Runt-Related Transcription Factor 3 (RUNX3) ELISA Kits

RUNX3 encodes a member of the runt domain-containing family of transcription factors. Additionally we are shipping RUNX3 Antibodies (218) and RUNX3 Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
RUNX3 12399  
RUNX3 864 Q13761
RUNX3 156726  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.054 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
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More ELISA Kits for RUNX3 Interaction Partners

Zebrafish Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta (show CBFB ELISA Kits) is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta (show CBFB ELISA Kits), demonstrating that Cbfbeta (show CBFB ELISA Kits) in this context serves solely as a signal amplifier of Runx3 activity.

  2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  3. Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1 (show RUNX1 ELISA Kits)-expressing cells in the ventral wall of the dorsal aorta.

  4. Zebrafish embryos lacking Rad21 (show RAD21 ELISA Kits), or cohesin subunit Smc3 (show SMC3 ELISA Kits), fail to express runx3 and lose hematopoietic runx1 (show RUNX1 ELISA Kits) expression in early embryonic development.

Pig (Porcine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. These results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.

Mouse (Murine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. The findings suggest that the absence of uPA (show PLAU ELISA Kits) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  2. Runx3-deficient CD8 (show CD8A ELISA Kits)(+) cytotoxic effector T cells aberrantly upregulated genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6 (show BCL6 ELISA Kits), Tcf7 (show TCF7 ELISA Kits) and Cxcr5 (show CXCR5 ELISA Kits). Mechanistically, the Runx3-CBFbeta (show CBFB ELISA Kits) transcription factor complex deployed H3K27me3 to Bcl6 (show BCL6 ELISA Kits) and Tcf7 (show TCF7 ELISA Kits) genes to suppress the TFH program.

  3. Deletion of Runx3 in the peripheral nervous system or specifically in peripheral sensory neurons, or of enhancer elements driving Runx3 expression in proprioceptive neurons, induced prepubertal scoliosis.

  4. We found that Runx3 exerted a positive effect on early myeloid development

  5. Runx3 plays a crucial role in the hypothalamo-pituitary-gonadal axis

  6. intricate combinatorial interplay among the three regulatory elements governs Runx3 expression in distinct subtypes of TrkC (show NTRK3 ELISA Kits) neurons while concomitantly extinguishing its expression in non-TrkC (show NTRK3 ELISA Kits) neurons

  7. this study identifies a compensatory signaling mechanism that prevents lineage-fate errors by dynamically modulating Runx3d induction rates during MHC I positive selection

  8. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 (show NTRK3 ELISA Kits) variants

  9. Runx3 is crucial for the phenotypic and functional changes observed in ThPok (show ZBTB7B ELISA Kits)-deficient invariant natural killer T cells.

  10. the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa

Human Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. Loss of RUNX3 expression strongly correlated with adverse prognosis, independent of subtype. Further studies are warranted to elucidate the biology and prognostic utility of RUNX3 in DLBCL.

  2. Runx3 plays a critical role in R-point regulation and defense against cellular transformation.

  3. RUNX3 mRNA and protein expression were upregulated in nasal-type extranodal NK/T-cell lymphoma (NKTL) patient samples and NKTL cell lines compared to normal NK cells. RUNX3 silenced NKTL cells showed increased apoptosis and reduced cell proliferation. MYC (show MYC ELISA Kits) and RUNX3 binding occurs. Potential binding sites for MYC (show MYC ELISA Kits) were identified in the RUNX3 enhancer region.

  4. The methylation status of Runx3 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer.

  5. RUNX 3 hypermethylation is associated with breast cancer.

  6. High RUNX3 expression is associated with gastric cancer.

  7. we present evidence that RUNX3 can act as a tumor suppressor in a human T-cell malignancy and suggest that this effect is predominantly mediated through transcripts from its distal promoter, in particular RUNX3/p46 (show POLDIP3 ELISA Kits).

  8. Our results from clinical samples also suggest that Threonine 209 phosphorylation by Pak1 (show PAK1 ELISA Kits) could be a potential therapeutic target and of great clinical relevance with implications for Runx3 inactivation in cancer cells where Runx3 is known to be oncogenic. The findings presented in this study provide evidence of Runx3-Threonine 209 phosphorylation as a molecular switch in dictating the tissue-specific dualistic functions

  9. RUNX3 acts as a tumour suppressor

  10. MicroRNA-145 could regulate the balance of Th1 (show TH1L ELISA Kits)/Th2 through targeting the RUNX3 in asthma patients.

RUNX3 Antigen Profile

Antigen Summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX3

  • runt-related transcription factor 3 (runx3) antibody
  • runt-related transcription factor 3 (RUNX3) antibody
  • runt related transcription factor 3 (RUNX3) antibody
  • runt related transcription factor 3 (runx3) antibody
  • runt related transcription factor 3 L homeolog (runx3.L) antibody
  • runt related transcription factor 3 (Runx3) antibody
  • runt-related transcription factor 3 (Runx3) antibody
  • AML2 antibody
  • Cbfa3 antibody
  • frrunx3 antibody
  • Pebp2a3 antibody
  • PEBP2aC antibody
  • runx3 antibody
  • runxb antibody

Protein level used designations for RUNX3

runt-related transcription factor b , runt-related transcription factor 3 , core-binding factor 3 , frRunx3/p45 , CBF-alpha-3 , PEA2-alpha C , PEBP2-alpha C , SL3-3 enhancer factor 1 alpha C subunit , SL3/AKV core-binding factor alpha C subunit , acute myeloid leukemia 2 protein , core binding factor alpha 3 , core-binding factor subunit alpha-3 , oncogene AML-2 , polyomavirus enhancer-binding protein 2 alpha C subunit , runt domain, alpha subunit 3 , transcription factor AML2/CBFA3 , PEA2 alpha C , PEBP2 alpha C , acute myeloid leukemia gene 2 , core-binding factor, runt domain, alpha subunit 3 , transcription factor AML2 , Runt related transcription factor 3 , Runx3 MASN-variant

58127 Danio rerio
403159 Sus scrofa
456633 Pan troglodytes
100049632 Takifugu rubripes
100474431 Ailuropoda melanoleuca
100500732 Xenopus laevis
12399 Mus musculus
864 Homo sapiens
617389 Bos taurus
156726 Rattus norvegicus
769687 Gallus gallus
487366 Canis lupus familiaris
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