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Solute Carrier Family 26, Member 6 Proteins (SLC26A6)

SLC26A6 belongs to the solute carrier 26 family, whose members encode anion transporter proteins. Additionally we are shipping SLC26A6 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SLC26A6 SLC26A6 301010  
SLC26A6 65010 Q9BXS9
SLC26A6 171429  
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Top SLC26A6 Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC26A6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 26, Member 6 (SLC26A6) Interaction Partners

Zebrafish Solute Carrier Family 26, Member 6 (SLC26A6) interaction partners

Human Solute Carrier Family 26, Member 6 (SLC26A6) interaction partners

  1. Molecular dynamics simulations of the STAS domains of rat prestin (show SLC26A5 Proteins) and human pendrin (show SLC26A4 Proteins) reveal conformational motions in conserved flexible regions.

  2. Data show that SLC26A6 variants do not alter the risk for the development of chronic pancreatitis.

  3. In the intestinal epithelium, PAT-1 (show APPBP2 Proteins) (SLC26A6) could mediate apical oxalate influx or apical oxalate efflux depending on the magnitude and direction prevailing counterion driver gradients as well as the relative affinities of the transported anions.

  4. orthologous mouse and human SLC26A6 proteins differ in anion selectivity, transport mechanism, and acute regulation, but both mediate electroneutral Cl(-)/HCO(3)(-) exchange

  5. In human kidney SLC26A6 and A7 have a distinct, partially overlapping expression in distal segments of nephrons. The distribution partly differs from that found previously in rodent kidneys.

  6. findings indicate that slc26a6 functions as a coupled 1Cl-/2HCO3- exchanger

  7. Mouse Slc26a6 and human SLC26A6 each mediated electroneutral Cl-/HCO3- and Cl-/OH- exchange. But, whereas Cl-/oxalate exchange by mouse Slc26a6 was electrogenic, that mediated by human SLC26A6 appeared electroneutral.

  8. No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II (show CA2 Proteins), CA IV (show CA4 Proteins), CA XIV (show CA14 Proteins), kNCB1, NHE3 (show SLC9A3 Proteins), NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.

  9. Low extracellular Cl(-) affinity and electroneutrality of oxalate efflux characterizing human SLC26A6 explain the high human susceptibility to nephrolithiasis relative to mice. SLC26A6 sequence variant(s) are candidate risk modifiers for nephrolithiasis.

  10. involvement of IRF-1 (show IRF1 Proteins) in the regulation of SLC26A6 gene expression by IFNgamma in the human intestine

Mouse (Murine) Solute Carrier Family 26, Member 6 (SLC26A6) interaction partners

  1. Slc26a1, Slc26a6 and Slc26a7 (show SLC26A7 Proteins) are novel participants in the extracellular transport of bicarbonate during enamel maturation.

  2. Results suggest that PAT1 (show APPBP2 Proteins) slows down APP (show APP Proteins) trafficking to the cell surface in primary cortical neurons

  3. Both PAT-1 and DRA significantly contribute to intestinal fluid absorption and enterocyte acid/base balance but are activated by different ion gradients.

  4. Cardiac myocytes express different isoforms of Slc26a6, which encode electrogenic Cl(-)/HCO3(-) and Cl(-)/oxalate exchangers.

  5. Slc26a6-null mice exhibited increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1 (show SLC13A2 Proteins).

  6. NMR and CE were used to characterize the urinary metabolome in slc26a6 null mice. Clear metabolic differentiation between the urinary profiles of the slc26a6 null and the wild type mice were observed using both methods.

  7. SLC26A6 mediates 1:2 Cl-/HCO3- exchange, and the exchanger most probably upregulates SLC26A3 (show SLC26A3 Proteins) in its absence, therefore mediating 2:1 exchange.

  8. Data demonstrate functional Pat-1 Cl)/HCO3) exchange activity in the lower villus epithelium of the murine duodenum which, in previous studies, had been obscured by the inclusion of luminal glucose as a metabolic substrate.

  9. This study showed a functionally active CFTR (show CFTR Proteins) is an absolute requirement for Slc26-mediated duodenal bicarbonate secretion, but not for Slc26-mediated fluid absorption.

  10. study concludes Pat-1 Cl(-)/HCO(3)(-) exchange contributes to pH(i) regulation in the duodenal villous epithelium during H(+)-dipeptide absorption, possibly by providing a HCO(3)(-) import pathway

SLC26A6 Protein Profile

Protein Summary

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with SLC26A6

  • solute carrier family 26 (anion exchanger), member 6 (Slc26a6)
  • solute carrier family 26, member 6 (SLC26A6)
  • solute carrier family 26, member 6 (slc26a6)
  • solute carrier family 26, member 6, like (slc26a6l)
  • solute carrier family 26 (anion exchanger), member 6 (SLC26A6)
  • solute carrier family 26, member 6 (Slc26a6)
  • B930010B04Rik protein
  • CFEX protein
  • MGC81960 protein
  • MGC145603 protein
  • Pat1 protein
  • si:dkey-20d21.8 protein
  • slc26a6 protein
  • zgc:175226 protein

Protein level used designations for SLC26A6

solute carrier family 26, member 6 , solute carrier family 26 member 6 , SLC26A6a anion exchanger , slc26a6c , slc26a6b , anion transporter 1 , pendrin L1 , sulfate anion transporter

GENE ID SPECIES
301010 Rattus norvegicus
416012 Gallus gallus
444778 Xenopus laevis
497236 Sus scrofa
514514 Bos taurus
559448 Danio rerio
608998 Canis lupus familiaris
780378 Xenopus (Silurana) tropicalis
100005108 Danio rerio
100173317 Pongo abelii
100613198 Pan troglodytes
65010 Homo sapiens
171429 Mus musculus
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