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Regenerating Islet-Derived 3 alpha Proteins (REG3A)

REG3A encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. Additionally we are shipping REG3A Antibodies (89) and REG3A Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
REG3A 5068 Q06141
REG3A 19694 O09037
REG3A 171162 P35231
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Top REG3A Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,326.50
Details

REG3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,

Rat (Rattus) , ,
,

Top referenced REG3A Proteins

  1. Human REG3A Protein expressed in Human Cells - ABIN3216396 : Orelle, Keim, Masciotra, Dagorn, Iovanna: Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. in The Journal of clinical investigation 1993 (PubMed)
    Show all 3 references for ABIN3216396

  2. Rat (Rattus) REG3A Protein expressed in Human Cells - ABIN2009383 : Cavard, Terris, Grimber, Christa, Audard, Radenen-Bussiere, Simon, Renard, Buendia, Perret: Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. in Oncogene 2006 (PubMed)
    Show all 2 references for ABIN2009383

More Proteins for Regenerating Islet-Derived 3 alpha (REG3A) Interaction Partners

Golden Syrian Hamster Regenerating Islet-Derived 3 alpha (REG3A) interaction partners

  1. data suggest that human adult pancreatic ductal cells retain morphogenetic plasticity and demonstrate that a short exposure to INGAP triggers their differentiation into insulin (show INS Proteins)-expressing cells in vitro.

  2. The results indicate that endogenous INGAP plays a "physiological" positive modulatory role in insulin (show INS Proteins) secretion, supporting its possible use in the treatment of prediabetes and Type 2 diabetes.

Human Regenerating Islet-Derived 3 alpha (REG3A) interaction partners

  1. Regulation network analysis confirmed the cell growth related differentially expressed genes, and further uncovered three transcription factor families with immune functions regulated by REG3A

  2. Reg3A overexpression promoted cell growth in pancreatic cancer. SOCS3 (show SOCS3 Proteins) is a key target in cancer by inhibiting cell growth and inducing apoptosis. SOCS3 (show SOCS3 Proteins) negatively regulated Reg3A-mediated cell growth in pancreatic cancer.

  3. Serum regenerating islet-derived 3-alpha is a biomarker of mucosal enteropathies

  4. Both live and heat-inactivated Bifidobacterium breve induced the expression of REGIII-alpha, the human ortholog and homolog of REGIII-gamma (show REG3g Proteins), in human colonic epithelial cells (Caco-2).

  5. Cells transfected with REG III exhibited significantly lower cell proliferation.

  6. human RegIIIalpha (also known as HIP/PAP) binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore

  7. The INGAP-pp may facilitate the differentiation of hUCMSCs into IPCs. However, the IPCs are not as mature as normal human islet beta cells.

  8. Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A (show REG1A Proteins), REG1B (show REG1B Proteins) and REG3A) and enteroendocrine cells (REG4 (show REG4 Proteins)), with a marked expansion of expression during inflammation.

  9. HIP/PAP was abundantly expressed in bladder cancer, and the urinary levels of HIP/PAP could be a novel biomarker for detection of bladder cancer.

  10. REG3A may mediate the epidermal hyperproliferation observed in normal wound repair and in psoriasis.

Mouse (Murine) Regenerating Islet-Derived 3 alpha (REG3A) interaction partners

  1. Data show that regenerating islet-derived 3-alpha (REG3alpha) is a plasma biomarker of gastrointestinal tract graft-versus-host disease that can be combined with clinical stage and histologic grade to improve risk stratification of patients.

  2. Reg2 (show FLOT1 Proteins), Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns.

  3. Reg3alpha stimulates beta-cell replication, by activating Akt (show AKT1 Proteins) kinase and increasing the levels of cyclin D1 (show CCND1 Proteins)/CDK4 (show CDK4 Proteins).

REG3A Protein Profile

Protein Summary

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with REG3A

  • regenerating islet-derived 3 alpha (REG3A)
  • pancreatic beta cell growth factor-like (LOC101829186)
  • regenerating islet-derived 3 alpha (Reg3a)
  • AV063448 protein
  • HIP protein
  • HIP/PAP protein
  • INGAP protein
  • PAP protein
  • PAP-H protein
  • PAP1 protein
  • Pap2 protein
  • PapII protein
  • PBCGF protein
  • PTP protein
  • REG-III protein
  • REG3 protein

Protein level used designations for REG3A

ICRF , PSP , REG , islet cells regeneration factor , islet of Langerhans regenerating protein , lithostathine , pancreatic stone protein , pancreatic thread protein , islet neogenesis associated protein , pancreatic beta cell growth factor , PAP homologous protein , REG-3-alpha , hepatocarcinoma-intestine-pancreas , hepatointestinal pancreatic protein , human proislet peptide , pancreatitis-associated protein 1 , proliferation-inducing protein 34 , proliferation-inducing protein 42 , reg III-alpha , regenerating islet-derived protein 3-alpha , regenerating islet-derived protein III-alpha , RegIII (alpha) , generating islet-derived, mouse homolog 3 alpha , islet of Langerhans regenerating protein 3 , lithostathine 3 , pancreatitis-associated protein 2 , REG 3 , regIII , regenerating islet-derived protein 3 alpha

GENE ID SPECIES
404114 Bos taurus
101829186 Mesocricetus auratus
5068 Homo sapiens
19694 Mus musculus
171162 Rattus norvegicus
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