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anti-Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) Antibodies

SGCA encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Additionally we are shipping SGCA Proteins (8) and SGCA Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SGCA 6442 Q16586
SGCA 20391 P82350
SGCA 303468  
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Top anti-SGCA Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa/HepG2/Jurkat cells, using SGCA Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mouse Rabbit Un-conjugated WB Anti- SGCA Picoband antibody, Western blotting All lanes: Anti SGCA  at 0.5ug/ml Lane 1: Rat Skeletal Muscle Tissue Lysate at 50ug Lane 2: Mouse Skeletal Muscle Tissue Lysate at 50ug Predicted bind size: 43KD Observed bind size: 43KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB SGCA Antibody (Center)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SGCA antibody detected the SGCA protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of SGCA expression in transfected 293T cell line by SGCA monoclonal antibody (M01), clone 3C4. Lane 1: SGCA transfected lysate(42.9 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Rabbit Un-conjugated IP, WB Western blot analysis of Alpha-sarcoglycan expression in HuvEc (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 14 Days
$201.19
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of SGCA expression in transfected 293T cell line by SGCA monoclonal antibody (M01), clone 3C4.Lane 1: SGCA transfected lysate(42.9 KDa).Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged SGCA is 1 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details

SGCA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-SGCA Antibodies

  1. Human Polyclonal SGCA Primary Antibody for ELISA, WB - ABIN1534624 : Roberds, Leturcq, Allamand, Piccolo, Jeanpierre, Anderson, Lim, Lee, Tomé, Romero: Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy. in Cell 1994 (PubMed)

More Antibodies against SGCA Interaction Partners

Human Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) interaction partners

  1. Results show that HRD1 (show SYVN1 Antibodies) and RFP2 (show TRIM13 Antibodies) contributes are required for the disposal of V247M alpha-sarcoglycan mutant.

  2. 2 members of a Spanish family with muscular dystrophy had a new missense mutation c409G>A, p.Glu137Lys in exon 5 of the alpha-sarcoglycan gene, as well as a paternal c739G>A, p.Val24Met mutation inexon 6.

  3. DNA analysis demonstrated homozygosity for a point mutation (574C>T) in the alpha-sarcoglycan gene.

  4. E-cadherin (show CDH1 Antibodies),alpha-dystroglycan and beta-dystroglycan levels were decreased in the oesophageal primary tumour samples, despite the presence of normal levels of dystroglycan (show DAG1 Antibodies) mRNA.

  5. This study reported recessive founder LGMD2D for the Magdalen Islands, an archipelago (show FBXW7 Antibodies) settled in the XIXth century, largely by Acadian immigrants.

  6. Peptide sequences in alpha-DG are substrates for protein-O-mannose N-acetylglucosaminyltransferase (show GCNT2 Antibodies) 1 (POMGnT1 (show POMGNT1 Antibodies)), demonstrated when a library of mannopeptides is generated which corresponds to sequences of the mucin (show SLC13A2 Antibodies)-like stem region of alpha-DG.

  7. Long-term, sustainable gene expression of alpha-sarcoglycan was observed following gene transfer mediated by AAV.

  8. Absence of members of the dystrophin (show DMD Antibodies)-associated glycoprotein complex constitutes a permissive environment for spontaneous development of embryonal rhabdomyosarcoma associated with mutation of p53 (show TP53 Antibodies) and mutation or altered splicing of Mdm2 (show MDM2 Antibodies).

  9. Two adult brothers with a mild form of LGMD2D, compound heterozygous for two missense mutations of the SGCA gene (Arg77Cys, Val247Met), presented with respiratory insufficiency while they were still ambulatory.

  10. Biglycan (show BGN Antibodies) is a ligand for two members of the sarcoglycan (show SGCD Antibodies) complex and regulates their expression at discrete developmental ages.

Mouse (Murine) Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) interaction partners

  1. The differential expression of two alpha-SG mRNAs during mouse embryonic development may be a consequence of the differential regulation of both promoters by myogenic and cardiogenic factors.

  2. Loss of sarcoglycan (show SGCD Antibodies) is associated with loss of miRNA669a and myopathy.

  3. Sgca-;Sgce (show SGCE Antibodies)-null mouse shows a complete loss of residual sarcoglycans and a strong reduction in both dystrophin (show DMD Antibodies) and dystroglycan (show DAG1 Antibodies).

  4. Impaired proliferation of Sgca-null myogenic precursors was confirmed by single fiber analysis and this difference correlated with Sgca expression during myogenic progenitor cell proliferation.

  5. Absence of members of the dystrophin (show DMD Antibodies)-associated glycoprotein complex constitutes a permissive environment for spontaneous development of embryonal rhabdomyosarcoma associated with mutation of p53 (show TP53 Antibodies) and mutation or altered splicing of Mdm2 (show MDM2 Antibodies).

  6. These findings suggest that the sarcoglycan (show SGCD Antibodies) complex serves a mechanical function in the diaphragm by contributing to muscle passive stiffness and to the modulation of the contractile properties of the muscle.

  7. Muscle masses were 40-100% larger for Sgca-null compared with age- and gender-matched wild-type mice, with the majority of the increased muscle mass for Sgca-null mice attributable to greater connective tissue and water contents

  8. Diaphragm from Sgca-null mouse presents a clear dystrophic phenotype, with necrosis, regeneration, fibre hypertrophy and splitting, excess of collagen and fatty infiltration.

  9. Deficiency of Sgca differently affects fast- and slow-twitch skeletal muscles.

  10. The alpha-SG promoter is activated by MyoD (show MYOD1 Antibodies), which interacts with TFIID (show TBP Antibodies) and TFIIB (show GTF2B Antibodies) in a protein complex differentially located at the distal promoter and around the proximal promoter during myogenic cell differentiation.

SGCA Antigen Profile

Protein Summary

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SGCA

  • 50-kda dystrophin-associated glycoprotein (DAG2) antibody
  • sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) (SGCA) antibody
  • sarcoglycan, alpha (dystrophin-associated glycoprotein) (Sgca) antibody
  • 50-DAG antibody
  • 50DAG antibody
  • A2 antibody
  • adhalin antibody
  • ADL antibody
  • Asg antibody
  • DAG2 antibody
  • DMDA2 antibody
  • LGMD2D antibody
  • SCARMD1 antibody
  • Sgca antibody

Protein level used designations for SGCA

50 kDa dystrophin-associated glycoprotein , 50DAG , adhalin , alpha-SG , alpha-sarcoglycan , dystroglycan-2 , 50kD DAG , sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

GENE ID SPECIES
100009178 Oryctolagus cuniculus
6442 Homo sapiens
20391 Mus musculus
303468 Rattus norvegicus
Selected quality suppliers for anti-SGCA (SGCA) Antibodies
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