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Ring Finger and CCCH-Type Domains 1 Proteins (RC3H1)

RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). Additionally we are shipping RC3H1 Antibodies (26) and RC3H1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat RC3H1 RC3H1 680586  
RC3H1 381305 Q4VGL6
RC3H1 149041 Q5TC82
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Top RC3H1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RC3H1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Ring Finger and CCCH-Type Domains 1 (RC3H1) Interaction Partners

Mouse (Murine) Ring Finger and CCCH-Type Domains 1 (RC3H1) interaction partners

  1. The authors unexpectedly uncover a ROQUIN-AMPK (show PRKAA1 Proteins) metabolic signaling nexus essential for selectively promoting T follicular helper cell responses.

  2. Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes.

  3. Roquin also directly binds Argonaute2 (show EIF2C2 Proteins), a central component of the RNA-induced silencing complex, and miR (show MLXIP Proteins)-146a, a microRNA that targets Icos (show ICOS Proteins) mRNA.

  4. small intestinal inflammation in Rc3h1(san/san) and Rc3h1(gt/gt (show FABP6 Proteins)) mice is due to a failure of Roquin expression in the immune system and not to insufficient systemic Roquin expression.

  5. Over-expression of Roquin exacerbates T-cell mediated hepatitis.

  6. Roquin inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6 (show IL6 Proteins), ICOS (show ICOS Proteins), c-Rel (show NFkBP65 Proteins), IRF4 (show IRF4 Proteins), IkappaBNS (show NFKBID Proteins) and IkappaBzeta (show NFKBIZ Proteins).

  7. Results show an opposing relationship between Roquin-1 and the IL-17a (show IL17A Proteins) proinflammatory cytokine. Enforced expression of Rc3h1 restricts Il17a (show IL17A Proteins) expression, and exposure of T cells to IL-10 (show IL10 Proteins) increases Rc3h1 expression.

  8. Roquin makes mainly non-sequence-specific contacts to the RNA, binding a more relaxed constitutive decay element consensus sequence than previously thought.

  9. Study shows that neither alteration of ROQUIN gene nor deregulation of miR101 expression is likely to be a frequent recurrent event in AITL.

  10. Extensive cytokine dysregulation resulting in both over-expression and under-expression of chemotactic cytokines occurred in the ileum of Roquin(san/san) mice, the region most prone to the development of inflammation

Human Ring Finger and CCCH-Type Domains 1 (RC3H1) interaction partners

  1. Crystal structures, small-angle X-ray scattering, and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are different in their structures and functions.

  2. A distinct, sequence-induced conformation is required for recognition of the constitutive decay element RNA by Roquin.

  3. Roquin-1 and roquin-2 proteins function redundantly in mRNA degradation.

  4. RC3H1 binds preferentially short-lived and DNA damage-induced mRNAs. Knockdown of RC3H1 resulted in increased A20 (show TNFAIP3 Proteins) protein expression, thereby interfering with IkappaB kinase (show CHUK Proteins) and NF-kappaB (show NFKB1 Proteins) activities.

  5. In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline (show ZFP36 Proteins), Roquins, and Regnase-1.

  6. Roquin binding to target mRNAs involves a winged helix-turn-helix motif.

  7. Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin depends on their translation status and enables elaborate control of inflammation.

  8. Roquin-mediated degradation of HMGXB3 (show HMGXB3 Proteins) and IL6 (show IL6 Proteins) mRNAs in human cells, demonstrates the importance of both binding sites for mRNA decay.

  9. Excessive interferon (IFN)-gamma (show IFNA Proteins) signaling promotes accumulation of Roquin-mutated, short-lived effector-like CD8 (show CD8A Proteins)+ T cells in autoimmune-prone transgenic mice.

RC3H1 Protein Profile

Protein Summary

RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005

Gene names and symbols associated with RC3H1

  • ring finger and CCCH-type domains 1 (Rc3h1)
  • ring finger and CCCH-type zinc finger domains 1 (Rc3h1)
  • ring finger and CCCH-type zinc finger domains 1 (RC3H1)
  • ring finger and CCCH-type domains 1 (RC3H1)
  • ring finger and CCCH-type zinc finger domains 1 (rc3h1)
  • RING CCCH (C3H) domains 1 (Rc3h1)
  • 5730557L09Rik protein
  • Gm551 protein
  • mKIAA2025 protein
  • N28103 protein
  • RC3H1 protein
  • RGD1563512 protein
  • RNF198 protein
  • ROQUIN protein
  • si:dkey-192m14.4 protein

Protein level used designations for RC3H1

RING CCCH (C3H) domains 1 , ring finger and CCCH-type zinc finger domains 1 , roquin , roquin-like , ring finger and CCCH-type domains 1 , RING finger and C3H zinc finger protein 1 , probable E3 ubiquitin-protein ligase Roquin , protein Sanroque , RING finger protein 198

GENE ID SPECIES
680586 Rattus norvegicus
304916 Rattus norvegicus
424439 Gallus gallus
457530 Pan troglodytes
480065 Canis lupus familiaris
568568 Danio rerio
707745 Macaca mulatta
789395 Bos taurus
100400000 Callithrix jacchus
100459202 Pongo abelii
100470504 Ailuropoda melanoleuca
381305 Mus musculus
149041 Homo sapiens
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