SET Domain Containing (Lysine Methyltransferase) 7 Proteins (SETD7)

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. Additionally we are shipping SETD7 Antibodies (102) and SETD7 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SETD7 80854 Q8WTS6
SETD7 73251 Q8VHL1
Rat SETD7 SETD7 689954  
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Top SETD7 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process RPLP0 dissolution curves 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$3,001.17
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$190.93
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$466.67
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$466.67
Details

SETD7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

More Proteins for SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) Interaction Partners

Human SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) interaction partners

  1. Methylation at K436 and K595 respectively by Set7 increases the stability and DNA binding ability of Gli3 (show GLI3 Proteins), resulting in an enhancement of Shh (show SHH Proteins) signaling activation.

  2. the methyltransferase Set9 potentiates TGF-beta (show TGFB1 Proteins) signaling by targeting Smad7 (show SMAD7 Proteins), an inhibitory downstream effector.

  3. SETD7 plays a critical role in HCC (show FAM126A Proteins), and its immunohistochemistry signature provides potential clinical significance for personalized prediction of HCC (show FAM126A Proteins) prognosis.

  4. These findings underscore the role of KMT7 as an important monomethyltransferase regulating HIV transcription through Tat (show TAT Proteins).

  5. High SET7 expression is associated with breast cancer.

  6. SET7 was required for GATA1 (show GATA1 Proteins)-induced breast tumor angiogenesis and growth in nude mice. GATA1 (show GATA1 Proteins) and SET7 are independent poor prognostic factors in breast cancer.

  7. SET7/SET9-mediated YY1 (show YY1 Proteins) methylation was shown to be involved in YY1 (show YY1 Proteins)-regulated gene transcription and cell proliferation.

  8. These results demonstrate that S...O chalcogen bonds contribute to AdoMet (show MAT1A Proteins) recognition and can enable methyltransferases to distinguish between substrate and product.

  9. Reduced expression of SET7 is associated with gastric cancer progression.

  10. study identified a novel locus associated with serum lycopene concentrations and results raise a number of possibilities regarding the nature of the relationship between SETD7 and lycopene, both independently associated with prostate cancer.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) interaction partners

  1. the methyltransferase Set9 potentiates TGF-beta (show TGFB1 Proteins) signaling by targeting Smad7 (show SMAD7 Proteins), an inhibitory downstream effector.

  2. SETD7 plays an important role in intestinal epithelial cell (IEC) biology during infection.

  3. We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells.

  4. SETD7 is required for Wnt (show WNT2 Proteins)-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP (show YAP1 Proteins) facilitates Wnt (show WNT2 Proteins)-induced nuclear accumulation of beta-catenin (show CTNNB1 Proteins).

  5. SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.

  6. Data indicate that the ability of transcription factor Pdx1 (show PDX1 Proteins) to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9.

  7. study found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes.

  8. The response to hyperglycemia in vascular endothelial cells involves Set7 mediated changes in chromatin remodeling and gene expression.

  9. Set7/9-mediated methylation of p53 (show TP53 Proteins) does not represent a major regulatory event and does not appreciably control p53 (show TP53 Proteins) activity in vivo.

  10. Set7/9 is dispensable for p53 (show TP53 Proteins) function in the mouse.

SETD7 Protein Profile

Protein Summary

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the -K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Gene names and symbols associated with SETD7

  • SET domain containing lysine methyltransferase 7 (SETD7)
  • SET domain containing (lysine methyltransferase) 7 (setd7)
  • SET domain containing (lysine methyltransferase) 7 (Setd7)
  • 1600028F23Rik protein
  • H3K4MT protein
  • KMT7 protein
  • mKIAA1717 protein
  • Set7 protein
  • Set7/9 protein
  • SET9 protein
  • zgc:92330 protein
  • zgc:101860 protein

Protein level used designations for SETD7

H3-K4-HMTase SETD7 , SET domain-containing protein 7 , histone H3-K4 methyltransferase SETD7 , histone H3-lysine 4-specific methyltransferase , histone-lysine N-methyltransferase SETD7 , lysine N-methyltransferase 7 , H3-K4 methyltransferase

GENE ID SPECIES
80854 Homo sapiens
436729 Danio rerio
73251 Mus musculus
689954 Rattus norvegicus
476079 Canis lupus familiaris
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