Runt-Related Transcription Factor 1 (RUNX1) ELISA Kits

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (285) and RUNX1 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 ELISA Kits at antibodies-online.com

Showing 6 out of 17 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
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$480.00
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Human
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$898.33
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Human
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More ELISA Kits for RUNX1 Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

  2. Study reveals a previously unrecognized synergism between ETV6 (show ETV6 ELISA Kits)/RUNX1 and BCL2 (show BCL2 ELISA Kits) impacting on malignant disease and autoimmunity.

  3. Data provide evidence that Runx1 plays a role in regulating the sphingolipid rheostat in normal development and that perturbation of this cell fate regulator contributes to Runx-driven lymphomagenesis.

  4. The findings suggest that the absence of uPA (show PLAU ELISA Kits) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  5. Flt3 and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult but not fetal stages of murine development.

  6. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (show AQP5 ELISA Kits) protein of the acinar cells in the SMG (show SNRPG ELISA Kits) in order to allow for the proper secretion of saliva (show RAG1AP1 ELISA Kits)

  7. High RUNX1 expression is associated with skin squamous cell carcinoma.

  8. deficiency alters the expression of a crucial subset of TAL1 (show TAL1 ELISA Kits)- and NOTCH1 (show NOTCH1 ELISA Kits)-regulated genes, including the MYB (show MYB ELISA Kits) and MYC (show MYC ELISA Kits) oncogenes, respectively.

  9. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  10. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. We observed a strong correlation between EVI1 (show MECOM ELISA Kits) and alpha1, 6-fucosyltransferase (FUT8 (show FUT8 ELISA Kits)) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease.

  2. A novel function of RUNX1 and offer an explanation for the link between RUNX1 mutations and chemotherapy and radiation resistance. Moreover, these data suggest that pharmacologic modulation of RUNX1 might be an attractive new approach to treat hematologic malignancies.

  3. high EVI1 (show MECOM ELISA Kits) expression might predict high risk of relapse in AML patients undergoing myeloablative allo-HSCT in CR1 (show CR1 ELISA Kits).

  4. Hypermethylation of the CTNNA1 (show CTNNA1 ELISA Kits) promoter was associated with unfavorable karyotype, and possessed the higher frequency of coexisting with ASXL1 (show ASXL1 ELISA Kits) and RUNX1 mutations.

  5. Three siblings with germline causative RUNX1 variant, developed acute myelomonocytic leukemia and acquired variants within the JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits) pathway, specifically targeting JAK2 (show JAK2 ELISA Kits) and SH2B3 (show SH2B3 ELISA Kits).

  6. These findings suggest RUNX1high is a prognostic biomarker of unfavorable outcome in cytogenetically normal acute myeloid leukemia (show BCL11A ELISA Kits)

  7. 3 di ff erent heterozygous mutations segregated with thrombocytopenia in 3 families: one missense (c.578T > A/p.Ile193Asn) variant a ff ecting a well conserved residue of the runt-homologous domain, 2 nucleotide substitutions of the canonical "gt" dinucleotide in the donor splice sites of intron 4, (c.351 1 1G > A) and intron 8 (c.967 1 2_5del), and 2 alternative spliced products affecting the transactivation domain.

  8. Here, we report the first identification of H3(K27M) and H3(K27I) mutations in patients with AML. We find that these lesions are major determinants of reduced H3K27me2/3 in these patients and that they are associated with common aberrations in the RUNX1 gene.

  9. NPM1 (show NPM1 ELISA Kits) mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia (show BCL11A ELISA Kits) lacking recurrent cytogenetic abnormalities

  10. phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF ELISA Kits) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 ELISA Kits) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 ELISA Kits), or cohesin subunit Smc3 (show SMC3 ELISA Kits), fail to express runx3 (show RUNX3 ELISA Kits) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 ELISA Kits) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen Profile

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981) antibody
  • runt-related transcription factor (runt) antibody
  • runt related transcription factor 1 (Runx1) antibody
  • runt related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor 1 (runx1) antibody
  • runt related transcription factor 1 L homeolog (runx1.L) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor 1 (Runx1) antibody
  • AI462102 antibody
  • aml antibody
  • aml-1 antibody
  • Aml1 antibody
  • aml1-evi-1 antibody
  • amlcr1 antibody
  • cbfa2 antibody
  • evi-1 antibody
  • Pebp2a2 antibody
  • pebp2ab antibody
  • Pebpa2b antibody
  • Runx-1 antibody
  • runx1 antibody
  • runxa antibody
  • XAML antibody
  • Xaml1 antibody

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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