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The protein encoded by RAG1 is involved in activation of immunoglobulin V-D-J recombination. Additionally we are shipping RAG1 Kits (25) and RAG1 Proteins (3) and many more products for this protein.
Showing 10 out of 42 products:
Human Monoclonal RAG1 Primary Antibody for WB - ABIN967402
Chun, Schatz, Oettinger, Jaenisch, Baltimore: The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. in Cell 1991
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Human Monoclonal RAG1 Primary Antibody for ELISA, WB - ABIN1098121
Chen, Xiao, Zhang, Li, Liu, Zhao, Ma, Luo, Qiu, Huang, Korteweg, Gu: Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. in PLoS ONE 2011
Show all 2 Pubmed References
Mouse (Murine) Polyclonal RAG1 Primary Antibody for ChIP, WB - ABIN4893588
Zhou, Yu, Chang, Zhang, Zhou, Cammas, Sun: TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells. in Proceedings of the National Academy of Sciences of the United States of America 2012
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Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID (show PRKDC Antibodies)) phenotype similar to that of rodents and humans.
Piglets with biallelic mutations in either RAG1 or RAG2 (show RAG2 Antibodies) exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells.
The show that DNA damage caused by RAG1 activity in pre-B cells was able to downmodulate RAG1 expression and activity, confirming the existence of a negative feedback regulatory mechanism.
Our findings suggest that mutations in RAG1, specifically the p.R474C variant, can be associated with relatively mild clinical symptoms or delayed occurrence of T cell and B cell deficiencies but may predispose to progressive multifocal leukoencephalopathy.
This study compares T-cell development of patients with RAG1-dependent immune deficiencies, and elucidates important differences that help to explain the wide range of immunologic phenotypes that result from different mutations within the same gene of various patients.
Agammaglobulinemia associated to nasal polyposis due to a hypomorphic RAG1 mutation
mutation c.256_257delAA in RAG1 gene seems to occur quite frequently in the Polish patients with severe combined immunodeficiency (show PRKDC Antibodies) and may result in classical OS as well as in severe combined immunodeficiency (show PRKDC Antibodies) without clinical and laboratory features of OS when occurred in homozygous state
study reported 4 patients with RAG1 deficiency: classic severe combined immune deficiency (SCID (show PRKDC Antibodies)) was seen in 2 patients, Omenn syndrome was observed in 1 patient and atypical SCID (show PRKDC Antibodies) was seen in one patient
Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.
These findings provide insight into the role of this poorly understood region of Rag1 and support the role of Rag1 in a post-cleavage stage of recombination
Expression of recombinase RAG-1 in diabetic patients was detected primarily in alphabetaTCR+CD40 (show CD40 Antibodies)+ lymphocytes.
Bidirectional activity of the NWC promoter is responsible for RAG-2 (show RAG2 Antibodies) transcription in non-lymphoid cells [NWC]
This study demonstrated that the lymphocyte-deficient Rag1 animals demonstrated a significantly lower rate of aneurysm formation and rupture.
This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (show AKAP17A Antibodies) development to prevent mistimed dsDNA breaks and their deleterious consequences.
a novel RAG1/2-mediated insertion pathway distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares features with reported oncogenic DNA insertions.
loss of the BH3-only (show BBC3 Antibodies) protein BIM (show BCL2L11 Antibodies) accelerated lymphoma development in p53 (show TP53 Antibodies)-deficient mice. This process was negated by concomitant loss of RAG1/2-mediated antigen receptor gene rearrangement.
Nonamer binding domain (NBD) of RAG1 plays a central role in the recognition of recombination signal sequence.
Overall, these findings suggest that the V(D)J recombination-activating gene 1, RAG1, may play a role in long-term memory consolidation.
propose that pre-B cells toggle between pre-BCR (show BCR Antibodies) signals and a RAG1 DNA double-strand break-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain genes
The non-core region of RAG1 facilitates chromosomal V(D)J recombination in a ubiquitylation-dependent pathway.
Based on our results, we propose that interaction of RAG2 (show RAG2 Antibodies) with RAG1 induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 interdomain boundary
Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations
first report of any rag1(-/-) mutant vertebrate mounting a protective secondary immune response to a bacterial pathogen
target-selected inactivation of the rag1 gene
Rag1 has a role in developing zebrafish cortex-medullary regionalization
by embryonic day 4, rag1 transcripts are seen in the pancreas
Recombination signal sequences are recognized by rag1 protein.
Rag1 expression is restricted to a subpopulation of zebrafish olfactory neurons projecting to the lateral olfactory bulb; Rag11 catalytic activity is not essential for axon targeting
This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1 mutants).
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
V(D)J recombination-activating protein 1
, recombination activation protein 1
, recombination activating gene 1
, recombination activating protein 1
, recombination-activating gene 1
, recombinase activating protein
, V(D)J recombination-activating protein 1-like
, RING finger protein 74
, recombinase activating gene 1
, recombination activating protein