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The protein encoded by STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. Additionally we are shipping Signal Transducing Adaptor Family Member 1 Proteins (10) and many more products for this protein.
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STAP1 (show UXT Antibodies) associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
Mutations in STAP1 (show UXT Antibodies) are associated with autosomal dominant hypercholesterolemia.
Taken together, this study implicates a previously unknown role of STAP-1 in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration.
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
BCR downstream signaling 1
, signal transducing adaptor family member 1
, signal-transducing adaptor protein 1
, BCR downstream-signaling protein 1
, docking protein BRDG1
, signal-transducing adaptor protein-1
, stem cell adaptor protein 1
, stem cell adaptor protein STAP-1