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The protein encoded by SLC22A9 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 9 Proteins (4) and many more products for this protein.
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renal expression of Oat5 in rats (and mice) exhibits zonal and sex differences
Highly expressed in kidney. Motive forces behind Oat5 function, which provide insight into its membrane localization, need to be further resolved.
mOATLP1 appears to be a novel candidate for an organic anion transporter (show SLC22A6 Antibodies) isoform identified in the kidney.
Pravastatin is the first identified OAT7 drug substrate. Substantial inter-individual variability in hepatic OAT7 expression, majorly driven by HNF4alpha (show HNF4A Antibodies), may contribute to pravastatin drug disposition and might affect response.
The first genome-wide association study for serum uric acid level in Indians revealed association of SLC2A9 (show SLC2A9 Antibodies), SLC22A11 (show SLC22A11 Antibodies) and ABCG2 (show ABCG2 Antibodies) gene variants at genome wide significance level in Type 2 diabetes patients.
The regulation of hOAT4 activity was mediated by sgk2 (show SGK2 Antibodies) acting through Nedd4-2 (show NEDD4L Antibodies).
SLC22A11 (show SLC22A11 Antibodies) at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS (show SULT2A1 Antibodies) for placental estriol synthesis.
Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11 (show SLC22A11 Antibodies)/SLC22A12 (show SLC22A12 Antibodies) locus that presumably influence the activity of OAT4 and URAT1 (show SLC22A12 Antibodies) and risk of gout.
When investigating the genes separately, SLC22A11 (show SLC22A11 Antibodies) and SLC2A9 (show SLC2A9 Antibodies) showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney.
Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.
The down-regulation of hOAT4 activity by activation of protein kinase C (show PKC Antibodies) and the up-regulation of hOAT4 activity by NHERF-1 (show SLC9A3R1 Antibodies) are mediated through alteration of hOAT4 internalization.
Glycosylation serves as a means to specifically regulate hOAT4 function in vivo.
hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia.
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.
solute carrier family 22 (organic anion transporter), member 9
, solute carrier family 22 (organic cation transporter), member 19
, organic anion transporter 5
, solute carrier family 22 (organic anion transporter), member 19
, solute carrier family 22 (organic anion/cation transporter), member 9
, solute carrier family 22 member 10
, organic anion transporter 4
, organic anion transporter 7
, solute carrier family 22 member 9
, solute carrier family 22, member 25
, solute carrier family 22 (organic anion/cation transporter), member 11
, solute carrier family 22 member 11