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RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009].. Additionally we are shipping RGMB Antibodies (71) and RGMB Kits (1) and many more products for this protein.
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Our results demonstrate that RGMB is an important inhibitor of non-small cell lung cancer metastasis and that low RGMB expression is a novel predictor or a poor prognosis.
Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC (show CA2 Proteins) mouse model and in human patients.
RGMB was down-regulation in non-small cell lung cancer.
Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF (show HGF Proteins) and BMP-7 (show BMP7 Proteins).
two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 (show NEO1 Proteins) receptors in a pH-dependent manner.
current data firstly revealed that RGMB may act as a negative regulator in breast cancer through BMP signaling
The expression of RGMA (show RGMA Proteins), RGMB and RGMC (show HFE2 Proteins) was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues
Reduced expression of RGMB in breast cancer was associated with breast cancer.
Study focused on the RGMa (show RGMA Proteins) and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa (show RGMA Proteins) and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa (show RGMA Proteins) and RGMb expression in cerebral cortex were also higher.
These results reveal RGMb as a novel regulator for Autosomal dominant polycystic kidney disease by promoting renal tubule branching and regulating BMP signaling pathway.
The results indicate that RGMB-neogenin (show NEO1 Proteins)-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the developing olfactory epithelium.
Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC (show SLC25A20 Proteins) mouse model and in human patients.
RGMb is a novel binding partner for PD-L2 (show PDCD1LG2 Proteins) and its engagement with PD-L2 (show PDCD1LG2 Proteins) promotes respiratory tolerance.
Dragon may impair tubular epithelial integrity and induce epithelial apoptosis both in vitro and in vivo.
Strong expression of RGMa (show RGMA Proteins), RGMb and Neogenin (show NEO1 Proteins) protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus.
Our data suggest a positive modulatory contribution of RGMb and bone morphogenetic protein signaling to neurite extension in vitro and early axonal regrowth after nerve injury in vivo and a negative effect of Noggin (show NOG Proteins).
Dragon is an important negative regulator of IL-6 expression in immune cells; Dragon-deficient mice may be a useful model for studying immune and inflammatory disorders.
A gene with promoter binding to the DNA binding domain of DRG11 (show DRGX Proteins); encodes a conserved developmentally regulated membrane-associated glycosyl-phosphatidylinositol-anchored protein which promotes dorsal root ganglion neuron adhesion.
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005
RGM domain family member B
, repulsive guidance molecule b
, repulsive guidance molecule B
, RGM domain family, member B
, RGM domain family, member B-like
, RGM domain family member B-like
, DRG11-responsive axonal guidance and outgrowth of neurite