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Sodium Channel, Voltage-Gated, Type IX, alpha Subunit Proteins (SCN9A)

SCN9A encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Additionally we are shipping SCN9A Antibodies (95) and SCN9A Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCN9A 20274  
Rat SCN9A SCN9A 78956 O08562
SCN9A 6335 Q15858
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Top SCN9A Proteins at antibodies-online.com

Showing 3 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SCN9A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaction Partners

Cow (Bovine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. TNF-alpha (show TNF Proteins) up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha (show TNF Proteins)

  2. Findings suggest that the endothelin-1 (show EDN1 Proteins)-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau.

  3. Nav1.7-Ca2 (show CA2 Proteins)+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK (show MAPK1 Proteins)) and p38 (show MAPK14 Proteins) attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK (show MAPK1 Proteins) and p38 (show MAPK14 Proteins)

  4. constitutively phosphorylated/activated ERK (show MAPK1 Proteins) destabilizes Na(+) channel alpha-subunit (show POLG Proteins) mRNA via translational event, which negatively regulates steady-state level of alpha-subunit (show POLG Proteins) mRNA and cell surface expression of functional Na(+) channels.

  5. Na influx via scn9a converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (show PENK Proteins) mRNA and met-enkephalin protein in sensory neurons.

  2. Global Nav1.7 knockouts showed no defects in mechanical sensitivity or overall movement yet were completely insensitive to painful tactile, thermal, and chemical stimuli and were anosmic.

  3. Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability.

  4. a novel regulatory mechanism that utilizes CRMP2 (show DPYSL2 Proteins) SUMOylation to choreograph NaV1.7 trafficking.

  5. Behavioural deficits in Nav1.7/Nav1.8 (show SCN10A Proteins) knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  6. Deleting SCN9A in both sensory and sympathetic neurons abolishes pain sensations.

  7. These results demonstrate increased expression levels of Nav1.7, Nav1.8 (show SCN10A Proteins), and perhaps Nav1.1 (show SCN1A Proteins) in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (show NF1 Proteins) gene

  8. Nav1.7 is the dominant sodium channel in rat and mouse olfactory sensory neurons.

  9. examined the function of Na(v)1.7 (PN1) in pain pathways [Na(v)1.7]

  10. contrast to the highly significant role for Nav1.7 in determining inflammatory pain thresholds, the development of neuropathic pain does not require the presence of either Nav1.7 or Nav1.8 (show SCN10A Proteins) alone or in combination

Human Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. Postoperative pain was affected by SCN9A genetic variability in gynecological surgical patients.

  2. Patients with the SCN9A mutation with inherited erythromelalgia were characterized for the pain phenotype among individuals.

  3. These findings provided evidence that the variability of basal pain sensitivity was associated with SCN9A polymorphisms in the general population.

  4. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (show PENK Proteins) mRNA and met-enkephalin protein in sensory neurons.

  5. Association of SCN9A variants with neuropathic pain and pain severity suggests a role of SCN9A in the disease etiology of neuropathic pain

  6. We report the case of a 6-year-old girl with a SCN9A mutation who presented with both gain of function and loss of function phenotypes, including congenital corneal anesthesia.

  7. the activity of mutant Nav1.7 channels in smooth muscle cells of skin vasculature and innervating sensory and sympathetic fibers contribute to the skin reddening

  8. Novel SCN9A mutations altering Nav1.7 channel activation were found families with inherited erythromelalgia, paroxysmal extreme pain disorder and congenital insensitivity to pain.

  9. NaV1.7 is expressed in both dorsal root ganglion neurons and pancreatic beta cells.Vulnerability of dorsal root ganglia neurons due to NaV1.7 mutations increases risk of neuropathy.

  10. Our study demonstrates an example of predicting the treatment effect of mexiletine in patients suffering from a specific gain-of-function mutation in NaV1.7

SCN9A Protein Profile

Protein Summary

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.

Gene names and symbols associated with SCN9A

  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A)
  • sodium channel, voltage-gated, type IX, alpha (Scn9a)
  • DKFZp459G084 protein
  • ETHA protein
  • FEB3B protein
  • GEFSP7 protein
  • mKIAA4197 protein
  • Nav1.7 protein
  • NE-NA protein
  • NENA protein
  • PN1 protein
  • Scn2a protein
  • SCN9A protein
  • SFNP protein

Protein level used designations for SCN9A

sodium channel, voltage-gated, type IX, alpha subunit , sodium channel protein type 9 subunit alpha-like , peripheral sodium channel 1 , sodium channel 25 , sodium channel protein type 9 subunit alpha , sodium channel protein type IX subunit alpha , sodium channel, voltage-gated, type IX, alpha polypeptide , voltage-gated sodium channel alpha subunit Nav1.7 , voltage-gated sodium channel subunit alpha Nav1.7 , sodium channel, voltage-gated, type 9, alpha polypeptide , hNE-Na , neuroendocrine sodium channel , nas , schwann cell sodium channel , sodium channel alpha-subunit

GENE ID SPECIES
488381 Canis lupus familiaris
533065 Bos taurus
100016648 Monodelphis domestica
100172961 Pongo abelii
100385702 Callithrix jacchus
100482886 Ailuropoda melanoleuca
100516701 Sus scrofa
100583836 Nomascus leucogenys
20274 Mus musculus
78956 Rattus norvegicus
6335 Homo sapiens
100009210 Oryctolagus cuniculus
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