Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 Proteins (SLC3A1)

SLC3A1 encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Additionally we are shipping SLC3A1 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC3A1 20532  
SLC3A1 6519 Q07837
Rat SLC3A1 SLC3A1 29484 Q64319
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Top SLC3A1 Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$6,052.17
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 25 to 30 Days
$196.35
Details

SLC3A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , , ,
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More Proteins for Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 (SLC3A1) Interaction Partners

Mouse (Murine) Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 (SLC3A1) interaction partners

  1. a membrane protein AGT1/SLC7A13 is the second partner of rBAT.

  2. In 129S2/SvPasCrl mice, the heavy subunit RBAT of the tetrameric transporter of dibasic amino acids was absent in proximal tubules and identified was a single pathogenic mutation in a highly conserved region of the Slc3a1 gene.

  3. This study demonistrated that slc3a1 gene expression in mouse dorsal raphe nucleus

  4. a decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption

  5. Slc3A1-deficient mice develop cystinuria type I

Human Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 (SLC3A1) interaction partners

  1. Here, the authors report that the expression level of the solute carrier (show SERTAD2 Proteins) family 3, member 1 (SLC3A1), the cysteine carrier, tightly correlated with clinical stages and patients' survival. Elevated SLC3A1 expression accelerated the cysteine uptake and the accumulation of reductive glutathione (GSH), leading to reduced reactive oxygen species (ROS (show ROS1 Proteins)).

  2. We found a novel mutation in the acceptor region in exon 1 (SLC3A1 gene) and detected a heterozygosity status for the described patients.

  3. Five SLC3A1 and SLC7A9 (show SLC7A9 Proteins) mutations appear to be responsible for the genetic basis of cystinuria in the Greek-Cypriot patients

  4. Deletion of the rBAT C-terminal disulfide loop (residues 673-685) prevented maturation and prompted degradation of the transporter.

  5. Report no association of SLC3A1 mutations with clinical course of disease in cystinuria patients.

  6. We present a new pathogenic homozygous mutation, c.833T>C in exon 4 of SLC3A1 gene, in a girl with cystinuria, whose single symptom was an increasingly hyper-echogenic colon in the prenatal sonography as of 30 weeks of gestation.

  7. RBAT gene products, as the primary cause of cystinuria, may function as activators of the amino acid transport system in renal brush border membrane.

  8. We present six family members with a complex phenotypic profile of cystinuria based on mutations in SLC3A1 (type A) or SLC7A9 (show SLC7A9 Proteins) (type B).

  9. Deletion of SLC3A1 is associated with Hypotonia-cystinuria syndrome.

  10. Two novel deletions encompassing the SLC3A1 and PREPL (show PREPL Proteins) genes have been identified in unrelated hypotonia-cystinuria syndrome patients.

SLC3A1 Protein Profile

Protein Summary

This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with SLC3A1

  • solute carrier family 3, member 1 (Slc3a1)
  • solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (SLC3A1)
  • solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (slc3a1)
  • solute carrier family 3 (amino acid transporter heavy chain), member 1 (slc3a1)
  • solute carrier family 3 (amino acid transporter heavy chain), member 1 (SLC3A1)
  • ATR1 protein
  • CSNU1 protein
  • D2H protein
  • MGC131051 protein
  • NBAT protein
  • NTAA protein
  • RBAT protein
  • SLC3A1 protein

Protein level used designations for SLC3A1

amino acid transporter SLC3A1 , neutral and basic amino acid transport protein rBAT , solute carrier family 3, member 1 , solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 , membrane glycoprotein , neutral and basic amino acid transport protein rBAT-like , B(0,+)-type amino acid transport protein , SLC3A1 variant B , SLC3A1 variant C , SLC3A1 variant D , SLC3A1 variant E , SLC3A1 variant F , SLC3A1 variant G , amino acid transporter 1 , solute carrier family 3 (cystine, dibasic and neutral amino acid transporters), member 1 , D2 , NAA-TR , b(0,+)-type amino acid transport protein

GENE ID SPECIES
20532 Mus musculus
403700 Canis lupus familiaris
428569 Gallus gallus
459194 Pan troglodytes
535601 Bos taurus
714035 Macaca mulatta
734933 Xenopus laevis
780365 Xenopus (Silurana) tropicalis
100009060 Oryctolagus cuniculus
100032244 Monodelphis domestica
100144588 Sus scrofa
100401185 Callithrix jacchus
100442610 Pongo abelii
100467387 Ailuropoda melanoleuca
100545774 Meleagris gallopavo
6519 Homo sapiens
29484 Rattus norvegicus
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