Regucalcin Proteins (RGN)

The protein encoded by RGN is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. Additionally we are shipping Regucalcin Antibodies (43) and Regucalcin Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RGN 19733 Q64374
RGN 9104 Q15493
RGN 25106 Q03336
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Top Regucalcin Proteins at

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
Yeast Macaca fascicularis His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

RGN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , ,
, ,
Rat (Rattus) ,
, ,

Top referenced Regucalcin Proteins

  1. Human Regucalcin Protein expressed in Escherichia coli (E. coli) - ABIN667537 : Chakraborti, Bahnson: Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions . in Biochemistry 2010 (PubMed)

More Proteins for Regucalcin (RGN) Interaction Partners

Zebrafish Regucalcin (RGN) interaction partners

  1. SMP30/RGN is important for liver proliferation and tumorigenesis.

Mouse (Murine) Regucalcin (RGN) interaction partners

  1. Results suggested that SMP30 deficiency augments myocardial Ischemia/Reperfusion injury through reactive oxygen species generation and attenuation of Akt (show AKT1 Proteins) activation.

  2. This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db (show LEPR Proteins) mice.

  3. SMP30/GNL-positive cells localized around the central veins of livers of mice and decreased numerically with aging. Nuclear SMP30/GNL protein might be a regulatory factor specific for genes whose expression governs transcription and the aging process.

  4. SMP30 may be a potent inhibitory protein against oxidative stress and chronic inflammation.

  5. SMP30 plays an important role in the regulation of coronary vascular tone by myocardium.

  6. These results suggested that SMP30 might be involved in overriding the apoptotic homeostatic mechanism in response to DNA damage.

  7. SMP30 deficiency is closely associated with non-alcoholic fatty liver disease pathogenesis.

  8. left ventricular ejection fraction was more severely reduced in the DOX-treated SMP30 KO mice than in the DOX-treated WT mice, but was preserved in the DOX-treated SMP30 TG mice

  9. Results from using this unique model of AA deficiency, the SMP30/GNL-KO mouse, now provide new information about formerly unknown AA functions that will implement further study of AA in vivo.

  10. SMP30/gluconolactonase mRNA transcripts were detected in the ovaries of mice, and the expression of these transcripts increased from days 0 to 8 of gestation and decreased rapidly thereafter.

Human Regucalcin (RGN) interaction partners

  1. High RGN expression is associated with hepatocellular carcinoma.

  2. the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 (show TP53 Proteins) and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome.

  3. Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways.

  4. Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase (show GLB1 Proteins) expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis.

  5. data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells.

  6. immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients

  7. results highlighted the importance of RGN as a regulatory protein in Ca2 (show CA2 Proteins)+-dependent signaling pathways and its deregulation of RGN expression by Ca2 (show CA2 Proteins)+o may contribute for onset and progression of PCa (show FLVCR1 Proteins).

  8. This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review]

  9. The alternatively spliced variants of the regucalcin gene were found to be expressed in various human normal and tumor tissues.

  10. RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland.

Cow (Bovine) Regucalcin (RGN) interaction partners

  1. estrogen administration down-regulated RGN gene expression in the accessory sex glands of veal calves and beef cattle, while androgen treatment reduced RGN gene expression only in the testis.

Regucalcin (RGN) Protein Profile

Protein Summary

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.

Gene names and symbols associated with Regucalcin Proteins (RGN)

  • CG1803 gene product from transcript CG1803-RA (regucalcin)
  • regucalcin (rgn)
  • regucalcin (senescence marker protein-30) (rgn)
  • regucalcin (senescence marker protein-30) (RGN)
  • DyakGE16489-PA (Dyakregucalcin)
  • regucalcin (Rgn)
  • regucalcin (RGN)
  • regucalcin (senescence marker protein-30) (Rgn)
  • AI265316 protein
  • CG1803 protein
  • Dmel\\CG1803 protein
  • DyakGE16489 protein
  • dyak_GLEANR_17905 protein
  • GE16489 protein
  • GNL protein
  • Rc protein
  • Reguc protein
  • regucalcin protein
  • rgn-A protein
  • SMP-30 protein
  • SMP30 protein
  • T1 protein
  • xsmp-30 protein
  • xsmp30 protein
  • zgc:92078 protein

Protein level used designations for Regucalcin Proteins (RGN)

CG1803-PA , CG1803-PB , CG1803-PC , CG1803-PD , regucalcin-PA , regucalcin-PB , regucalcin-PC , regucalcin-PD , RC , gluconolactonase , regucalcin , regucalcin (senescence marker protein-30) , DyakGE16489-PA , Dyakregucalcin-PA , GE16489-PA , SMP-30 , senescence marker protein 30 , senescence marker protein-30 , xSMP-30

32165 Drosophila melanogaster
403070 Danio rerio
448549 Xenopus (Silurana) tropicalis
465598 Pan troglodytes
480893 Canis lupus familiaris
6523987 Drosophila yakuba
100060684 Equus caballus
100171395 Ovis aries
100174578 Pongo abelii
100196365 Salmo salar
100528098 Ictalurus punctatus
19733 Mus musculus
9104 Homo sapiens
395480 Gallus gallus
373659 Xenopus laevis
25106 Rattus norvegicus
768107 Sus scrofa
280910 Bos taurus
100008619 Oryctolagus cuniculus
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