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SOSTDC1 is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. Additionally we are shipping SOSTDC1 Antibodies (47) and SOSTDC1 Proteins (9) and many more products for this protein.
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Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 (show CCNA2 ELISA Kits) and cyclin E2 (show CCNE2 ELISA Kits).
Results conclude that the transcriptional repressor E4BP4 (show NFIL3 ELISA Kits) plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 (show NFIL3 ELISA Kits) silencing.
Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer
Unliganded VDR (show CYP27B1 ELISA Kits) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 (show DKKL1 ELISA Kits) and SOSTDC1.
DNA methylation (show HELLS ELISA Kits) is involved in the down-regulation of SOSTDC1 expression in gastric cancer.
SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer.
Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women.
genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors.
Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways
USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist.
Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum.
suggest that RUNX2 (show RUNX2 ELISA Kits) and USAG-1 act in an antagonistic manner
the in vivo inter-relationships between Bmp7 (show BMP7 ELISA Kits) and Usag-1, was examined.
Findings strongly suggest that Wise and Sost (show SOST ELISA Kits) are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 (show LRP5 ELISA Kits) and control the balance or levels of Wnt (show WNT2 ELISA Kits) signaling.
Interactions between BMP-7 (show BMP7 ELISA Kits) and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations
Sost (show SOST ELISA Kits) and its paralog Sostdc1 coordinate digit number in a Gli3 (show GLI3 ELISA Kits)-dependent manner.
Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor (show CTGF ELISA Kits)) and gremlin (show GREM1 ELISA Kits) in islets after high-fat diet.
The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7 (show BMP7 ELISA Kits)-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 (show HOXA13 ELISA Kits) and USAG-1.
The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.
sclerostin domain containing 1
, sclerostin domain-containing protein 1
, Sclerostin domain-containing protein 1
, uterine sensitization-associated gene 1 protein
, wnt-signaling modulator
, cystine-knot containing secreted protein
, ectodermal BMP inhibitor
, uterine sensitization-associated protein-1
, sclerostin-like protein
, uterine sensitization-associated protein 1
, context-dependent activator and inhibitor of Wnt signalling protein Wise