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RRM1 encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Additionally we are shipping Ribonucleotide Reductase M1 Kits (10) and Ribonucleotide Reductase M1 Proteins (8) and many more products for this protein.
Showing 10 out of 116 products:
Chicken Polyclonal RRM1 Primary Antibody for WB - ABIN2782438
Inglis: Requirement of arginine for the replication of herpes virus. in The Journal of general virology 1970
Show all 4 references for ABIN2782438
Human Polyclonal RRM1 Primary Antibody for WB - ABIN1881767
Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. in Molecular human reproduction 2010
Show all 2 references for ABIN1881767
Human Monoclonal RRM1 Primary Antibody for FACS, IHC (p) - ABIN1687336
Ulker, Duman, Sahin, Gumurdulu: ERCC1 and RRM1 as a predictive parameter for non-small cell lung, ovarian or pancreas cancer treated with cisplatin and/or gemcitabine. in Contemporary oncology (Poznań, Poland) 2015
A significant association has been found between RRM1 rs12806698 (-269C>A) RRM1 genotype and the risk for developing non-small cell lung cancer.
Results underline the relevance of microRNA-101-3p-driven regulation of RRM1 in pancreatic ductal carcinoma gemcitabine resistance.
TUBB3 (show TUBB3 Antibodies), TOP2A (show TOP2A Antibodies), CYP19A1 (show CYP19A1 Antibodies) and CYP2D6 (show CYP2D6 Antibodies) gene expression, but not protein expression, was associated with patient survival.
A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported.
RRM1 expression was predictive and prognostic of clinical outcome in advanced UC treated with gemcitabine plus platinum combination chemotherapy
RNA expression of deoxycytidine kinase (DCK (show DCK Antibodies)), human equilibrative nucleoside transporter-1 (ENT1 (show SLC29A1 Antibodies)) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA (show CDA Antibodies)) was significantly lower in ex vivo Ara (show FOXC1 Antibodies)-C sensitive samples.
Bmi1 (show BMI1 Antibodies) and possibly RNF2 (show RNF2 Antibodies) may be attractive biomarkers of gemcitabine resistance in the context of RRM1 expression.
For RRM1 C37A-T524C genotype, sensitive group had higher proportion of high effective genotype than non-sensitive group (p=0.009).
Adenoviral vector expressing short hairpin RNA targeting RRM1 exerts potent antitumor effects and increases sensitivity to gemcitabine.
we propose that RRM1 protein can inhibit CRC (show CALR Antibodies) invasion and metastasis at the advanced stage by regulating PTEN (show PTEN Antibodies) transactivation and its downstream pathways in addition to forming an RR holoenzyme for supporting cancer proliferation.
This work reveals that binding of RRM1 to RRM2 (show RRM2 Antibodies) is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 (show RRM2 Antibodies) improves cardiac performance
silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance.
Tip60 (show KAT5 Antibodies)-dependent recruitment of RNR (show REN1 Antibodies) plays an essential role in dNTP supply for DNA repair
The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1 (show MR1 Antibodies)(6) predominates over the dimer form mR1 (show MR1 Antibodies)(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located.
overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model.
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.
ribonucleoside diphosphate reductase large subunit
, ribonucleoside diphosphate reductase M1 subunit
, ribonucleoside-diphosphate reductase large subunit
, ribonucleoside-diphosphate reductase M1 chain
, ribonucleotide reductase M1 polypeptide
, ribonucleotide reductase M1
, ribonucleoside-diphosphate reductase large subunit-like
, ribonucleoside-diphosphate reductase subunit M1
, ribonucleotide reductase, R1 subunit
, ribonucleotide reductase large subunit
, ribonucleotide reductase protein r1 class I