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The protein encoded by SLIT3 is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Additionally we are shipping SLIT3 Kits (4) and SLIT3 Proteins (3) and many more products for this protein.
Showing 10 out of 43 products:
Cow (Bovine) Polyclonal SLIT3 Primary Antibody for EIA, WB - ABIN401312
Itoh, Miyabayashi, Ohno, Sakano: Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. in Brain research. Molecular brain research 1999
Show all 4 references for ABIN401312
Human Polyclonal SLIT3 Primary Antibody for WB - ABIN2787819
Lin, Isacson: Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. in Stem cells (Dayton, Ohio) 2006
Slit3 (and slit-2 (show SLIT2 Antibodies)) coordinate neuron axonal pathfinding within the embryonic axon tracts along with Robo2 (show ROBO2 Antibodies) and Dcc (show DCC Antibodies)-Netrin1.
Data show that Hedgehog (show SHH Antibodies) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2 (show SLIT2 Antibodies), slit3 and sema3d (show SEMA3D Antibodies).
Overexpression of Slit3 (show SLIT1 Antibodies) induces its tumor suppressive effects in Breast cancer.
Results show that silencing of Slit3 (show SLIT1 Antibodies) promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 (show SLIT1 Antibodies) functions as a tumor suppressor in lung carcinoma.
Estrogen-dependent expression of SLIT3 (show SLIT1 Antibodies) may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions.
SLIT3 (show SLIT1 Antibodies) is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 (show SLIT1 Antibodies) in these tissues.
High SLIT3 (show SLIT1 Antibodies) expression is associated with high-grade gliomas.
SLIT3 (show SLIT1 Antibodies)-ROBO4 (show ROBO4 Antibodies) activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.
results implicate the involvement of miR (show MLXIP Antibodies)-218-2 and its host gene SLIT3 (show SLIT1 Antibodies) in thyroid cancer cell invasion, migration, and proliferation
Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo.
three major members (Slit2/3 and Robo1 (show ROBO1 Antibodies)) of Slit/Robo family are widely expressed in the human normal and malignant ovarian tissues; but Slit/Robo signaling may not play an important role in regulating human ovarian cancer cell proliferation and migration
SLIT3 (show SLIT1 Antibodies) duplication on 5q35.1 predisposes to major depressive disorder
In mice with oxygen-induced retinopathy (OIR), the expression level of miR-218 was significantly downregulated. Robo1 expression was suppressed by miR-218. Furthermore, in the mice with OIR, the expression level of miR-218 was significantly downregulated, and that of miR-218-1 and its host gene, Slit2, was concomitantly downregulated as well.
Heparan sulfate-deficient mouse endothelial cells was used to determine the co-reception function of heparan sulfate in Slit3-induced endothelial cell migration.
FREM1 (show FREM1 Antibodies)-deficient mice faithfully recapitulate many of the phenotypes seen in individuals with FREM1 (show FREM1 Antibodies) deficiency and that variations in GATA4 (show GATA4 Antibodies) and SLIT3 expression modulate some FREM1 (show FREM1 Antibodies)-related phenotypes in mice.
Report role of Slit3 in development of the caval veins and pericardium.
Robo-2 (show ROBO2 Antibodies)-mediated targeting of P2 axons along the dorsoventral axis of the OB is controlled by Slit-3 expression
Study identify that the homeobox (show PRRX1 Antibodies) gene Nkx2-5 (show NKX2-5 Antibodies) is required for early ventral restriction of Slit3 and that the T-box transcription factor Tbx2 (show TBX2 Antibodies) mediates repression of Slit3 in nonchamber myocardium.
The chemorepellent Slit3 promotes monocyte migration.
During blood vessel development, Slit3 gene expression (and that of Slit2) are linked to posttranscriptional regulation of Robo receptors.
Data suggest that the Slit family of axon guidance molecules (Slit 1 (show SLIT1 Antibodies)-3) and their Robo 1 (show ROBO1 Antibodies) and 2 receptors contribute to the topographic targeting of basal vomeronasal axons.
Experiments with triple mutant mice demonstrate a key role for Slit3 signaling in vertebrate midline commissural axon guidance.
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene.
slit homolog 3
, slit homolog 3 protein
, slit homolog 3 (Drosophila)
, slit homolog 3 protein-like
, multiple EGF-like domains protein 5
, multiple epidermal growth factor-like domains protein 5
, multiple epidermal growth factor-like domains 5