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The protein encoded by RASA2 is member of the GAP1 family of GTPase-activating proteins. Additionally we are shipping and many more products for this protein.
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Human Monoclonal RASA2 Primary Antibody for IF, IP - ABIN968142
Maekawa, Li, Iwamatsu, Morishita, Yokota, Imai, Kohsaka, Nakamura, Hattori: A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions. in Molecular and cellular biology 1994
Human Polyclonal RASA2 Primary Antibody for IHC, IHC (p) - ABIN4313447
Arafeh, Qutob, Emmanuel, Keren-Paz, Madore, Elkahloun, Wilmott, Gartner, Di Pizio, Winograd-Katz, Sindiri, Rotkopf, Dutton-Regester, Johansson, Pritchard, Waddell, Hill, Lin, Hevroni, Rosenberg, Khan et al.: Recurrent inactivating RASA2 mutations in melanoma. ... in Nature genetics 2015
Recurrent inactivating RASA2 mutations are associated with melanoma.
GAP1m is a Ras GAP (show RASA1 Antibodies) that switches off Ras signalling. GAP1m undergoes a plasma membrane association following growth factor stimulation of PI 3 (show PI3 Antibodies)-kinase as a result of its PH domain binding to phosphatidylinositol 3,4,5-trisphosphate.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein\; a compound suggested to function as a second messenger.
GTPase-activating protein 1m
, GTPase-activating protein of RAS
, ras GTPase-activating protein 2