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Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. Additionally we are shipping SETD7 Antibodies (93) and SETD7 Kits (5) and many more products for this protein.
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Human SETD7 Protein expressed in Escherichia coli (E. coli) - ABIN2004086
Martens, Verlaan, Kalkhoven, Zantema: Cascade of distinct histone modifications during collagenase gene activation. in Molecular and cellular biology 2003
High SET7 expression is associated with breast cancer.
SET7 was required for GATA1 (show GATA1 Proteins)-induced breast tumor angiogenesis and growth in nude mice. GATA1 (show GATA1 Proteins) and SET7 are independent poor prognostic factors in breast cancer.
SET7/SET9-mediated YY1 (show YY1 Proteins) methylation was shown to be involved in YY1 (show YY1 Proteins)-regulated gene transcription and cell proliferation.
These results demonstrate that S...O chalcogen bonds contribute to AdoMet (show MAT1A Proteins) recognition and can enable methyltransferases to distinguish between substrate and product.
Reduced expression of SET7 is associated with gastric cancer progression.
study identified a novel locus associated with serum lycopene concentrations and results raise a number of possibilities regarding the nature of the relationship between SETD7 and lycopene, both independently associated with prostate cancer.
Lysine methylation by SETD7 is important for the fine-tuning of reactive oxygen species signaling through its regulation on pro-inflammatory responses.
Knock-down of SETD7 causes differentiation defects in human embryonic stem cell including delay in both the silencing of pluripotency-related genes and the induction of differentiation genes.
Unleashed expression of Mdm2 (show MDM2 Proteins) in cancer patients with diminished expression of Set7/9 is associated with poor survival outcome.
Based on our results miR (show MLXIP Proteins)-153 inhibits proliferation and suppresses EMT (show ITK Proteins) and the invasive potential of ovarian cancer cells through downregulation of SET7 and ZEB2, supporting the pursuit of miR (show MLXIP Proteins)-153 as a potential target for ovarian cancer intervention.
SETD7 is required for Wnt (show WNT2 Proteins)-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP (show YAP1 Proteins) facilitates Wnt (show WNT2 Proteins)-induced nuclear accumulation of beta-catenin (show CTNNB1 Proteins).
SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.
Data indicate that the ability of transcription factor Pdx1 (show PDX1 Proteins) to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9.
study found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes.
The response to hyperglycemia in vascular endothelial cells involves Set7 mediated changes in chromatin remodeling and gene expression.
Set7/9-mediated methylation of p53 (show TP53 Proteins) does not represent a major regulatory event and does not appreciably control p53 (show TP53 Proteins) activity in vivo.
Set7/9 is dispensable for p53 (show TP53 Proteins) function in the mouse.
Define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation.
Pdx1 (show PDX1 Proteins)-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes.
Methylation of p53 (show TP53 Proteins) by Set7 mediates p53 (show TP53 Proteins) acetylation and activity in vivo.
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the -K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
, SET domain-containing protein 7
, histone H3-K4 methyltransferase SETD7
, histone H3-lysine 4-specific methyltransferase
, histone-lysine N-methyltransferase SETD7
, lysine N-methyltransferase 7
, H3-K4 methyltransferase