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anti-Ribonucleotide Reductase M1 (RRM1) Antibodies

RRM1 encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Additionally we are shipping Ribonucleotide Reductase M1 Kits (10) and Ribonucleotide Reductase M1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RRM1 6240 P23921
RRM1 20133 P07742
RRM1 685579  
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Top anti-Ribonucleotide Reductase M1 Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RRM1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Caenorhabditis elegans Rabbit Un-conjugated WB WB Suggested Anti-RRM1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated FACS, IHC (p) Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody in HeLa (green) compare to negative control of rabbit IgG (blue). 1 mL Log in to see 2 to 3 Days
$648.00
Details
Human Rabbit Un-conjugated WB RRM1 Antibody (N-term) (ABIN1881767) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the RRM1 antibody detected the RRM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) Flow cytometric analysis of rabbit anti-RRM1 (SP167) antibody in HeLa (green) compare to negative control of rabbit IgG (blue). 7 mL Log in to see 2 to 3 Days
$367.00
Details
Human Rabbit Un-conjugated FACS, IHC (p) 1 mL Log in to see 6 to 8 Days
$797.50
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$237.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$507.83
Details

RRM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Ribonucleotide Reductase M1 Antibodies

  1. Chicken Polyclonal RRM1 Primary Antibody for WB - ABIN2782438 : Inglis: Requirement of arginine for the replication of herpes virus. in The Journal of general virology 1970 (PubMed)
    Show all 4 references for ABIN2782438

  2. Human Polyclonal RRM1 Primary Antibody for WB - ABIN1881767 : Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. in Molecular human reproduction 2010 (PubMed)
    Show all 2 references for ABIN1881767

  3. Human Monoclonal RRM1 Primary Antibody for FACS, IHC (p) - ABIN1687336 : Ulker, Duman, Sahin, Gumurdulu: ERCC1 and RRM1 as a predictive parameter for non-small cell lung, ovarian or pancreas cancer treated with cisplatin and/or gemcitabine. in Contemporary oncology (Poznań, Poland) 2015 (PubMed)

More Antibodies against Ribonucleotide Reductase M1 Interaction Partners

Human Ribonucleotide Reductase M1 (RRM1) interaction partners

  1. A significant association has been found between RRM1 rs12806698 (-269C>A) RRM1 genotype and the risk for developing non-small cell lung cancer.

  2. Results underline the relevance of microRNA-101-3p-driven regulation of RRM1 in pancreatic ductal carcinoma gemcitabine resistance.

  3. TUBB3 (show TUBB3 Antibodies), TOP2A (show TOP2A Antibodies), CYP19A1 (show CYP19A1 Antibodies) and CYP2D6 (show CYP2D6 Antibodies) gene expression, but not protein expression, was associated with patient survival.

  4. A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported.

  5. RRM1 expression was predictive and prognostic of clinical outcome in advanced UC treated with gemcitabine plus platinum combination chemotherapy

  6. RNA expression of deoxycytidine kinase (DCK (show DCK Antibodies)), human equilibrative nucleoside transporter-1 (ENT1 (show SLC29A1 Antibodies)) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA (show CDA Antibodies)) was significantly lower in ex vivo Ara (show FOXC1 Antibodies)-C sensitive samples.

  7. Bmi1 (show BMI1 Antibodies) and possibly RNF2 (show RNF2 Antibodies) may be attractive biomarkers of gemcitabine resistance in the context of RRM1 expression.

  8. For RRM1 C37A-T524C genotype, sensitive group had higher proportion of high effective genotype than non-sensitive group (p=0.009).

  9. Adenoviral vector expressing short hairpin RNA targeting RRM1 exerts potent antitumor effects and increases sensitivity to gemcitabine.

  10. we propose that RRM1 protein can inhibit CRC (show CALR Antibodies) invasion and metastasis at the advanced stage by regulating PTEN (show PTEN Antibodies) transactivation and its downstream pathways in addition to forming an RR holoenzyme for supporting cancer proliferation.

Mouse (Murine) Ribonucleotide Reductase M1 (RRM1) interaction partners

  1. This work reveals that binding of RRM1 to RRM2 (show RRM2 Antibodies) is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.

  2. analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 (show RRM2 Antibodies) improves cardiac performance

  3. silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance.

  4. Tip60 (show KAT5 Antibodies)-dependent recruitment of RNR (show REN1 Antibodies) plays an essential role in dNTP supply for DNA repair

  5. The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1 (show MR1 Antibodies)(6) predominates over the dimer form mR1 (show MR1 Antibodies)(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located.

  6. overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model.

Ribonucleotide Reductase M1 (RRM1) Antigen Profile

Protein Summary

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Gene names and symbols associated with RRM1

  • ribonucleotide reductase M1 (RRM1) antibody
  • Ribonucleoside diphosphate reductase large subunit (RnrL) antibody
  • ribonucleotide reductase M1 (rrm1) antibody
  • ribonucleotide reductase M1 (Rrm1) antibody
  • ribonucleotide reductase M1 polypeptide (rrm1) antibody
  • cb396 antibody
  • cb838 antibody
  • CG5371 antibody
  • CHUNP6866 antibody
  • Dmel\\CG5371 antibody
  • DmRNR1 antibody
  • l(2)k06709 antibody
  • r1 antibody
  • RIR1 antibody
  • RNR1 antibody
  • RnrM1 antibody
  • RntL antibody
  • RR1 antibody
  • sb:cb548 antibody
  • wu:fb39b07 antibody
  • wu:fi14b02 antibody
  • wu:fk95f07 antibody
  • XRRM1 antibody

Protein level used designations for RRM1

ribonucleoside diphosphate reductase large subunit , CG5371-PA , RnrL-PA , ribonucleoside diphosphate reductase M1 subunit , ribonucleoside-diphosphate reductase large subunit , ribonucleoside-diphosphate reductase M1 chain , ribonucleotide reductase M1 polypeptide , ribonucleotide reductase M1 , ribonucleoside-diphosphate reductase large subunit-like , ribonucleoside-diphosphate reductase subunit M1 , ribonucleotide reductase, R1 subunit , ribonucleotide reductase large subunit , ribonucleotide reductase protein r1 class I

GENE ID SPECIES
100053126 Equus caballus
34392 Drosophila melanogaster
450974 Pan troglodytes
717990 Macaca mulatta
100472317 Ailuropoda melanoleuca
100562780 Anolis carolinensis
100599741 Nomascus leucogenys
399431 Xenopus laevis
419081 Gallus gallus
6240 Homo sapiens
476823 Canis lupus familiaris
505537 Bos taurus
20133 Mus musculus
685579 Rattus norvegicus
100525117 Sus scrofa
100172956 Pongo abelii
30740 Danio rerio
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