anti-Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG6) Antibodies

SMG6 encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of SMG6 also participates in the nonsense-mediated mRNA decay (NMD) pathway. Additionally we are shipping SMG6 Kits (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SMG6 SMG6 103677 P61406
SMG6 23293 Q86US8
SMG6    
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Top anti-SMG6 Antibodies at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using SMG6 antibody. 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: SMG6 Antibody [NBP1-92410] - Staining of human cerebellum shows distinct cytoplasmic and nucleolar/ nuclear positivity in Purkinje cells. Immunocytochemistry/Immunofluorescence: SMG6 Antibody [NBP1-92410] Staining of human cell line U-2 OS shows positivity in nucleus, nucleoli & cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p)   100 μL Log in to see 11 to 12 Days
$420.00
Details
Human Rabbit Un-conjugated   100 μg Log in to see 11 to 16 Days
$391.88
Details

SMG6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,


Rat (Rattus)


More Antibodies against SMG6 Interaction Partners

Mouse (Murine) Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG6) interaction partners

  1. Smg6/Est1 (show AP1S2 Antibodies) licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.

Human Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG6) interaction partners

  1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture.

  2. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.

  3. A preferred sequence motif spanning most SMG6 cleavage sites has been discovered by analysis of endogenous non-sense-mediated mRNA decay targets.

  4. SMG6 requires UPF1 (show UPF1 Antibodies) and SMG1 (show SMG1 Antibodies) for nonsense-mediated mRNA decay.

  5. The study demonstrates that SMG5 (show SMG5 Antibodies)-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 (show UPF1 Antibodies) recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.

  6. Consistent with involvement of SMG6 in the decay process full-length nonsense-containing beta-globin (show HBB Antibodies) mRNA was increased and the Delta169 decay intermediate was decreased in cells knocked down for SMG6.

  7. The tricotetrapeptide repeat-containing domain within Est1A was sufficient for interaction with hTERT.

  8. Data show that SMG6 interacts directly with the EJC via two conserved EJC-binding motifs (EBMs).

  9. Human EST1A is associated with most or all active telomerase and is involved either directly or indirectly in telomere elongation and telomere capping.

  10. Structural properties of the PIN (show DYNLL1 Antibodies) domain indicate its putative active center consisting of invariant acidic amino acid residues, which is similar to the active center of 5' nucleases.

SMG6 Antigen Profile

Protein Summary

This gene encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC)\; interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMG6

  • Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg6) antibody
  • SMG6, nonsense mediated mRNA decay factor (SMG6) antibody
  • AI317223 antibody
  • AU041178 antibody
  • C17orf31 antibody
  • EST1A antibody
  • hSMG5/7a antibody
  • SMG-6 antibody

Protein level used designations for SMG6

EST1-like protein A , ever shorter telomeres 1A , telomerase subunit EST1A , telomerase-binding protein EST1A , EST1 telomerase component homolog A , smg-6 homolog, nonsense mediated mRNA decay factor

GENE ID SPECIES
103677 Mus musculus
100172632 Pongo abelii
23293 Homo sapiens
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