Runt-Related Transcription Factor 2 Proteins (RUNX2)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Antibodies (237) and RUNX2 Kits (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX2 12393 Q08775
RUNX2 860 Q13950
RUNX2 367218  
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Top RUNX2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$746.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
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Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$2,271.50
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,541.00
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$948.75
Details

RUNX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
,
Rat (Rattus)

More Proteins for Runt-Related Transcription Factor 2 (RUNX2) Interaction Partners

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. SIRT1 (show SIRT1 Proteins) interacts with and promotes the transactivation potential of RUNX2.

  2. ABL (show ABL1 Proteins) potentiated the assembly and activation of the RUNX2-TAZ (show TAZ Proteins) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Proteins)-mediated adipogenesis.

  3. urther investigation indicated that p205 (show GNB2L1 Proteins) may disturb the formation of Runx2/Ids (show IDS Proteins) complex and free more Runx2 to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 (show GNB2L1 Proteins) functions as an activator in osteoblast differentiation.

  4. identified a novel genomic region in which DNA methylation (show HELLS Proteins) status is related to Runx2 expression and detected demethylation of Runx2-DMR (show WDR20 Proteins) during osteoblastic differentiation in mouse and dog.

  5. overexpression of Fam3c (show FAM3C Proteins) caused reduction of Runx2 expression at both mRNA and protein levels. Fam3c (show FAM3C Proteins) was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c (show FAM3C Proteins) and TGF-beta1 (show TGFB1 Proteins) were found to regulate each other reciprocally

  6. MAP kinase (show MAPK1 Proteins)-dependent RUNX2 phosphorylation Is necessary for epigenetic modification of chromatin during osteoblast differentiation.

  7. These results suggested that endogenous PTH enhanced BMPR2 expression by a cAMP/PKA/CREB pathway in osteoblasts, and increased RUNX2 expression through transduction of the BMP/pSMAD1/5/8 signaling pathway

  8. suggest that RUNX2 and USAG-1 (show SOSTDC1 Proteins) act in an antagonistic manner

  9. results provide evidence that WWP2 (show WWP2 Proteins) serves as a positive regulator of osteogenesis by augmenting RUNX2 transactivation in a non-proteolytic mono-ubiquitination manner.

  10. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 pathway.

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 promotes autophagy in metastatic breast cancer cells by increasing acetylation of alpha-tubulin (show TUBA4A Proteins) sub-units of microtubules.

  2. Mutation in the RUNX2 gene is associated with acute myeloid leukemia (show BCL11A Proteins) patients with lympho-myeloid clonal hematopoiesis.

  3. present observations strongly suggest that RUNX2/mutant p53 (show TP53 Proteins)/TAp63-regulatory axis is one of the key determinants of SAHA sensitivity of p53 (show TP53 Proteins)-mutated pancreatic cancer cells

  4. All the three novel RUNX2 mutations significantly reduced the transactivation activity of RUNX2 on osteocalcin (show BGLAP Proteins) promoter.

  5. miR (show MLXIP Proteins)-466-mediated attenuation of RUNX2 as a novel therapeutic approach to regulate prostate cancer growth, particularly metastasis to bone.

  6. miR (show MLXIP Proteins)-203 has a crucial role in suppressing heterotopic ossification by directly targeting Runx2.

  7. mechanical load upregulates expression of Runx2 gene via potentiation of PC1 (show PCSK1 Proteins)-JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.

  8. the Runx2 knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (show GRK4 Proteins)), the sensor of cellular metabolism. Importantly, the Runx2 knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 inhibition and AMPKalpha (show GRK4 Proteins) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (show GRK4 Proteins) levels.

  9. RUNX2 mutation disturbs the modulatory effects of dental follicle cells and periodontal ligament cells on the differentiation of osteoclasts and osteoblasts, thereby interfering with bone remodelling. These effects may contribute in part to the pathological manifestations of retention of primary teeth and delayed eruption of permanent teeth in patients with cleidocranial dysplasia.

  10. RUNX2/P57 (show CDKN1C Proteins) gene expression is strongly activated, in a process that is accompanied by enrichment of activating histone marks (H3K4me3, H3ac, and H3K27ac) at the P1 promoter region, to control osteogenic lineage commitment of umbilical cord derived mesenchymal stem cells.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (show MGP Proteins) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 pathway.

RUNX2 Protein Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt-related transcription factor 2a (runx2a)
  • transcription factor Cbfa1 (runx2)
  • runt-related transcription factor 2 (RUNX2)
  • runt-related transcription factor 2 (runx2)
  • runt related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (LOC100339156)
  • runt-related transcription factor 2-like (LOC100737965)
  • AML3 protein
  • Cbf protein
  • CBF-alpha-1 protein
  • Cbfa-1 protein
  • CBFA1 protein
  • CCD protein
  • CCD1 protein
  • CLCD protein
  • LS3 protein
  • OSF-2 protein
  • OSF2 protein
  • PEA2aA protein
  • Pebp2a1 protein
  • pebp2a2 protein
  • PEBP2aA protein
  • pebp2aa1 protein
  • Pebpa2a protein
  • RUNX2 protein

Protein level used designations for RUNX2

runt-related transcription factor 2 , transcription factor Runx2a , transcription factor Cbfa1 , runt-related transcription factor 2-like , AKV core binding factor , CBF-alpha-1 , PEA2-alpha A , PEBP2 alpha A , SL3-3 enhancer factor 1 alpha A subunit , acute myeloid leukemia 3 protein , core binding factor alpha 1 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt domain, alpha subunit 1 , PEBP2-alpha A , SL3/AKV core-binding factor alpha A subunit , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , runt-related factor 2 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II , core binding factor alpha 1 subunit

GENE ID SPECIES
405784 Danio rerio
445986 Takifugu rubripes
449531 Canis lupus familiaris
472017 Pan troglodytes
703331 Macaca mulatta
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
12393 Mus musculus
860 Homo sapiens
474923 Canis lupus familiaris
536911 Bos taurus
100008943 Oryctolagus cuniculus
367218 Rattus norvegicus
100037059 Xenopus laevis
373919 Gallus gallus
100734175 Cavia porcellus
100033890 Equus caballus
100155806 Sus scrofa
100339156 Oryctolagus cuniculus
100861217 Capra hircus
101115489 Ovis aries
100737965 Sus scrofa
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