anti-Recombination Activating Gene 1 (RAG1) Antibodies

The protein encoded by RAG1 is involved in activation of immunoglobulin V-D-J recombination. Additionally we are shipping RAG1 Kits (25) and RAG1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAG1 84600  
RAG1 5896 P15918
RAG1 19373 P15919
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Top anti-RAG1 Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Horse Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Western blot analysis using RAG1 mAb against human RAG1 recombinant protein. (Expected MW is 31.6 kDa) 0.1 mg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated WB Western blot analysis of Rag-1. Lysate from Jurkat cells was probed with anti- Rag-1 (clone G189-1417) at concentrations of 2.0, 1.0, and 0.5 myg/ml. The antibody identifies Rag-1 as a ~110 kDa band. 0.1 mg Log in to see 6 to 8 Days
$203.19
Details
Mouse Rabbit Un-conjugated ChIP, WB Western Blot: RAG1 Antibody [NBP1-74190] - Mouse Liver Lysate 1ug/ml Gel Concentration 6-18% 100 μL Log in to see 8 to 11 Days
$500.06
Details
Chicken Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Mouse Un-conjugated ELISA, WB ELISA: RAG1 Antibody (1D9) [NBP2-37449] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng); Western Blot: RAG1 Antibody (1D9) [NBP2-37449] - Western blot analysis using RAG1 mAb against HEK293 (1) and RAG1 (AA: 818-868)-hIgGFc transfected HEK293 (2) cell lysate. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

RAG1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RAG1 Antibodies

  1. Human Monoclonal RAG1 Primary Antibody for WB - ABIN967402 : Chun, Schatz, Oettinger, Jaenisch, Baltimore: The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. in Cell 1991 (PubMed)
    Show all 6 references for 967402

  2. Human Monoclonal RAG1 Primary Antibody for ELISA, WB - ABIN1098121 : Chen, Xiao, Zhang, Li, Liu, Zhao, Ma, Luo, Qiu, Huang, Korteweg, Gu: Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. in PLoS ONE 2011 (PubMed)
    Show all 2 references for 1098121

  3. Mouse (Murine) Polyclonal RAG1 Primary Antibody for ChIP, WB - ABIN4893588 : Zhou, Yu, Chang, Zhang, Zhou, Cammas, Sun: TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 references for 4893588

More Antibodies against RAG1 Interaction Partners

Pig (Porcine) Recombination Activating Gene 1 (RAG1) interaction partners

  1. Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID (show PRKDC Antibodies)) phenotype similar to that of rodents and humans.

  2. Piglets with biallelic mutations in either RAG1 or RAG2 (show RAG2 Antibodies) exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells.

Human Recombination Activating Gene 1 (RAG1) interaction partners

  1. Our findings suggest that mutations in RAG1, specifically the p.R474C variant, can be associated with relatively mild clinical symptoms or delayed occurrence of T cell and B cell deficiencies but may predispose to progressive multifocal leukoencephalopathy.

  2. This study compares T-cell development of patients with RAG1-dependent immune deficiencies, and elucidates important differences that help to explain the wide range of immunologic phenotypes that result from different mutations within the same gene of various patients.

  3. Agammaglobulinemia associated to nasal polyposis due to a hypomorphic RAG1 mutation

  4. mutation c.256_257delAA in RAG1 gene seems to occur quite frequently in the Polish patients with severe combined immunodeficiency (show PRKDC Antibodies) and may result in classical OS as well as in severe combined immunodeficiency (show PRKDC Antibodies) without clinical and laboratory features of OS when occurred in homozygous state

  5. study reported 4 patients with RAG1 deficiency: classic severe combined immune deficiency (SCID (show PRKDC Antibodies)) was seen in 2 patients, Omenn syndrome was observed in 1 patient and atypical SCID (show PRKDC Antibodies) was seen in one patient

  6. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

  7. These findings provide insight into the role of this poorly understood region of Rag1 and support the role of Rag1 in a post-cleavage stage of recombination

  8. Expression of recombinase RAG-1 in diabetic patients was detected primarily in alphabetaTCR+CD40 (show CD40 Antibodies)+ lymphocytes.

  9. Bidirectional activity of the NWC promoter is responsible for RAG-2 (show RAG2 Antibodies) transcription in non-lymphoid cells [NWC]

  10. This study reports on the prevalence of RAG1 and RAG2 (show RAG2 Antibodies) mutations in ten severe combined immunodeficiency (show PRKDC Antibodies) disorder patients in Egypt.

Mouse (Murine) Recombination Activating Gene 1 (RAG1) interaction partners

  1. This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (show AKAP17A Antibodies) development to prevent mistimed dsDNA breaks and their deleterious consequences.

  2. a novel RAG1/2-mediated insertion pathway distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares features with reported oncogenic DNA insertions.

  3. loss of the BH3-only (show BBC3 Antibodies) protein BIM (show BCL2L11 Antibodies) accelerated lymphoma development in p53 (show TP53 Antibodies)-deficient mice. This process was negated by concomitant loss of RAG1/2-mediated antigen receptor gene rearrangement.

  4. Nonamer binding domain (NBD) of RAG1 plays a central role in the recognition of recombination signal sequence.

  5. Overall, these findings suggest that the V(D)J recombination-activating gene 1, RAG1, may play a role in long-term memory consolidation.

  6. propose that pre-B cells toggle between pre-BCR (show BCR Antibodies) signals and a RAG1 DNA double-strand break-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain genes

  7. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

  8. The non-core region of RAG1 facilitates chromosomal V(D)J recombination in a ubiquitylation-dependent pathway.

  9. Based on our results, we propose that interaction of RAG2 (show RAG2 Antibodies) with RAG1 induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 interdomain boundary

  10. 12recombination signal sequences-23recombination signal sequences cooperation (the "12/23 rule") is important not only for regulating RAG-mediated DNA cleavage but also for the efficiency of RAG1 and RAG2 (show RAG2 Antibodies) recruitment to chromatin.

Zebrafish Recombination Activating Gene 1 (RAG1) interaction partners

  1. first report of any rag1(-/-) mutant vertebrate mounting a protective secondary immune response to a bacterial pathogen

  2. target-selected inactivation of the rag1 gene

  3. Rag1 has a role in developing zebrafish cortex-medullary regionalization

  4. by embryonic day 4, rag1 transcripts are seen in the pancreas

  5. Recombination signal sequences are recognized by rag1 protein.

  6. Rag1 expression is restricted to a subpopulation of zebrafish olfactory neurons projecting to the lateral olfactory bulb; Rag11 catalytic activity is not essential for axon targeting

  7. This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1 mutants).

RAG1 Antigen Profile

Protein Summary

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.

Gene names and symbols associated with RAG1

  • recombination activating gene 1 (Rag1) antibody
  • recombination activating gene 1 (RAG1) antibody
  • recombination activating gene 1 (rag1) antibody
  • recombinase activating protein (RAG-1) antibody
  • recombination activating gene 1 a (rag1) antibody
  • rag-1 antibody
  • rag1 antibody
  • rag1a antibody
  • RNF74 antibody

Protein level used designations for RAG1

V(D)J recombination-activating protein 1 , recombination activation protein 1 , recombination activating gene 1 , recombination activating protein 1 , recombination-activating gene 1 , recombinase activating protein , V(D)J recombination-activating protein 1-like , RING finger protein 74 , recombinase activating gene 1 , etID309719.25 , recombinase , recombination activating protein

GENE ID SPECIES
84600 Rattus norvegicus
466489 Pan troglodytes
483420 Canis lupus familiaris
506302 Bos taurus
619389 Monodelphis domestica
697322 Macaca mulatta
100049810 Equus caballus
100077097 Ornithorhynchus anatinus
100145555 Xenopus (Silurana) tropicalis
100395720 Callithrix jacchus
100447109 Pongo abelii
100595879 Nomascus leucogenys
397506 Sus scrofa
5896 Homo sapiens
19373 Mus musculus
423164 Gallus gallus
100328950 Oryctolagus cuniculus
30663 Danio rerio
100136833 Oncorhynchus mykiss
100337558 Xenopus laevis
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