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Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Additionally we are shipping SAE1 Proteins (19) and SAE1 Kits (11) and many more products for this protein.
Showing 10 out of 131 products:
Human Polyclonal SAE1 Primary Antibody for ELISA, WB - ABIN250021
Desterro, Rodriguez, Kemp, Hay: Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. in The Journal of biological chemistry 1999
Human Monoclonal SAE1 Primary Antibody for IF, IHC (p) - ABIN564342
Fujimoto, Matsushita, Hamaguchi, Kaji, Asano, Ogawa, Yamaoka, Fujikawa, Tsukada, Sato, Echigo, Hasegawa, Takehara: Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort. in Annals of the rheumatic diseases 2012
the expression of SENP8 (show SENP8 Antibodies), SAE1, PIAS1 (show PIAS1 Antibodies), PIAS2 (show PIAS2 Antibodies) and ZMIZ1 (show ZMIZ1 Antibodies) is deregulated in the majority of PTC (show F9 Antibodies) tissues, likely contributing to the PTC (show F9 Antibodies) phenotype.
as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells.
Data indicate the role of anti-SUMO activating enzyme SAE1 and SAE2 (show RBBP8 Antibodies) antibody as marker of dermatomyositis.
Data show that the SAE2 (show RBBP8 Antibodies) subunit of the small ubiquitin-like modifier (SUMO (show SUMO1 Antibodies)) E1 is autoSUMOylated at residue Lys (show LYZ Antibodies)-236, and SUMOylation was catalyzed by Ubc9 (show UBE2I Antibodies) at several additional Lys (show LYZ Antibodies) residues surrounding the catalytic Cys (show DNAJC5 Antibodies)-173 of SAE2 (show RBBP8 Antibodies).
loss of SAE1/2 activity drives synthetic lethality with Myc (show MYC Antibodies); inactivation of SAE2 (show RBBP8 Antibodies) leads to mitotic catastrophe and cell death upon Myc (show MYC Antibodies) hyperactivation; findings in Myc (show MYC Antibodies)-high breast cancers suggest low tumor SAE1 and SAE2 (show RBBP8 Antibodies) correlates metastasis-free survival
The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.
structures of heterodimeric Sae1/Sae2 (show RBBP8 Antibodies)-Mg.ATP and Sae1/Sae2 (show RBBP8 Antibodies)-SUMO-1 (show SUMO1 Antibodies)-Mg.ATP complexes
SUMO-1 (show SUMO1 Antibodies) controls the protein stability and the biological function of phosducin (show PDC Antibodies).
sae1 is essential for the maintenance of hematopoietic stem/progenitor cells during fetal hematopoiesis in zebrafish.
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999
SUMO-1 activating enzyme E1 N subunit
, SUMO-1 activating enzyme subunit 1
, SUMO-activating enzyme subunit 1
, activator of SUMO1
, sentrin/SUMO-activating protein AOS1
, ubiquitin-like 1-activating enzyme E1A
, ubiquitin-like protein SUMO-1 activating enzyme
, ubiquitin-like (sentrin) activating enzyme E1A
, ubiquitin-like 1 (sentrin) activating enzyme E1A
, ubiquitin-like 1 (sentrin) activating enzyme subunit 1
, SUMO-activating enzyme E1 N subunit
, SUMO1 activating enzyme subunit 2a
, Ubiquitin-like 1-activating enzyme E1A