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Sialic Acid Binding Ig-Like Lectin 9 Proteins (SIGLEC9)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping SIGLEC9 Antibodies (121) and SIGLEC9 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC9 27180 Q9Y336
Mouse SIGLEC9 SIGLEC9 83382 Q91Y57
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Top SIGLEC9 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Human Fc Tag   10 μg Log in to see 5 Days
$143.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

SIGLEC9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaction Partners

Chimpanzee Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) interaction partners

  1. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.

Human Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) interaction partners

  1. Ligands for Siglec-8 (show SIGLEC8 Proteins) and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  2. Inflammation results in up-regulation of immuneinhibitory Siglec-8 (show SIGLEC8 Proteins) and Siglec-9 sialoglycan ligands on human airways.

  3. a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung ca (show CD33 Proteins)ncer patients

  4. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3 (show CD33 Proteins).

  5. Expression of Siglec-7 (show SIGLEC7 Proteins) and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.

  6. Protein degradation of focal adhesion kinase and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells.

  7. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Proteins) and that this signaling may be another MUC1 (show MUC1 Proteins)-mediated pathway and function in parallel with a growth factor-dependent pathway.

  8. The Siglec-9 peptide binding to the enzymatic groove of VAP-1 (show AOC3 Proteins) can be used for imaging conditions, such as inflammation and cancer.

  9. Siglec-9 A391C was the only polymorphism related to TCR-mediated signaling in human Siglec-9, resulting in less inhibition compared to the wild type.

  10. These results suggest that Siglec-9 expressed on DCs is involved in immunoregulation through ligation with mucins in an epithelial cancer patient.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) interaction partners

  1. indicate that Siglec-9 affects several different signaling pathways in IL-4 (show IL4 Proteins)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Proteins) in Siglec-9-expressing RAW264 cells

  2. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Proteins) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  3. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Proteins)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Proteins)) interaction and endotoxemia.

  4. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Proteins)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  5. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Proteins) activation and ROS (show ROS1 Proteins) production

  6. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Proteins)-expressing tumor in the transgenic mice.

  7. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Proteins) and that this signaling may be another MUC1 (show MUC1 Proteins)-mediated pathway and function in parallel with a growth factor-dependent pathway.

  8. Siglec-E is induced in a MyD88 (show MYD88 Proteins)-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB (show NFKB1 Proteins) antiviral responses by directly inhibiting TLR-induced antiviral cytokine production.

SIGLEC9 Protein Profile

Protein Summary

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Gene names and symbols associated with SIGLEC9

  • sialic acid-binding immunoglobulin-like lectin 9 (siglec9)
  • sialic acid binding Ig-like lectin 9 (SIGLEC9)
  • sialic acid binding Ig-like lectin E (Siglece)
  • Cd170 protein
  • CD329 protein
  • CDw329 protein
  • FOAP-9 protein
  • mSiglec-E protein
  • OBBP-LIKE protein
  • siglec-9 protein
  • Siglec5 protein
  • Siglec9 protein
  • Siglec12 protein
  • Siglecl1 protein

Protein level used designations for SIGLEC9

sialic acid-binding immunoglobulin-like lectin 9 , sialic acid binding Ig-like lectin 9 , protein FOAP-9 , sialic acid-binding Ig-like lectin 9 , MIS , SIGLEC-like 1 , myeloid inhibitory siglec , sialic acid binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin E , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding immunoglobulin-like lectin E , siglec-12 , siglec-5 , siglec-E , siglec-L1

GENE ID SPECIES
497116 Pan troglodytes
100610476 Pan troglodytes
27180 Homo sapiens
83382 Mus musculus
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