anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Antibodies

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Additionally we are shipping SETD8 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SETD8 387893 Q9NQR1
SETD8 67956 Q2YDW7
SETD8    
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Top anti-SETD8 Antibodies at antibodies-online.com

Showing 10 out of 126 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, IHC (p), WB The anti-SET07 Mab (ABIN387779) is used in Western blot to detect SET07 in SAOS-2 (lane 1) and NIH/3T3 cell lysates (lane 2). Formalin-fixed and paraffin-embedded human testis tissue reacted with SET07 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB The anti-SET07 Mab (ABIN387780) is used in Western blot to detect SET07 in 293 cells. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of SET07 polyclonal antibody (ABIN387992) in HeLa cell lysate (Lane 1) and NIH/3T3 cell lysate (Lane 2). SET07 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SETD8 antibody (Center) (ABIN390472) in 293 cell line lysates (35 µg/lane). SETD8 (arrow) was detected using the purified polyclonal antibody. SETD8 Antibody (Center) (ABIN390472) IHC analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SET07 Antibody (C-term) (ABIN387993) in K562 cell line lysates (35 µg/lane). SET07 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SETD8 antibody (Center) in 293 cell line lysates (35ug/lane). SETD8 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$323.13
Details

SETD8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus)


More Antibodies against SETD8 Interaction Partners

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. miR (show MLXIP Antibodies)-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of breast cancer and a focal point for possible therapeutic intervention.

  2. In non-small cell lung cancer cells, SETD8 expression suppression is involved in tumorigenesis and metastasis.

  3. SET8 and ZEB1 (show ZEB1 Antibodies) are functionally interdependent in promoting the epithelial-mesenchymal transition and enhancing the invasive potential of prostate cancer cells in vitro.

  4. SET8 expression is associated with overall survival in gastric cancer

  5. analysis of a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex

  6. This study showed SCF (show KITLG Antibodies)(beta-TRCP (show BTRC Antibodies)) earmarks Set8 for ubiquitination and degradation in a casein kinase I (show CSNK1D Antibodies)-dependent manner, which is activated by DNA-damaging agents.

  7. Overall, the results revealed that miR (show MLXIP Antibodies)-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis.

  8. commonality of SPS8I1-3 against SETD8, together with their distinct structures and mechanisms for SETD8 inhibition, argues for the collective application of these compounds as SETD8 inhibitors

  9. SET8 is required for 53BP1 (show TP53BP1 Antibodies) recruitment and efficient repair of DSB.

  10. These data suggest that there are significant associations between the miR (show MLXIP Antibodies)-502-binding site single nucleotide polymorphism in the 3'-UTR (show UTS2R Antibodies) of SET8 and the TP53 (show TP53 Antibodies) codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. PR-Set7 is a direct target of Cul4A (show CUL4A Antibodies) for degradation and involved in the formation of lung tumors in the conditional Cul4A (show CUL4A Antibodies) transgenic mouse model.

  2. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (show GATA2 Antibodies) expression.

  3. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  4. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Antibodies), HYPB (show SETD2 Antibodies), NSD1 (show NSD1 Antibodies), and NSD2 (show WHSC1 Antibodies) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Antibodies), and Pr-Set7 were not affected by ubH2A.

  5. Data indicate a vital link between GATA-1 (show GATA1 Antibodies) and the histone H4 (show HIST1H4H Antibodies) lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  6. Pr-set7 knockdown caused increased gammaH2AX (show H2AFX Antibodies) foci on chromosomes indicating DNA damage on chromosomes.

  7. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  8. the SET8 and PCNA (show PCNA Antibodies) interaction couples H4-K20 (show KRT20 Antibodies) methylation with DNA replication

  9. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

  10. Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.

SETD8 Antigen Profile

Protein Summary

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Gene names and symbols associated with SETD8

  • SET domain containing (lysine methyltransferase) 8 (SETD8) antibody
  • SET domain containing (lysine methyltransferase) 8 (Setd8) antibody
  • 2410195B05Rik antibody
  • AA617402 antibody
  • AW536475 antibody
  • KMT5A antibody
  • PR-SET7 antibody
  • SET07 antibody
  • SET8 antibody

Protein level used designations for SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8

GENE ID SPECIES
387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
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