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SLC12A4 encodes a member of the SLC12A transporter family. Additionally we are shipping Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 Antibodies (42) and many more products for this protein.
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Results show that zebrafish little ears (lte) mutations correspond to lesions in Nkcc1 (show SLC12A2 Proteins).
The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Proteins)/2 and NCC (show SLC12A3 Proteins) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
Insulin (show INS Proteins)-like growth factors I can induce the upregulation of KCC1 gene, and KCC1 gene participates in the invasion ability of HEC (show NDC80 Proteins)-1B cells through the ERK (show EPHB2 Proteins) signaling pathway.
KCC3 (show SLC12A6 Proteins) is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 (show SLC12A7 Proteins) that could result in modulation of KCC activity
the KCC1 gene promoter lacks a TATA box and is composed of an initiator element (InR (show INSR Proteins)) and a downstream promoter element (DPE)
KCC activation by IGF-1 (show IGF1 Proteins) plays an important role in IGF-1 (show IGF1 Proteins) signaling to promote growth and spread of gynecological cancers.
IGF-II (insulin-like growth factors-2) can enhance KCC1 (KC1 co-transport-1) gene expression in cervical cancer cells through signal transduction pathways
We show that a single mutant allele of Kcc1 induces widespread sickling and tissue damage, leading to premature death in a humanized mouse model of sickle cell disease
Ste20 (show STK24 Proteins)-related proline-alanine-rich kinase (SPAK (show STK39 Proteins)) and oxidative stress response 1 (OSR1 (show OSR1 Proteins)) with the cotransporters KCC3 (show SLC12A6 Proteins), NKCC1 (show SLC12A2 Proteins), and NKCC2 (show SLC12A1 Proteins) but not KCC1 and KCC4 (show SLC12A7 Proteins)
Treatment of cells expressing mouse K-Cl cotransporter Kcc1 with several chemical cross-linkers shifted Kcc1 polypeptide to higher MW forms. The N-terminal & C-terminal cytoplasmic tails of Kcc1 were not essential for Kcc1 crosslinking.
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
solute carrier family 12 (potassium/chloride transporters), member 4
, little ears
, solute carrier family 12 member 2
, solute carrier family 12 member 4
, electroneutral potassium-chloride cotransporter 1
, erythroid K-Cl cotransporter 1
, potassium/chloride cotransporter 1
, furosemide-sensitive K-Cl cotransporter
, solute carrier family 12, member 4
, K-Cl cotransporter 1
, K-Cl cotransporter 4
, K-Cl Co-transporter-1
, K-Cl cotransporter KCC1