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The product of P2RX3 belongs to the family of purinoceptors for ATP. Additionally we are shipping Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins (6) and many more products for this protein.
Showing 10 out of 69 products:
Human Polyclonal P2RX3 Primary Antibody for ICC, FACS - ABIN250458
Tamburro, Fredolini, Espina, Douglas, Ranganathan, Ilag, Zhou, Russo, Espina, Muto, Petricoin, Liotta, Luchini: Multifunctional core-shell nanoparticles: discovery of previously invisible biomarkers. in Journal of the American Chemical Society 2011
Show all 3 references for ABIN250458
Human Polyclonal P2RX3 Primary Antibody for IHC, IHC (fro) - ABIN250462
Kaan, Yip, Patel, Davies, Marchand, Cockayne, Nunn, Dickenson, Ford, Zhong, Malcangio, McMahon: Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. in Brain : a journal of neurology 2010
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P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy.
X-ray crystal structures of the human P2X3 receptor in apo (show C9orf3 Antibodies)/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states
there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor (show P2RX7 Antibodies) in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.
Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor (show P2RX1 Antibodies) hP2X2/3 channel.
Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC (show FAM126A Antibodies)) therapy.
Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (show P2RX2 Antibodies) and P2X3 subunits
Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.
The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2 (show P2RX2 Antibodies), P2X3 and P2X7 (show P2RX7 Antibodies) receptors in the different histological layers of the human urinary bladder.
sensory proteins P2X3 and TRPV1 (show TRPV1 Antibodies) are in correlation with urothelial differentiation, while P2X5 (show P2RX5 Antibodies) and TRPV4 (show TRPV4 Antibodies) have unique expression patterns
esophagitis increases mRNA expressions of P2X3 and P2X7 (show P2RX7 Antibodies) receptors accompanied by up-regulation of TRPV1 (show TRPV1 Antibodies) and neurotrophic factors (NGF (show NGFB Antibodies) and GDNF (show GDNF Antibodies)).
Data suggest that the negative inhibition of P2X3R activity by the BNP (show BNC2 Antibodies)/NPR-A (show NPR1 Antibodies) pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide (show BNP Antibodies) and facilitatory calcitonin gene-related peptide (show CALCA Antibodies) that both operate via complex intracellular signaling.
mouse trigeminal neurons endogenous BNP (show BNC2 Antibodies) acts on NPR-A (show NPR1 Antibodies) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP (show BNC2 Antibodies)/NPR-A (show NPR1 Antibodies)/PKG (show PRKG1 Antibodies) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments
This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (show P2RX2 Antibodies)/P2X3 knockout mice.
a slow modulatory action by BNP (show BNC2 Antibodies) on TRPV1 (show TRPV1 Antibodies) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin
genetic manipulation of TRPV1 (show TRPV1 Antibodies) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.
up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (show CALCA Antibodies) and BDNF (show BDNF Antibodies) levels
Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]
interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
purinergic receptor P2X, ligand-gated ion channel, 3
, P2X3 purinoceptor
, purinergic receptor P2X3
, ATP receptor
, P2X purinoceptor 3
, P2X receptor, subunit 3
, purinoceptor P2X3