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The protein encoded by PYHIN1 belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. Additionally we are shipping PYHIN1 Antibodies (29) and many more products for this protein.
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a new member of the hematopoietic interferon (show IFNA Proteins) (IFN)-inducible nuclear protein (show RDBP Proteins). Six different alternatively spliced forms are transcribed from the IFIX gene
IFIX alpha1 isoform functions as a tumor suppressor by repressing HDM2 function
IFIXalpha suppressed the invasion activity of MDA-MB-468 breast cancer cells, and its inhibitory effect was reversed by the knockdown of maspin (show SERPINB5 Proteins)
promotes LPS (show TLR4 Proteins)-induced IFN-beta (show IFNB1 Proteins) and NO production in macrophages
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
pyrin and HIN domain family, member 1
, interferon-inducible protein X
, pyrin and HIN domain-containing protein 1
, interferon-inducible protein 209
, interferon-inducible protein p209