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anti-Sirtuin 4 (SIRT4) Antibodies

SIRT4 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT4 Proteins (10) and SIRT4 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT4 23409 Q9Y6E7
SIRT4 75387 Q8R216
SIRT4 304539  
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Top anti-SIRT4 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit   Target Name: SIRT4   Sample Tissue: Human Fetal Liver  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185191 staining (1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Chicken Un-conjugated EIA, WB Western blot analysis of SIRT4 in human liver tissue lysate with SIRT4 antibody at 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (fro), IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB SIRT4 Antibody (N-term)  western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the SIRT4 antibody detected the SIRT4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with SIRT4 antibody ABIN337219 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details

SIRT4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIRT4 Antibodies

  1. Human Polyclonal SIRT4 Primary Antibody for IHC, ELISA - ABIN185191 : Frye: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 references for ABIN185191

  2. Cow (Bovine) Polyclonal SIRT4 Primary Antibody for EIA, IHC (p) - ABIN374409 : Ahuja, Schwer, Carobbio, Waltregny, North, Castronovo, Maechler, Verdin: Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN374409

  3. Human Polyclonal SIRT4 Primary Antibody for EIA, WB - ABIN783612 : Salminen, Kaarniranta: SIRT1: regulation of longevity via autophagy. in Cellular signalling 2009 (PubMed)
    Show all 2 references for ABIN783612

  4. Human Polyclonal SIRT4 Primary Antibody for IHC (fro), IF (p) - ABIN872709 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. in Acta oto-laryngologica 2014 (PubMed)

More Antibodies against SIRT4 Interaction Partners

Human Sirtuin 4 (SIRT4) interaction partners

  1. Thus, these results suggest that SIRT4 has essential roles in stress resistance and may be an important therapeutic target for cancer treatment.

  2. SIRT4 behaves as a tumor suppressor at the human tissue protein level.

  3. Overexpression of SIRT4 attenuated inflammation mediators in umbilical vein endothelial cells.

  4. Results show that mitochondrial sirtuins SIRT3 (show SIRT3 Antibodies), SIRT4, and SIRT5 (show SIRT5 Antibodies) can promote increased mitochondrial respiration and cellular metabolism and respond to excess glucose by inducing a coordinated increase of glycolysis and respiration.

  5. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer.

  6. Serum Sirt4 was inversely related to anthropometric and metabolic parameters and positively related to peak GH and IGF-1 (show IGF1 Antibodies).

  7. C-terminal-binding protein (CtBP (show CTBP2 Antibodies)) was found to have an essential role in promoting glutaminolysis by directly repressing the expression of SIRT4.

  8. This study demonstrated that SIRT4 upregulation in the liver of non-alcoholic fatty liver disease patients.

  9. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (show PDP Antibodies) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

  10. The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease.

Mouse (Murine) Sirtuin 4 (SIRT4) interaction partners

  1. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (show PDP Antibodies) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

  2. The results of this study indicated a critical and novel stress response role for SIRT4 in promoting proper glutamate (show GRIN1 Antibodies) transport capacity and protecting against excitotoxicity

  3. regulates ATP levels via ANT2 (show SLC25A5 Antibodies) and a feedback loop involving AMPK (show PRKAA1 Antibodies)

  4. these results highlight the tumor-suppressive role of SIRT4 in Myc (show MYC Antibodies)-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc (show MYC Antibodies)-induced and/or glutamine (show GFPT1 Antibodies)-dependent cancers.

  5. The enhanced fatty acid oxidation observed in SIRT4 knockout hepatocytes requires functional SIRT1 (show SIRT1 Antibodies), demonstrating a clear cross talk between mitochondrial and nuclear sirtuins.

  6. Data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine (show GFPT1 Antibodies) metabolism, cell cycle arrest, and tumor suppression.

  7. SIRT4 represses fatty acid oxidation and stimulates lipogenesis. SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.

  8. Data demonstrate that SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle.

  9. controls insulin secretion in pancreatic beta cells; also transfers an ADP-ribosyl group from NAD to histones

  10. NAD analogues and 32P-NAD were used to study the ADP-ribosyltransferase activity of several different sirtuins, including yeast Sir2 (show SIRT1 Antibodies), human SirT1 (show SIRT1 Antibodies), mouse SirT4, and mouse SirT6 (show SIRT6 Antibodies).

SIRT4 Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Gene names and symbols associated with anti-Sirtuin 4 (SIRT4) Antibodies

  • sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) (SIRT4) antibody
  • zgc:103539 (zgc:103539) antibody
  • sirtuin 4 (SIRT4) antibody
  • sirtuin 4 (Sirt4) antibody
  • 4930596O17Rik antibody
  • im:7139453 antibody
  • SIR2L4 antibody
  • SIRT4 antibody

Protein level used designations for anti-Sirtuin 4 (SIRT4) Antibodies

sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin 4 , NAD-dependent ADP-ribosyltransferase sirtuin-4 , NAD-dependent protein deacetylase sirtuin-4 , SIR2-like protein 4 , regulatory protein SIR2 homolog 4 , sir2-like 4 , sirtuin type 4 , NAD-dependent deacetylase sirtuin-4

GENE ID SPECIES
742235 Pan troglodytes
791628 Danio rerio
100586803 Nomascus leucogenys
23409 Homo sapiens
75387 Mus musculus
304539 Rattus norvegicus
477507 Canis lupus familiaris
100125349 Sus scrofa
519328 Bos taurus
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