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SIVA1 encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. Additionally we are shipping SIVA1 Kits (11) and SIVA1 Proteins (9) and many more products for this protein.
Showing 10 out of 41 products:
Human Polyclonal SIVA1 Primary Antibody for EIA, IF - ABIN1450104
Jacobs, Basak, Murray, Pathak, Attardi: Siva is an apoptosis-selective p53 target gene important for neuronal cell death. in Cell death and differentiation 2007
Show all 4 references for ABIN1450104
Human Polyclonal SIVA1 Primary Antibody for ELISA - ABIN564613
Diegmann, Junker, Loncarevic, Michel, Schimmel, von Eggeling: Immune escape for renal cell carcinoma: CD70 mediates apoptosis in lymphocytes. in Neoplasia (New York, N.Y.) 2006
Show all 3 references for ABIN564613
Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.
These findings collectively reveal a novel role for the p53 (show TP53 Antibodies) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (show TP53 Antibodies).
Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
electrical stimulation -inducible SIVA1 modulates p53 (show TP53 Antibodies) activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53 (show TP53 Antibodies)/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization
SIVA1 interacts with RAD18 (show RAD18 Antibodies) and serves as a molecular bridge between RAD18 (show RAD18 Antibodies) and PCNA (show PCNA Antibodies), thus targeting the E3 ligase activity of RAD18 (show RAD18 Antibodies) onto PCNA (show PCNA Antibodies).
Siva1 promotes the ubiquitination and degradation of ARF (show CDKN2A Antibodies), which in turn affects the stability of p53 (show TP53 Antibodies).
Upon stimulation of thromboxane A2, degradation of Siva1 is impeded, resulting in an accumulation of the protein, which translocates from the nucleus to the cytosol.
negative regulator of IL-2 (show ZEB1 Antibodies) gene expression in Treg cells
Data show that low levels of Siva1 and Ser16-phosphorylated stathmin (show STMN1 Antibodies) correlate with high metastatic states of breast cancer cells.
These findings suggest that the caspase (show CASP3 Antibodies)-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication.
Data indicate that p53 (show TP53 Antibodies) target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
SIVA is a direct transcriptional target for the tumor suppressors p53 (show TP53 Antibodies) and E2F1 (show E2F1 Antibodies)
Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53 (show TP53 Antibodies)-dependent apoptosis in cerebellar granule neurons.
lysophosphatidic acid 2 (show PTOV1 Antibodies) receptor mediates down-regulation of Siva-1 to promote cell survival
Data show that SLIMMER (show FHL1 Antibodies) delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
CD27-binding (Siva) protein
, apoptosis regulatory protein Siva
, CD27-binding protein
, Cd27 binding protein