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Snail Homolog 1 (Drosophila) Proteins (SNAI1)

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. Additionally we are shipping Snail Homolog 1 (Drosophila) Antibodies (145) and Snail Homolog 1 (Drosophila) Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNAI1 6615 O95863
Rat SNAI1 SNAI1 116490  
SNAI1 20613 Q02085
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Top Snail Homolog 1 (Drosophila) Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days

SNAI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Snail Homolog 1 (Drosophila) (SNAI1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Snail Homolog 1 (Drosophila) (SNAI1) interaction partners

  1. evidence for mechanosensitivity of cell-cell junctions and implications that myosin-mediated tension can prevent Snail-driven Eepithelial-mesenchymal transitions

  2. Snail can potentiate enhancer activation by collaborating with different activators, providing a new mechanism by which Snail regulates development.

  3. Rapid transcription kinetics and negative autoregulation are responsible for the remarkable homogeneity of snail expression and the coordination of mesoderm invagination.

  4. Study shows that Sna represses transcription of pbl in the mesoderm primordium of D. melanogaster via one or more Sna-binding sites, which are conserved among species of the Drosophila genus, but not in the mosquito, correlating with the different modes of gastrulation in the different genuses.

  5. Complex interactions between cis (show CISH Proteins)-regulatory modules in native conformation are critical for Drosophila snail expression.

  6. The Snail repressor positions Notch (show NOTCH1 Proteins) signaling in the Drosophila embryo.

  7. results show that Sna has a positive regulatory function on sim (show SIM2 Proteins) expression in the presumptive mesectoderm; this positive effect of Sna depends on the Su(H (show RBPJ Proteins))-binding sites within the sim (show SIM2 Proteins) promoter, suggesting that Sna regulates Notch (show NOTCH1 Proteins) signaling

  8. snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.

  9. Dorsal activates twist and snail, and the Dorsal/Twist/Snail network activates and represses other zygotic genes to form the dorsoventral axis in Drosophila.

  10. Snail represses Tom expression in the mesoderm and thereby activates Delta trafficking.

Xenopus laevis Snail Homolog 1 (Drosophila) (SNAI1) interaction partners

  1. The transcription factor Snail1 is essential for tissue separation, enabling paraxial protocadherin (PAPC (show PCDH8 Proteins)) to promote tissue separation through novel functions.

  2. Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.

  3. the same E3 ubiquitin ligase (show MUL1 Proteins) known to regulate Snail family proteins, Partner of paired (Ppa (show FBXL14 Proteins)), also controlled Twist stability and did so in a manner dependent on the Twist WR-rich domain

Human Snail Homolog 1 (Drosophila) (SNAI1) interaction partners

  1. JianPi JieDu Recipe could inhibit TGF-beta (show TGFB1 Proteins)-induced epithelial-to-mesenchymal transition in colorectal cancer through TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) mediated Snail/E-cadherin (show CDH1 Proteins) expression

  2. Treatment of these cells with the dual-specificity tyrosine-kinase (show TXK Proteins) inhibitor lapatinib led to downregulation of epithelial-to-mesenchymal transition as indicated by lower levels of SNAI1 and SNAI2 (show SNAI2 Proteins) transcripts, integrin AVB6, and matrix metalloproteinase 9 (show MMP9 Proteins) protein

  3. the present study suggests that GAPDH (show GAPDH Proteins) plays an important role in cancer metastasis by affecting EMT (show ITK Proteins) through regulation of Sp1 (show PSG1 Proteins)-mediated SNAIL expression.

  4. the expression of CCL2 (show CCL2 Proteins) is significantly correlated with Snail expression and may be used as a predictive co-biomarker for patient prognosis and tumor aggressiveness in gastric cancer.

  5. High Snail1 expression is associated with Recurrence of Prostate Cancer.

  6. Our findings implicate Snail as a target for the prevention of fibrogenesis or fibrosis progression and may offer a means to assess response to therapy.

  7. Snail overexpression induced epithelial-mesenchymal transition and endowed cells with tumor stem cell characteristics.

  8. Upregulation of SNAIL1 promotes prostate cancer.

  9. Snail and N-cadherin (show CDH2 Proteins) are constitutively and inducibly expressed in papillary thyroid carcinoma

  10. Radixin (show RDX Proteins) knockdown suppresses the metastasis of SGC (show SGCB Proteins)-7901 cells in vitro by up-regulation of E-cadherin (show CDH1 Proteins). The NF-kappaB (show NFKB1 Proteins)/snail pathway contributes to the regulation of E-cadherin (show CDH1 Proteins) in response to depletion of radixin (show RDX Proteins).

Mouse (Murine) Snail Homolog 1 (Drosophila) (SNAI1) interaction partners

  1. Snail1 deficiency modified the phenotype of pancreatic tumors .

  2. miR (show MLXIP Proteins)-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes, such as Smad2 (show SMAD2 Proteins) and Smad5 (show SMAD5 Proteins).

  3. show that Snail1-induced fibrosis can be reversed in vivo and that obstructive nephropathy can be therapeutically ameliorated in mice by targeting Snail1 expression

  4. Results suggest that Snai1 is a key factor that triggers ESCs (show NR2E3 Proteins) exit from the pluripotency state and initiate their differentiation processes.

  5. During embryonic stem cell differentiation, an endogenous Wnt (show WNT2 Proteins)-mediated burst in Snail1 expression regulates neuroectodermal fate while playing a role in epiblast stem cell exit and the consequent lineage fate decisions that define mesoderm commitment.

  6. The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life.

  7. Snail inhibits adipogenesis through a down-regulation of Nr2f6 (show NR2F6 Proteins), which in turn facilitates the expression of IL-17 (show IL17A Proteins), an anti-adipogenic cytokine.

  8. Snail1 acts as a VEGF (show VEGFA Proteins)-induced regulator of Notch1 (show NOTCH1 Proteins) signalling and Dll4 (show DLL4 Proteins) expression. Results document a Snail1-Dll4 (show DLL4 Proteins)/Notch1 (show NOTCH1 Proteins) axis that controls embryonic vascular development.

  9. Cav1 (show CAV1 Proteins) knockout promotes MEK (show MDK Proteins)-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis.

  10. overexpression of Snail in PDAC cells increased SCF (show KITLG Proteins) levels, and the media conditioned by Snail-expressing PDAC cells promoted mast cell migration.

Snail Homolog 1 (Drosophila) (SNAI1) Protein Profile

Protein Summary

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.

Gene names and symbols associated with SNAI1

  • snail homolog 1 (Drosophila) (SNAI1)
  • snail 1 homolog (LOC100350709)
  • snail 1 homolog (LOC100352102)
  • snail (sna)
  • zinc-finger transcription factor Snail (snail)
  • snail family zinc finger 1 (snai1)
  • snail protein (Snail)
  • transcription factor protein (snail)
  • snail zinc finger protein (snail)
  • snail family zinc finger 1 (SNAI1)
  • snail family zinc finger 1 (Snai1)
  • snail homolog 1 (Drosophila) (Snai1)
  • AI194338 protein
  • BG:DS01845.1 protein
  • br28 protein
  • br29 protein
  • CG3956 protein
  • dJ710H13.1 protein
  • Dmel\\CG3956 protein
  • l(2)35Db protein
  • l(2)br28 protein
  • l(2)br29 protein
  • l(3)br28 protein
  • l35Db protein
  • Sco protein
  • SLUGH2 protein
  • sn protein
  • sna protein
  • Sna1 protein
  • SNAH protein
  • Snai protein
  • SNAI1 protein
  • Snail protein
  • Snail1 protein
  • xSna protein
  • Xsnail protein

Protein level used designations for SNAI1

snail homolog 1 , snail like protein , Protein snail-like protein 1 , snail homolog 1 (Drosophila) , snail 1 homolog , CG3956-PA , scutoid , sna-PA , zinc-finger transcription factor Snail , protein Xsnail , protein snail homolog Sna , protein xSna , snail protein , zinc finger protein with snail domain similar to escargot , transcription factor protein , snail zinc finger protein , snail-like protein 1 , protein sna , protein snail homolog 1 , snail 1 zinc finger protein , snail 1, zinc finger protein , zinc finger protein SNAI1

396047 Gallus gallus
702353 Macaca mulatta
745644 Pan troglodytes
100127224 Ovis aries
100350709 Oryctolagus cuniculus
100352102 Oryctolagus cuniculus
34908 Drosophila melanogaster
378469 Strongylocentrotus purpuratus
379615 Xenopus laevis
410464 Apis mellifera
778762 Ciona intestinalis
100303552 Saccoglossus kowalevskii
100029017 Monodelphis domestica
6615 Homo sapiens
116490 Rattus norvegicus
20613 Mus musculus
485924 Canis lupus familiaris
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