SET and MYND Domain Containing 2 Proteins (SMYD2)

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008].. Additionally we are shipping SET and MYND Domain Containing 2 Antibodies (68) and SET and MYND Domain Containing 2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMYD2 56950 Q9NRG4
SMYD2 226830 Q8R5A0
SMYD2 289372 Q7M6Z3
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Top SET and MYND Domain Containing 2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,201.00
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$3,210.17
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,210.17
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,210.17
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,219.33
Details

SMYD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for SET and MYND Domain Containing 2 (SMYD2) Interaction Partners

Human SET and MYND Domain Containing 2 (SMYD2) interaction partners

  1. The SMYD2 may promote BMP signaling by directly methylating BMPR2, which, in turn, stimulates BMPR2 kinase activity and activation of the BMP pathway.

  2. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein.

  3. SMYD2 knockdown confers relative resistance to human AML (show RUNX1 Proteins) cells against multiple classes of DNA damaging agents.

  4. Substrate crevices of Smyd2 and Smyd3 (show SMYD3 Proteins) show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding.

  5. High expression of SMYD2 is associated with chronic lymphocytic leukemia.

  6. Study reveals a collection of 10 enriched sequence motifs in Kme1 sites that were identified upon SMYD2 overexpression which were also downregulated in response to SMYD2 knockdown. These findings suggest that these motifs reflect the substrate specificity of SMYD2 in esophageal squamous cell carcinoma cell line.

  7. Results show that high expression levels of SMYD2, SETD3 (show SETD3 Proteins), and NO66 (show C14orf169 Proteins) in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.

  8. Suggest that SMYD2 plays a role in tumor progression and might be a useful prognosticator in HPV-unrelated, nonmultiple head and neck squamous cell carcinomas.

  9. SMYD2-mediated methylation negatively regulates PTEN tumor suppressor activity and results in activation of the phosphatidylinositol 3-kinase-AKT (show AKT1 Proteins) pathway.

  10. Comprehensive motif-based searches and mutational analysis further established four additional substrates of SMYD2.

Mouse (Murine) SET and MYND Domain Containing 2 (SMYD2) interaction partners

  1. two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins)/SMYD2 and SMYD2/TNF-alpha (show TNF Proteins)/NF-kappaB (show NFKB1 Proteins)/SMYD2.

  2. a pivotal role for SMYD2 in promoting pancreatic cancer.

  3. Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6 (show IL6 Proteins)) and tumor necrosis factor alpha (TNF-alpha (show TNF Proteins)) production. production.

  4. Smyd2 is a lysine methyltransferase which has, next to its nuclear activity, specific regulatory functions in the cytoplasm of heart and skeletal muscle cells.

  5. Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ

  6. Sin3A (show SIN3A Proteins)-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 [Symd2]

  7. results show that Smyd2 negatively regulates p53 (show TP53 Proteins)-responsive genes in a p53 (show TP53 Proteins)-dependent manner

Zebrafish SET and MYND Domain Containing 2 (SMYD2) interaction partners

  1. Findings suggest that SMYD2 (SET and MYND domain containing protein 2), a histone lysine methyltransferase, plays a critical role at early stages of development.

SET and MYND Domain Containing 2 (SMYD2) Protein Profile

Protein Summary

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006

Gene names and symbols associated with SMYD2

  • SET and MYND domain containing 2 (SMYD2)
  • SET and MYND domain containing 2 (LOC100230503)
  • SET and MYND domain containing 2 (Smyd2)
  • SET and MYND domain containing 2 (smyd2)
  • SET and MYND domain containing 2a (smyd2a)
  • 1110020E07Rik protein
  • 4930402C15 protein
  • HSKM-B protein
  • im:7146196 protein
  • KMT3C protein
  • smyd2 protein
  • smyd2-a protein
  • wu:fc02f02 protein
  • zgc:110553 protein
  • Zmynd14 protein

Protein level used designations for SMYD2

SET and MYND domain containing 2 , SET and MYND domain-containing protein 2-like , N-lysine methyltransferase SMYD2 , SET and MYND domain-containing protein 2 , histone methyltransferase SMYD2 , lysine N-methyltransferase 3C , zinc finger, MYND domain containing 14 , Histone methyltransferase SMYD2 , SET and MYND domain-containing 2 , HSKM-B protein , Histone methyltransferase SMYD2-A , N-lysine methyltransferase SMYD2-A , SET and MYND domain-containing protein 2A , histone methyltransferase SMYD2-A

GENE ID SPECIES
457729 Pan troglodytes
709375 Macaca mulatta
100023305 Monodelphis domestica
100052774 Equus caballus
100230503 Taeniopygia guttata
100344249 Oryctolagus cuniculus
100404005 Callithrix jacchus
100439768 Pongo abelii
100603309 Nomascus leucogenys
56950 Homo sapiens
226830 Mus musculus
421361 Gallus gallus
480026 Canis lupus familiaris
100294706 Sus scrofa
615229 Bos taurus
289372 Rattus norvegicus
379943 Xenopus laevis
541423 Danio rerio
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