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Ribonuclease H2, Subunit B Proteins (RNASEH2B)

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. Additionally we are shipping Ribonuclease H2, Subunit B Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNASEH2B 79621 Q5TBB1
RNASEH2B 67153 Q80ZV0
Rat RNASEH2B RNASEH2B 361056 Q5XI96
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Top Ribonuclease H2, Subunit B Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,821.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RNASEH2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Ribonuclease H2, Subunit B (RNASEH2B) Interaction Partners

Human Ribonuclease H2, Subunit B (RNASEH2B) interaction partners

  1. Aicardi-Goutieres syndrome 2 is caused by mutations in the ribonuclease H2 subunit B gene RNASEH2B.

  2. RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner.

  3. A genome-wide search for homozygosity in Aicardi-Goutieres syndrome patients in the Faroe Islands revealed one single 15.6 Mb region of homozygosity on chromosome 13, which included RNASEH2B, where a splice site mutation c.322-3C>G was identified.

  4. This study demonistrated that ribonuclease H2 mutation releated to Aicardi-Goutieres syndrome.

  5. Congenital infection is seen with preserved neurological function, most frequently due to RNASEH2B mutations.

  6. Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the B subunit of RNase H2.

Mouse (Murine) Ribonuclease H2, Subunit B (RNASEH2B) interaction partners

  1. Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response

  2. Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review]

  3. Study performed targeted mutagenesis of the mouse Rnaseh2b gene to gain insight into the in vivo role of the mammalian RNase H2 enzyme. Ablation of Rnaseh2b in mice leads to early embryonic lethality due to elevated DNA damage and reduced cellular proliferation during gastrulation.

  4. Data show that the interwoven architecture of RNase H2B and RNase H2C (show RNASEH2C Proteins) that interface with RNase H2A (show RNASEH2A Proteins) in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs.

Ribonuclease H2, Subunit B (RNASEH2B) Protein Profile

Protein Summary

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).

Gene names and symbols associated with RNASEH2B

  • ribonuclease H2, subunit B (RNASEH2B)
  • ribonuclease H2, subunit B (Rnaseh2b)
  • ribonuclease H2, subunit B (rnaseh2b)
  • 1110019N06Rik protein
  • 2610207P08Rik protein
  • AGS2 protein
  • Dleu8 protein

Protein level used designations for RNASEH2B

Aicardi-Goutieres syndrome 2 protein , RNase H2 subunit B , deleted in lymphocytic leukemia 8 , ribonuclease H2 subunit B , ribonuclease HI subunit B , deleted in lymphocytic leukemia 8 homolog

GENE ID SPECIES
79621 Homo sapiens
67153 Mus musculus
361056 Rattus norvegicus
509258 Bos taurus
496343 Xenopus laevis
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