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Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 Proteins (SLC12A7)

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. Additionally we are shipping SLC12A7 Antibodies (64) and SLC12A7 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC12A7 10723 Q9Y666
SLC12A7 308069 Q5RK27
SLC12A7 20499 Q9WVL3
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Top SLC12A7 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Rat His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details

SLC12A7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) interaction partners

  1. SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis.

  2. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Proteins)/2 and NCC (show SLC12A3 Proteins) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  3. KCC3 (show SLC12A6 Proteins) is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Proteins) and KCC4 that could result in modulation of KCC activity

  4. Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 (show AQP1 Proteins) water channel (show AQP4 Proteins), revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly.

  5. analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 (show SLC12A5 Proteins) and KCC4

  6. KCC activation by IGF-1 (show IGF1 Proteins) plays an important role in IGF-1 (show IGF1 Proteins) signaling to promote growth and spread of gynecological cancers.

  7. Among patients with early-stage node-negative breast cancer, disease-free survival (DFS (show FST Proteins)) and overall survival (OS) curves were significantly different based on IGF-1 (show IGF1 Proteins) and KCC expression.

  8. KCC4 and H+,K+-ATPase (show ATP1A1 Proteins) are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.

  9. In the metastatic cancer tissues, KCC4 colocalizes with IGF-I (show IGF1 Proteins) or EGF (show EGF Proteins).

  10. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) interaction partners

  1. Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct.

  2. We propose that glycosylation is essential for the surface expression, stabilization, and bioactivity of KCC4

  3. KCC3 (show SLC12A6 Proteins) is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Proteins) and KCC4 that could result in modulation of KCC activity

  4. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.

  5. Ste20 (show STK24 Proteins)-related proline-alanine-rich kinase (SPAK (show STK39 Proteins)) and oxidative stress response 1 (OSR1 (show OSR1 Proteins)) with the cotransporters KCC3 (show SLC12A6 Proteins), NKCC1 (show SLC12A2 Proteins), and NKCC2 (show SLC12A1 Proteins) but not KCC1 (show SLC12A4 Proteins) and KCC4

  6. all of the CCCs examined (NKCC1 (show SLC12A2 Proteins), NKCC2 (show SLC12A1 Proteins), KCC1 (show SLC12A4 Proteins), KCC3 (show SLC12A6 Proteins), and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site

  7. KCC4 and H+,K+-ATPase (show ATP1A1 Proteins) are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.

SLC12A7 Protein Profile

Protein Summary

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

Gene names and symbols associated with SLC12A7

  • solute carrier family 12 (potassium/chloride transporters), member 7 (SLC12A7)
  • solute carrier family 12 (potassium/chloride transporter), member 7 (SLC12A7)
  • solute carrier family 12 (potassium/chloride transporter), member 7 (Slc12a7)
  • solute carrier family 12, member 7 (Slc12a7)
  • AA408796 protein
  • D13Ertd261e protein
  • Kcc4 protein
  • Slc12a5 protein
  • SLC12A7 protein

Protein level used designations for SLC12A7

solute carrier family 12 (potassium/chloride transporters), member 7 , K-Cl cotransporter 4 , electroneutral potassium-chloride cotransporter 4 , potassium/chloride transporter KCC4 , solute carrier family 12 member 7 , K-Cl cotransporter KCC4 , furosemide-sensitive KCl cotransporter 4 , potassium-chloride cotransporter

GENE ID SPECIES
528038 Bos taurus
709581 Macaca mulatta
10723 Homo sapiens
308069 Rattus norvegicus
100008847 Oryctolagus cuniculus
20499 Mus musculus
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