differs in NILG, NIHG, and IHG lesions.

  4. Our findings suggest that Pim-2-mediated aerobic glycolysis is critical for monitoring Warburg effect in colorectal tumor cells, highlighting Pim-2 as a potential metabolic target for colorectal tumor therapy.

  5. our findings will help to uncover novel signaling pathways between inflammations and oxidative stress in rheumatoid arthritis development and imply that Pim-2/mTORC1 pathway may be critical for the initiation of inflammatory reactions.

  6. Persistent activation of STAT3 (show STAT3 Antibodies) by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer.

  7. Data demonstrate the role of PIM (show PIM1 Antibodies) kinases in driving myeloid leukemia (show BCL11A Antibodies), and as candidate molecules for therapy against human malignancies.

  8. Blocking the activities of PIM (show PIM1 Antibodies) kinases(PIM1 (show PIM1 Antibodies), PIM2 and PIM3 (show PIM3 Antibodies)) could prevent pancreatic cancer development. PIM (show PIM1 Antibodies) kinases(PIM1 (show PIM1 Antibodies), PIM2 and PIM3 (show PIM3 Antibodies)) may be a novel target for cancer therapy

  9. HIF-1A (show HIF1A Antibodies) induced PIM2 expression in HepG2 cells via binding to the hypoxia-responsive elements (HREs) of the PIM2 promoter.

  10. PIM2 could directly phosphorylate PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels. Compared with wild type, PKM2 with the phosphorylation-defective mutation displayed a reduced effect on glycolysis.

Mouse (Murine) Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. studies define a pathway for limiting the regulation of Foxp3 (show FOXP3 Antibodies) function because the Pim-2 kinase represents a potential therapeutic target for modulating the Treg cell suppressive activities in controlling immune responses

  2. Pim2 facilitated allograft rejection primarily by modulating the apoptosis of effector T cells and the function of regulatory T cells.

  3. Loss of PIM2 is associated with abnormal hematopoietic phenotypes.

  4. signals from IL-7 (show IL7 Antibodies) and RAG DSBs activate distinct Pim (show PIM1 Antibodies) kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival.

  5. Targeting cap-dependent translation blocks converging survival signals by AKT (show AKT1 Antibodies) and PIM 1 (show PIM1 Antibodies), 2 kinases in lymphoma

  6. PIM2 controls the expression of the pro-inflammatory cytokine IL-6 (show IL6 Antibodies).

  7. results support the hypothesis that Pim2, which is also a known target of Flt3 (show FLT3 Antibodies)-ITD (another gene that cooperates with PML (show PML Antibodies)-RARalpha (show RARA Antibodies)), cooperates with PRalpha to induce acute promyelocytic leukemia (show PML Antibodies)-like disease

  8. Pim-2 is a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival

  9. pim-2 functions similarly to pim-1 (show PIM1 Antibodies) as a pro-survival kinase; BAD is a legitimate PIM-2 substrate

  10. Pim-2 and Akt-1 (show AKT1 Antibodies) are critical components of overlapping but independent pathways, either of which is sufficient to promote the growth and survival of nontransformed hematopoietic cells

Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) Antigen Profile

Protein Summary

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.

Gene names and symbols associated with PIM2

  • pim-1 oncogene (pim1) antibody
  • pim-2 oncogene (PIM2) antibody
  • pim-2 oncogene (Pim2) antibody
  • proviral integration site 2 (Pim2) antibody
  • cb1068 antibody
  • DXCch3 antibody
  • fj47b05 antibody
  • Pim-2 antibody
  • pim2 antibody
  • wu:fj47b05 antibody

Protein level used designations for PIM2

kinase pim-1 , proviral integration site 2 , serine/threonine-protein kinase Pim-1 , serine/threonine-protein kinase pim-2 , pim-2h , proto-oncogene Pim-2 (serine threonine kinase) , serine/threonine protein kinase pim-2 , serine/threonine kinase

GENE ID SPECIES
58054 Danio rerio
11040 Homo sapiens
442959 Canis lupus familiaris
508424 Bos taurus
317366 Rattus norvegicus
473600 Pan troglodytes
18715 Mus musculus
Selected quality suppliers for anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) Antibodies
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