SMYD2A Protein (His tag)
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- Target See all SMYD2A Proteins
- SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This SMYD2A protein is labelled with His tag.
- Purpose
- Recombinant Human SMYD2/KMT3C Protein (His Tag)
- Sequence
- Met 1-His 433
- Characteristics
- A DNA sequence encoding the full length of human SMYD2 (NP_064582.2) (Met 1-His 433) was expressed, with a polyhistidine tag at the N-terminus.
- Purity
- > 97 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SMYD2A Protein
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SET and MYND Domain Containing 2a (SMYD2A) (AA 1-433) protein (GST tag)
SMYD2A Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
SET and MYND Domain Containing 2a (SMYD2A) (AA 1-433) protein (Strep Tag)Crystallography grade SMYD2A Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
SET and MYND Domain Containing 2a (SMYD2A) (AA 1-433) protein (Strep Tag)Crystallography grade SMYD2A Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
SET and MYND Domain Containing 2a (SMYD2A) protein (Myc-DYKDDDDK Tag)SMYD2A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 10 % glycerol, pH 8.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))
- Alternative Name
- SMYD2/KMT3C (SMYD2A Products)
- Synonyms
- HSKM-B Protein, KMT3C Protein, ZMYND14 Protein, 1110020E07Rik Protein, 4930402C15 Protein, Zmynd14 Protein, smyd2-a Protein, im:7146196 Protein, smyd2 Protein, wu:fc02f02 Protein, zgc:110553 Protein, si:dkey-121j17.3 Protein, zgc:136609 Protein, SET and MYND domain containing 2 Protein, SET and MYND domain containing 2 S homeolog Protein, SET and MYND domain containing 2a Protein, SET and MYND domain containing 2b Protein, SMYD2 Protein, Smyd2 Protein, smyd2.S Protein, smyd2a Protein, smyd2b Protein
- Background
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Background: SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cells differentiation. SMYD2 mRNA is most highly expressed in heart and brain tissue. Over-expressed SMYD2 localizes to the cytoplasm and the nucleus in 293T cells. SMYD2 appears to restrain cell proliferation, likely through direct modulation of chromatin structure. Patients with SMYD2-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors, and SMYD2 positivity was independently associated with a worse outcome in the multivariate analysis. SMYD2 plays an important role in tumor cell proliferation through its activation/overexpression and regards as a prognosticator and potential therapeutic target in esophageal squamous cell carcinoma (ESCC).
Synonym: HSKM-B,KMT3C,ZMYND14
- Molecular Weight
- 52 kDa
- NCBI Accession
- NP_064582
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