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Sialic Acid Binding Ig-Like Lectin 5 Proteins (SIGLEC5)

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Additionally we are shipping SIGLEC5 Antibodies (106) and SIGLEC5 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC5 8778 O15389
SIGLEC5 233186 Q920G3
Rat SIGLEC5 SIGLEC5 292843  
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Top SIGLEC5 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_CHO Cells Human Fc Tag   25 μg Log in to see 10 to 12 Days
$201.11
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human Fc Tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$616.00
Details

SIGLEC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , ,
Mouse (Murine) ,
,

Top referenced SIGLEC5 Proteins

  1. Human SIGLEC5 Protein expressed in CHO Cells - ABIN2666957 : Angata, Varki: Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. in The Journal of biological chemistry 2000 (PubMed)
    Show all 5 references for ABIN2666957

  2. Human SIGLEC5 Protein expressed in HEK-293 Cells - ABIN2181761 : Cornish, Freeman, Forbes, Ni, Zhang, Cepeda, Gentz, Augustus, Carter, Crocker: Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. in Blood 1998 (PubMed)
    Show all 3 references for ABIN2181761

  3. Human SIGLEC5 Protein expressed in Human Cells - ABIN2004785 : Avril, Freeman, Attrill, Clarke, Crocker: Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. in The Journal of biological chemistry 2005 (PubMed)

More Proteins for Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. An unbiased screen revealed Hsp70 (show HSP70 Proteins) as a ligand for Siglec-5 and Siglec-14 (show SIGLEC14 Proteins). Hsp70 (show HSP70 Proteins) stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 (show SIGLEC14 Proteins) is pro-inflammatory.

  2. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.

  3. we found that secretory IgA is taken up by M cells via the Dectin-1 (show CLEC7A Proteins) receptor, with the possible involvement of Siglec-5 acting as a co-receptor.

  4. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.

  5. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.

  6. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.

  7. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.

  8. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.

  9. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.

  10. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated (show SULF1 Proteins) oligosaccharides containing sialic acid.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. indicate that Siglec-9 (show SIGLEC9 Proteins) affects several different signaling pathways in IL-4 (show IL4 Proteins)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Proteins) in Siglec-9 (show SIGLEC9 Proteins)-expressing RAW264 cells

  2. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Proteins) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  3. These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.

  4. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Proteins)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Proteins)) interaction and endotoxemia.

  5. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Proteins)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  6. depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden.

  7. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Proteins) activation and ROS (show ROS1 Proteins) production

  8. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Proteins)-expressing tumor in the transgenic mice.

  9. Engagement of Siglec-F induced mouse eosinophil apoptosis that was modest in magnitude and dependent on caspase (show CASP3 Proteins) activity.

  10. Siglec-9 (show SIGLEC9 Proteins) expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Proteins) and that this signaling may be another MUC1 (show MUC1 Proteins)-mediated pathway and function in parallel with a growth factor-dependent pathway.

SIGLEC5 Protein Profile

Protein Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene names and symbols associated with SIGLEC5

  • sialic acid binding Ig-like lectin 5 (SIGLEC5)
  • sialic acid binding Ig-like lectin 5 (Siglec5)
  • sialic acid binding Ig-like lectin E (Siglece)
  • CD33L2 protein
  • Cd170 protein
  • mSiglec-E protein
  • mSiglec-F protein
  • OB-BP2 protein
  • OBBP2 protein
  • SIGLEC-5 protein
  • Siglec5 protein
  • Siglec9 protein
  • Siglec12 protein
  • Siglecf protein
  • Siglecl1 protein

Protein level used designations for SIGLEC5

sialic acid binding Ig-like lectin 5 , CD33 antigen-like 2 , OB-binding protein 2 , obesity-binding protein 2 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding immunoglobulin-like lectin 5 , sialic acid binding Ig-like lectin F , sialic acid-binding Ig-like lectin F , sialic acid-binding lectin Siglec-F , siglec-5 , siglec-F , MIS , SIGLEC-like 1 , myeloid inhibitory siglec , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin E , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding immunoglobulin-like lectin E , siglec-12 , siglec-E , siglec-L1

GENE ID SPECIES
100597560 Nomascus leucogenys
8778 Homo sapiens
233186 Mus musculus
292843 Rattus norvegicus
83382 Mus musculus
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