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anti-Sirtuin 5 (SIRT5) Antibodies

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 5 Proteins (21) and Sirtuin 5 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Top anti-Sirtuin 5 Antibodies at antibodies-online.com

Showing 10 out of 168 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT5 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SIRT5  Antibody Titration: 5.0 µg/mL ELISA Titer: 1:.2500  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT5 Antibody Titration: 1.0-2.0ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of anti-SIRT5 Pab (ABIN390180) in Jurkat cell line lysate (35 µg/lane). SIRT5(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Chicken Un-conjugated EIA, WB Western blot analysis of SIRT5 in human liver tissue lysate with SIRT5 antibody at 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (fro), IF (p), IHC (p), WB Mouse splenocytes probed with Rabbit Anti-SIRT5 Polyclonal Antibody, Unconjugated . 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC200189 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-SIRT5 antibody (ABIN2454823), and then analyzed by flow cytometry. Anti-SIRT5 mouse monoclonal antibody (ABIN2454823) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SIRT5 (RC200189). 100 μL Log in to see 2 to 3 Days
$423.50
Details

SIRT5 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Sirtuin 5 Antibodies

  1. Human Polyclonal SIRT5 Primary Antibody for EIA, WB - ABIN783614 : Salminen, Kaarniranta: SIRT1: regulation of longevity via autophagy. in Cellular signalling 2009 (PubMed)
    Show all 2 references for ABIN783614

  2. Human Polyclonal SIRT5 Primary Antibody for EIA, IHC (p) - ABIN358734 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 2 references for ABIN358734

  3. Human Polyclonal SIRT5 Primary Antibody for IHC (fro), IF (p) - ABIN1387080 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. in Acta oto-laryngologica 2014 (PubMed)

  4. Human Polyclonal SIRT5 Primary Antibody for IHC (p), WB - ABIN390180 : Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. in BMC cancer 2014 (PubMed)

  5. Cow (Bovine) Polyclonal SIRT5 Primary Antibody for IHC, WB - ABIN2778620 : Chowdari, Northup, Pless, Wood, Joo, Mirnics, Lewis, Levitt, Bacanu, Nimgaonkar: DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia. in Genes, brain, and behavior 2007 (PubMed)

  6. Chicken Polyclonal SIRT5 Primary Antibody for WB - ABIN2778619 : Mahlknecht, Ho, Letzel, Voelter-Mahlknecht: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. in Cytogenetic and genome research 2006 (PubMed)

More Antibodies against Sirtuin 5 Interaction Partners

Human Sirtuin 5 (SIRT5) interaction partners

  1. Use of a pan (show SUPT6H Antibodies)-sirtuin (show SIRT1 Antibodies) inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 (show SIRT2 Antibodies) and SIRT5, in the regulation of the necroptotic cell death program

  2. mutual cooperation between Y102 and R105 residues in promoting the desuccinylation versus deacetylation reaction in SIRT5.

  3. Data showed that SIRT5 was involved in protein post-translational modifications through its potent demalonylase, desuccinylase, and deglutarylase activities. Also, the protein was found in the mitochondrial, cytoplasmic, and nuclear compartments. [review]

  4. Results show that mitochondrial sirtuins SIRT3 (show SIRT3 Antibodies), SIRT4 (show SIRT4 Antibodies), and SIRT5 can promote increased mitochondrial respiration and cellular metabolism and respond to excess glucose by inducing a coordinated increase of glycolysis and respiration.

  5. Results suggest a role for SIRT5 in influencing oocyte quality and in vitro fertilization outcomes.

  6. SIRT1 (show SIRT1 Antibodies)/SIRT5-mediated PML (show PML Antibodies) deacetylation plays a role in the regulation of cancer cell survival.

  7. The results reveal the Sirt5 substrate acyl selectivity and its molecular basis and enable the design of inhibitors for Sirt5.

  8. High SIRT5 expression facilitates cancer cell growth and drug resistance in non-small cell lung cancer.

  9. Expression of SIRT5 in the entorhinal cortex, hippocampus, and white matter increases during the progression of Alzheimer disease. It is seen in activated microglia.

  10. These results reveal a novel post-translational regulation of SOD1 (show SOD1 Antibodies) by means of succinylation and SIRT5-dependent desuccinylation, which is important for the growth of lung tumor cells.

Cow (Bovine) Sirtuin 5 (SIRT5) interaction partners

  1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Mouse (Murine) Sirtuin 5 (SIRT5) interaction partners

  1. In the cochlea, the expression of SIRT1 (show SIRT1 Antibodies), 3, and 5 (both mRNA and protein) was decreased in the old mice

  2. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  3. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (show SDHA Antibodies)), implicating alteration in SDH (show SDS Antibodies) activity as causative of the injury.

  4. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

  5. SIRT3 (show SIRT3 Antibodies) and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase (show ACADVL Antibodies)

  6. Pathway analysis identified glycolysis as the top SIRT5-regulated pathway. Importantly, glycolytic flux was diminished in primary hepatocytes from Sirt5(-/-) compared to WT mice.

  7. Data indicated that SIRT5 ameliorates MPTP (show PTPN2 Antibodies)-induced nigrostriatal dopaminergic degeneration via preserving mitochondrial antioxidant capacity.

  8. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

  9. Loss of SIRT5 leads to accumulation of medium- and long-chain acylcarnitines and decreased beta-hydroxybutyrate production in vivo.

  10. Sirt5 is likely to be dispensable for the metabolic homeostasis under the basal conditions.

Sirtuin 5 (SIRT5) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 5 (SIRT5) Antibodies

  • sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) (SIRT5) antibody
  • sirtuin 5 (CC1G_00083) antibody
  • sirtuin 5 (sirt5) antibody
  • sirtuin 5 (SIRT5) antibody
  • sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) (sirt5) antibody
  • sirtuin 5 (Sirt5) antibody
  • 0610012J09Rik antibody
  • 1500032M05Rik antibody
  • AV001953 antibody
  • SIR2L5 antibody
  • SIRT5 antibody
  • sirt5-a antibody
  • zgc:92288 antibody

Protein level used designations for anti-Sirtuin 5 (SIRT5) Antibodies

sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , regulatory protein SIR2 homolog 5 , sirtuin (silent mating type information regulation 2 homolog) 5 , NAD-dependent deacetylase sirtuin-5 , SIR2-like protein 5 , nad-dependent deacetylase sirtuin-5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , Regulatory protein SIR2 homolog 5

GENE ID SPECIES
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
436878 Danio rerio
23408 Homo sapiens
496346 Xenopus laevis
420834 Gallus gallus
478726 Canis lupus familiaris
100125966 Sus scrofa
507347 Bos taurus
68346 Mus musculus
306840 Rattus norvegicus
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