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Sialidase 3 (Membrane Sialidase) Proteins (Neu3)

Neu3 product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Additionally we are shipping Neu3 Antibodies (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Neu3 50877 Q9JMH7
Neu3 10825  
Neu3 117185 Q99PW5
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Top Neu3 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,193.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Neu3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Sialidase 3 (Membrane Sialidase) (Neu3) Interaction Partners

Mouse (Murine) Sialidase 3 (Membrane Sialidase) (Neu3) interaction partners

  1. findings implicate NEU3 as a potential biomarker of insulin (show INS Proteins) sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression.

  2. NEU3 regulates the detergent resistant membrane ganglioside content.

  3. NEU3 up-regulation stimulates the EGF receptor (show EGFR Proteins) signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha (show HIF1A Proteins)), resulting in a final increase of cell survival and proliferation.

  4. NEU3 plays an important role in inflammation-dependent tumor development

  5. Data indicate that sialidases Neu1 (show NEURL Proteins) and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

  6. The work further supports the central role of NEU3 as a key modulator in skeletal muscle differentiation, particularly in the myoblast fusion step.

  7. NEU3 participates in the control of insulin (show INS Proteins) signaling via modulation of gangliosides and interaction with Grb2 (show GRB2 Proteins)

  8. NEU3 is able to mobilize to membrane ruffles in response to growth stimuli and activate the Rac-1 signaling by co-localization with Rac-1, leading to increased cell motility.

  9. Reduction of 70% of the plasma membrane-associated sialidase Neu3 activity caused neurite elongation in Neuro2a murine neuroblastoma (show ARHGEF16 Proteins) cells.

  10. findings suggest that the Neu3 gene represents a physiological modulator of VSMC responses that may contribute to plaque instability in atherosclerosis.

Human Sialidase 3 (Membrane Sialidase) (Neu3) interaction partners

  1. findings identify NEU3 as a participant in head and neck squamous cell carcinoma progression

  2. Besides the already reported indirect EGFR (show EGFR Proteins) activation through GM3 (show GRM6 Proteins), sialidase NEU3 could also play a role on EGFR (show EGFR Proteins) activation through its desialylation.

  3. NEU3 promotes anchorage-independent growth and in vivo tumorigenicity.

  4. In the plasma membrane, NEU3 has a role in endocytosis and protein binding at the cell surface.

  5. Results indicate an essential contribution of NEU3 to tumorigenic potential through maintenance of stem-like characteristics of colon cancer cells by regulating Wnt (show WNT2 Proteins) signaling at the receptor level.

  6. The results provide strong evidence that the serum sialidase is, in fact, NEU3, and this subtype may, therefore, be a potential utility for novel diagnosis of human cancers

  7. Studies indicate that ganglioside-specific sialidase NEU3 cleaves sialic acids preferentially from gangliosides.

  8. Weak anchorage of NEU1 (show NEU1 Proteins) and NEU3 to the plasma membrane and their loss during erythrocyte life could be a tool to preserve the cellular sialic acid content to avoid early aging of erythrocyte and processes of cell aggregation in the capillaries.

  9. NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK (show PTK2 Proteins)/AKT (show AKT1 Proteins) signaling and demonstrate its crucial role in renal cell carcinomas malignancy.

  10. Data indicate that sialidases Neu1 (show NEU1 Proteins) and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

Neu3 Protein Profile

Protein Summary

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.

Gene names and symbols associated with Neu3

  • sialidase 3 (membrane sialidase) (neu3)
  • neuraminidase 3 (Neu3)
  • sialidase 3 (membrane sialidase) (NEU3)
  • sialidase 3 (membrane sialidase) (Neu3)
  • SIAL3 protein

Protein level used designations for Neu3

N-acetyl-alpha-neuraminidase 3 , Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3) , ganglioside sialidase , membrane sialidase , sialidase-3 , neuraminidase 3

GENE ID SPECIES
100145410 Xenopus (Silurana) tropicalis
50877 Mus musculus
10825 Homo sapiens
117185 Rattus norvegicus
281349 Bos taurus
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