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Solute Carrier Family 39 (Zinc Transporter), Member 4 Proteins (SLC39A4)

SLC39A4 encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. Additionally we are shipping Solute Carrier Family 39 (Zinc Transporter), Member 4 Antibodies (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC39A4 55630 Q6P5W5
SLC39A4 72027 Q78IQ7
Rat SLC39A4 SLC39A4 300051 A0JPN2
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Top Solute Carrier Family 39 (Zinc Transporter), Member 4 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SLC39A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4) Interaction Partners

Human Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4) interaction partners

  1. Data sho (show SPRN Proteins) that silencing of zinc transporter ZIP4 resulted in increased bone tissue mineral density, and restoration of bone strength.

  2. The results described a previously uncharacterized role of ZIP4 in apoptosis resistance and elucidated a novel pathway through which ZIP4 regulates pancreatic cancer growth.

  3. In glioma tumors, high ZIP4 expression was significantly associated with higher grade.

  4. Developed is a structural model of ZIP4 by combining protein prediction methods with in situ experiments. Insight into the permeation pathway of ZIP4 is provided.

  5. SLC39A4 mutations have roles in zinc deficiency

  6. Both acrodermatitis mutations cause absence of the ZIP4 transporter cell surface expression and nearly absent zinc uptake.

  7. ZIP4 activates the zinc-dependent transcription factor CREB (show CREB1 Proteins) and requires this transcription factor to increase miR (show MLXIP Proteins)-373 expression through the regulation of its promoter.

  8. High ZIP4 expression is associated with glioma.

  9. resulkts indicate ZIP4 is the only zinc transporter that is significantly up-regulated in pancreatic cancer and might be the major zinc transporter that plays an important role in pancreatic cancer growth

  10. The results suggest that ZIP4 may be a tumor suppressor gene and down-regulation of ZIP4 may be a critical early event in the development of prostate carcinoma

Mouse (Murine) Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4) interaction partners

  1. While Zip4 was not found to be essential for proper glucose homeostasis and insulin (show INS Proteins) secretion in vivo in mice, this study found that Zip4 mediates increases in cytoplasmic and granular zinc pools and stimulates glucose dependent insulin (show INS Proteins) secretion in-vitro

  2. These studies strongly suggest that wasting and lethality in acrodermatitis enteropathica patients reflects the loss-of-function of the intestine zinc transporter ZIP4, which leads to abnormal Paneth cell gene expression

  3. Cell migration assays revealed that RNAi knockdown of Zip4 in Hepa cells depressed in vitro migration whereas forced over-expression in Hepa cells and MCF-7 cells enhanced in vitro migration

  4. ZIP4 physically interacts with tPA (show PLAT Proteins), correlating with an increased intracellular zinc influx and lysosomal sequestration after excitotoxin stimulation. Changes in prosurvival signals support the idea that this sequestration results in neuroprotection.

  5. results provide compelling evidence that ZIP4 is a zinc transporter that plays an important role in zinc homeostasis, a process that is defective in acrodermatitis enteropathica in humans

  6. ZIP4 and ZIP5 (show SLC39A5 Proteins) have roles in the adaptive response to dietary zinc in mice

  7. that heterozygous mutations in the acrodermatitis gene Zip4 (Slc39a4) may be associated with a wider range of developmental defects than was previously appreciated, particularly when dietary zinc is limiting.

  8. ZIP4 is induced by zinc deficiency in cultured mouse Hepa cells and is rapidly degraded in response to added zinc

  9. The processing of ZIP4 may represent a significant regulatory mechanism controlling its function.

  10. KLF4 (show KLF4 Proteins) is induced during zinc restriction and is a transcription factor involved in adaptive regulation of the zinc transporter ZIP4

Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4) Protein Profile

Protein Summary

This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The transmembrane protein is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica, a rare inherited defect in the absorption of dietary zinc. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC39A4

  • solute carrier family 39 (zinc transporter), member 4 (SLC39A4)
  • solute carrier family 39 (zinc transporter), member 4 (slc39a4)
  • solute carrier family 39 (zinc transporter), member 4 (Slc39a4)
  • 1600025H15Rik protein
  • AEZ protein
  • AU041686 protein
  • AWMS2 protein
  • ZIP4 protein

Protein level used designations for SLC39A4

solute carrier family 39 (zinc transporter), member 4 , ZIP4 , zinc transporter ZIP4-like , zinc transporter ZIP4 , zrt- and Irt-like protein 4 , ZIP-4 , solute carrier family 39 member 4 , solute carrier family 39, member 4 , activated in W/Wv mouse stomach 2 , mAWMS2

GENE ID SPECIES
464462 Pan troglodytes
482096 Canis lupus familiaris
562762 Danio rerio
100400831 Callithrix jacchus
100597084 Nomascus leucogenys
55630 Homo sapiens
510951 Bos taurus
72027 Mus musculus
300051 Rattus norvegicus
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