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Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) Proteins (ROBO3)

ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. Additionally we are shipping ROBO3 Antibodies (84) and ROBO3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ROBO3 19649  
Rat ROBO3 ROBO3 315564  
ROBO3 64221 Q96MS0
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Top ROBO3 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

ROBO3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
, ,

More Proteins for Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) Interaction Partners

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. This study show that this commissural neuron population includes spinal inhibitory neurons and sensory nociceptors and show that this population depends on Robo/Slit signaling yet crosses the dorsal midline in a Robo3-independent manner.

  2. These findings identify NELL2 (show NELL2 Proteins) as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 (show NELL2 Proteins) repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.

  3. results suggest that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor for Slit repulsion into one that both silences Slit repulsion and potentiates Netrin attraction

  4. this study demonistrated that Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.

  5. Rerouting climbing fibers to an ipsilateral projection reversed complex-spike modulation. Ptf1a (show PTF1A Proteins)::cre;Robo3(lox/lox (show LOX Proteins)) mice showed severe ataxia (show USP14 Proteins) indicating the impact of climbing fi ber input on reciprocity of Purkinje cell fi ring during motor coordination.

  6. Posttranscriptional regulation of Robo3 mediated by Musashi-1 (show MSI1 Proteins) controls midline crossing of precerebellar neurons.

  7. Pax-2 (show PAX2 Proteins)/RB binding reverses repression of Rig-1 protein.

  8. The Slit receptors Robo2 (show ROBO2 Proteins) and Robo3/Rig-1 are expressed in the subventricular zone and the rostral migratory stream and Slit1 (show SLIT1 Proteins) and Slit2 (show SLIT2 Proteins) are present in the adult septum and are responsible for both the septum and the CP repulsive activity in vitro

  9. Expression of Rig-1 protein by commissural axons is inversely correlated with Slit sensitivity. Removal of Rig-1 results in a total failure of commissural axons to cross.

  10. two functionally antagonistic isoforms of Robo3 with distinct carboxy termini arising from alternative splicing have been found

Human Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. confirmed that ROBO3 increases with clinical grade and miR (show MLXIP Proteins)-383 expression is inversely correlated to that of ROBO3

  2. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330

  3. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations).

  4. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1 (show ROBO1 Proteins)/2 into a late endosome- and lysosome-dependent degradation pathway.

  5. The novel ROBO3 mutation in this family may be among the most deleterious

  6. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations

  7. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis.

  8. RIG-I (show DDX58 Proteins) or melanoma differentiation-associated gene (MDA)5 (show IFIH1 Proteins) signaling through mitochondrial antiviral signaling protein MAVS (show MAVS Proteins) is required for activation of interferon (show IFNA Proteins) (IFN)-beta (show IFNB1 Proteins) production by rotavirus-infected intestinal epithelial cells.

  9. Slit3 (show SLIT1 Proteins) inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis.

  10. mutations in the ROBO3 gene, which shares homology with roundabout (show ROBO1 Proteins) genes important in axon guidance in developing Drosophila, zebrafish, and mouse.

ROBO3 Protein Profile

Protein Summary

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Gene names and symbols associated with ROBO3

  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (ROBO3)
  • roundabout, axon guidance receptor, homolog 3 (LOC515936)
  • roundabout homolog 3 (Drosophila) (Robo3)
  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (Robo3)
  • HGPPS protein
  • HGPS protein
  • RBIG1 protein
  • Rig-1 protein
  • RIG1 protein
  • Robo3a protein
  • Robo3b protein

Protein level used designations for ROBO3

retinoblastoma inhibiting gene 1 , retinoblastoma-inhibiting gene 1 protein , roundabout homolog 3 , roundabout, axon guidance receptor, homolog 3 , roundabout-like protein 3

GENE ID SPECIES
100072287 Equus caballus
515936 Bos taurus
19649 Mus musculus
315564 Rattus norvegicus
64221 Homo sapiens
489307 Canis lupus familiaris
100858578 Gallus gallus
100524637 Sus scrofa
100337359 Bos taurus
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