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Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping SLC25A27 Antibodies (26) and many more products for this protein.
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This study found that the variability of UCP4 does affect the individual susceptibility to Late-Onset Alzheimer's Disease.
UCP4 mRNA of cartilage tissues was decreased in osteoarthritis patients, which was negatively correlated with synovial fluid (SF) leptin (show LEP Proteins) concentration.
Compares and contrasts all the known human SLC25A (show SLC25A25 Proteins)* genes and includes functional information.
UCP4 is a target effector gene of the NF-kappaB (show NFKB1 Proteins) c-Rel (show NFkBP65 Proteins) prosurvival pathway to mitigate the effects of oxidative stress.
Neuronal UCP4 exhibits transmembrane chloride transport activity.
Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II.
UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor (show PGR Proteins) expression, and positivity for p53 (show TP53 Proteins) and Ki-67 (show MKI67 Proteins) in breast carcinomas.
A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.(
the association found between the ultra-resistant schizophrenia group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia.
has a significant role in NF-kappaB (show NFKB1 Proteins)-mediated prosurvival signaling and cell protection against neurotoxins
UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production.
astrocytes expressing more UCP4 produce more lactate, which is used as an energy source by neurons, and have the ability to enhance neuronal survival
UCP2 (show UCP2 Proteins) is present in cells with highly proliferative potential, which have a glycolytic type of metabolism as a common feature, whereas UCP4 is strongly associated with non-proliferative highly differentiated neuronal cells
Adipocytes overexpressing UcpP4 showed decreased mitochondrial copy number (mtDNA) and lower mRNA expression of key factors in mitochondrial biogenesis, including PGC-1alpha and mtTFA (show TFAM Proteins).
Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.
, mitochondrial uncoupling protein 4
, uncoupling protein 4
, uncoupling protein UCP-4