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Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. Additionally we are shipping RAE1 Proteins (10) and many more products for this protein.
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Human Polyclonal RAE1 Primary Antibody for IHC (p), IHC - ABIN250559
Blower, Nachury, Heald, Weis: A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. in Cell 2005
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D (show KLRK1 Antibodies) ligands. RAE-1 is transcriptionally repressed by histone deacetylase (show HDAC1 Antibodies) inhibitor 3 (show PPP1R11 Antibodies) (HDAC3 (show HDAC3 Antibodies)) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (show CSNK2A1 Antibodies) and preventing it from activating HDAC3 (show HDAC3 Antibodies).
High RAE1 expression is associated with lymphoma.
Viral infection of cultured cells increased RAE-1 expression, resulting in enhanced NK cell-mediated killing through NKG2D (show KLRK1 Antibodies) recognition.
An increased expression of the NKG2D (show KLRK1 Antibodies) ligand MICA (show MICA Antibodies) in systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and Mult-1 (show ULBP1 Antibodies) in various murine SLE models, is reported.
Desiccating stress-induced chemokine (show CCL1 Antibodies) expression in the epithelium is dependent on upregulation of NKG2D (show KLRK1 Antibodies)/RAE-1 and release of IFN-gamma (show IFNG Antibodies) in experimental dry eye.
Highly target-specific liver NKT (show CTSL1 Antibodies) cells selectively remove activated hepatic stellate cells through an NKG2D (show KLRK1 Antibodies)-Rae1 interaction to ameliorate liver fibrosis after IL-30 treatment.
Results suggest that genomic damage in tumor cells leads to activation of STING-dependent DNA sensor pathways, thereby activating RAE1 and enabling tumor immunosurveillance.
GM-SCF (show KITLG Antibodies), IL-21 (show IL21 Antibodies) and Rae1 expression, alone or in combination, induces a cellular immune response against H22 tumor cells.
mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion
Expression of RAE-1 proteins on erythroblast surfaces increased early after Friend virus inoculation and infected erythroid cells are recognized by natural killer cells mainly through the NKG2D (show KLRK1 Antibodies)-RAE-1 interactions in vivo.
Nuclear export inhibition by ORF10 of human herpesvirus 8 requires an interaction with an RNA export factor, Rae1.
After PSK (show TAOK2 Antibodies) administration, INF (show GIF Antibodies)-g production in CD8 (show CD8A Antibodies)(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model
Vesiculoviral matrix (M) protein (show MYOM2 Antibodies) occupies nucleic acid binding site at nucleoporin (show AGFG2 Antibodies) pair (Rae1 * Nup98 (show NUP98 Antibodies)).
vesicular stomatitis virus M protein (show MYOM2 Antibodies) interacted efficiently with Rae1-Nup98 (show NUP98 Antibodies) complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription
This study established a novel postmitotic function for rae-1 in neuronal development.
RAE1 transgene orchestrates proper chromosome segregation and NUP98 (show NUP98 Antibodies)-mediated leukemogenesis.
In a transgenic mouse model of chronic natural killer NKG2D (show KLRK1 Antibodies) ligand expression, constant exposure to NKG2D (show KLRK1 Antibodies) ligand RNA export 1 homolog (Rae-1 epsilon (show RAET1E Antibodies)) does not functionally impair NK cells or CD8 (show CD8A Antibodies)-positive T cells in the context of viral infection.
present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 (show NUP98 Antibodies) at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops.
Interaction between Rae1 and cohesin subunit SMC1 (show SMC1A Antibodies) is required for proper spindle formation.
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
mRNA export factor
, mRNA-associated protein mrnp 41
, rae1 protein homolog
, RAE1 (RNA export 1, S.pombe) homolog
, RAE1 RNA export 1 homolog
, homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)
, mRNA export protein
, mRNA-associated protein MRNP 41
, mRNA-binding protein, 41-kD
, migration-inducing gene 14